Organometallic Compounds
Medchemexpress LLC Aminooxy-PEG3-C2-NH-Boc | 2062663-65-2 | C13H28N2O6 | 100 MG
Aminooxy-PEG3-C2-NH-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG- and alkyl/ether-based linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Bromoacetamido-PEG3-C2-Boc | 1807537-33-2 | C15H28BrNO6 | 500 MG
Bromoacetamido-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs are molecules that contain two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates selective degradation of target proteins
Medchemexpress LLC Methotrexate hydrate | 133073-73-1 | 99.6% | 1 G
Methotrexate hydrate is a substance that affects cell growth and division. It is commonly used to fight certain diseases, especially cancer and autoimmune diseases. It works by inhibiting the process by which cells synthesize DNA. This product is for research use only and not sold to patients.
- Affects cell growth and division
- Commonly used to fight certain diseases, especially cancer and autoimmune diseases
- Works by inhibiting the process by which cells synthesize DNA
- Biochemical reagent for life science related research
- Can be used as a biological material or organic compound
Frontier Specialty Chemicals 5G POTASSIUM METHOXYMETHYLTRIF
Potassium methoxymethyltrifluoroborate; CAS: 910251-11-5; 5g
Medchemexpress LLC Azide-PEG3-tos | 178685-33-1 | 329.37 g/mol | C13H19N3O5S | 250 MG
Azide-PEG3-Tos is a heterobifunctional PEG linker containing an azide functional group for click chemistry. It acts as a non-cleavable, three-unit PEG linker used in the synthesis of PROTACs and antibody-drug conjugates, and participates in copper-catalyzed and strain-promoted azide-alkyne cycloaddition reactions.
- Heterobifunctional PEG linker with azide group.
- Molecular weight 329.37 g/mol.
- Chemical formula C13H19N3O5S.
- CAS number 178685-33-1.
- Available in 250 MG packaging; other sizes available.
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Applications: PROTAC synthesis, ADC construction, click chemistry.
Medchemexpress LLC Lipoamide-PEG3-Mal | 1314378-19-2 | 99.6% | C25H41N3O7S2 | 1 MG
Lipoamide-PEG3-Mal is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules feature two distinct ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other binding to a specific target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- One ligand targets an E3 ubiquitin ligase
- Other ligand targets the target protein
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Bis-aminooxy-PEG3 | 98627-70-4 | 98.0% | C8H20N2O5 | 50 MG
Bis-aminooxy-PEG3 (CAS: 98627-70-4) is a chemical compound with the molecular formula C8H20N2O5 and a molecular weight of 224.25. It is typically a colorless to light yellow liquid. This product is intended for research use only.
- Purity of 98.0% by NMR
- Store at 4°C, protected from light
- When in solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light
- Appearance is a colorless to light yellow liquid
- Chemical structure consistent with 1H NMR and MS analysis
![Medchemexpress LLC 5,8,11-Trioxa-2-azatridecanoic acid, 13-hydroxy-, (1α,8α,9ẞ)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester | 2126749-77-5 | 99.6% | 369.45 g/mol | C19H31NO6 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202514.png-250.jpg)
Medchemexpress LLC 5,8,11-Trioxa-2-azatridecanoic acid, 13-hydroxy-, (1α,8α,9ẞ)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester | 2126749-77-5 | 99.6% | 369.45 g/mol | C19H31NO6 | 50 MG
BCN-PEG3-OH is a BCN-functionalized PEG linker intended for bioconjugation and antibody-drug conjugate (ADC) synthesis. The reagent contains a bicyclo[6.1.0]nonyne (BCN) group that reacts with azides via strain-promoted alkyne-azide cycloaddition (SPAAC), enabling copper-free click chemistry in aqueous conditions.
- Non-cleavable four-unit PEG linker suitable for ADC construction.
- Enables strain-promoted alkyne-azide cycloaddition with azide-functionalized molecules.
- High reported purity for reliable conjugation performance.
- Available in multiple pack sizes, including small research quantities.
Medchemexpress LLC N-(Boc-PEG3)-N-bis(PEG3-acid) | 2055042-61-8 | 97.0% | C31H60N2O15 | 25 MG
N-(Boc-PEG3)-N-bis(PEG3-acid) is a PEG-based PROTAC linker. It is designed for use in the synthesis of PROTACs. This product is for research use only.
- PEG-based PROTAC linker
- For use in the synthesis of PROTACs
- For research use only
Medchemexpress LLC Azido-PEG3-SSPy | 98.6% | 344.45 g/mol | C13H20N4O3S2 | 25 MG
Azido-PEG3-SSPy is a cleavable three-unit polyethylene glycol (PEG) linker containing an azide functional group, designed for bioconjugation and antibody-drug conjugate (ADC) synthesis. It enables click chemistry (CuAAC) and strain-promoted azide-alkyne cycloadditions (SPAAC) for attachment to alkyne- or DBCO/BCN-containing molecules.
- Cleavable disulfide-containing PEG linker suitable for ADC construction.
- Azide-functionalized for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN.
- Supplied as a colorless to light yellow liquid with high purity.
- Suitable for bioconjugation and linker development in drug conjugates.
Medchemexpress LLC Azido-PEG5-alcohol | 86770-68-5 | >97.0% | 263.29 g·mol⁻¹ | C10H21N3O5 | 5 G
Azido-PEG5-alcohol is an azide-terminated polyethylene glycol linker containing five ethylene glycol units and a terminal primary alcohol, used as a water-soluble reagent for bioconjugation and linker synthesis. It is commonly applied in click chemistry and in the construction of antibody-drug conjugates and PROTACs.
- Azide functionality enables CuAAC and SPAAC click reactions.
- Water-soluble PEG5 spacer improves solubility and flexibility.
- Terminal primary alcohol provides a synthetic handle for derivatization.
- Suitable for ADC linker synthesis and PROTAC construction.
- Supplied as a solid with reported purity >97.0%.
Medchemexpress LLC Boc-NH-PEG3-propargyl | 1333880-60-6 | 97.0% | C14H25NO5 | 100 MG
Boc-NH-PEG3-propargyl is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Used in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules
Medchemexpress LLC Azido-PEG5-triethoxysilane | 3025193-22-7 | MFCD31693730 | 95.0% | C22H46N4O9Si | 25 MG
Azido-PEG5-triethoxysilane is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, which allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Used in the synthesis of PROTACs.
- Functions as a click chemistry reagent.
- Contains an Azide group for copper-catalyzed azide-alkyne cycloaddition reactions.
- Can undergo strain-promoted alkyne-azide cycloaddition reactions.
- PROTACs enable selective degradation of target proteins via the intracellular ubiquitin-proteasome system.