Organometallic Compounds
Medchemexpress LLC NH-bis(PEG3-azide) | 1258939-39-7 | 98.0% | C16H33N7O6 | 250 MG
NH-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Azide group, and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Peg-based protac linker
- Used in the synthesis of protacs
- Functions as a click chemistry reagent
- Contains an azide group
- Capable of copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups
- Capable of strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Medchemexpress LLC Pomalidomide-PEG3-C2-NH2 TFA | 2414913-97-4 | 99.0% | 2 G
Pomalidomide-PEG3-C2-NH2 TFA is a synthetic E3 ligase ligand-linker conjugate, featuring a Pomalidomide-based cereblon ligand and a 3-unit PEG linker. This compound is designed for the synthesis of PROTACs and is intended for research use only.
- Synthetic E3 ligase ligand-linker conjugate
- Features a Pomalidomide-based cereblon ligand and 3-unit PEG linker
- Utilized for the synthesis of PROTACs
- High purity: 99.0%
- Molecular weight: 562.49
- Chemical formula: C23H29F3N4O9
- Appears as a light yellow to yellow solid-liquid mixture
- Soluble in DMSO, ethanol, and water
- Offers multiple dissolution protocols for in vivo studies
Medchemexpress LLC Ethanol, 2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]- | 60221-37-6 | 98.7% | 25 G
THP-PEG3-OH is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs feature two ligands connected by a linker, one for an E3 ubiquitin ligase and another for a target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade specific target proteins.
- High purity of 98.7%
- Molecular weight of 234.29
- Chemical formula is C11H22O5
- Appears as a liquid
- Colorless to light yellow
- Utilizes the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Tamra-PEG3-azide | 1228100-59-1 | 96.4% | 630.69 g/mol | C33H38N6O7 | 10MG
TAMRA-PEG3-Azide is a red-fluorescent TAMRA dye derivative bearing a three-unit polyethylene glycol (PEG3) spacer and a terminal azide functional group. It is intended for bioorthogonal conjugation to biomolecules via copper-catalyzed or strain-promoted azide-alkyne cycloaddition, offering a fluorescent label with improved solubility and spacer length.
- Red-fluorescent dye with excitation/emission maxima 553/575 nm
- Terminal azide enables CuAAC and SPAAC click chemistry
- PEG3 spacer improves solubility and reduces steric interference
- High purity (≈96.4%) in solid form
- Soluble in methanol at about 12.5 mg/mL (19.82 mM); ultrasonic may be required
- Storage: powder -20°C; in solvent -80°C for 6 months or -20°C for 1 month
![Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | 1306615-51-9 | MFCD28505530 | 95.0% | 234.25 g/mol | C8H18N4O4 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202088.png-250.jpg)
Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | 1306615-51-9 | MFCD28505530 | 95.0% | 234.25 g/mol | C8H18N4O4 | 10 MG
Aminooxy-PEG3-azide is a PEG-based bifunctional linker containing an aminooxy (oxyamine) group and an azide group. It is used as a non-cleavable three-unit PEG spacer for antibody-drug conjugate (ADC) and PROTAC synthesis, and as an azide reagent for click chemistry reactions such as CuAAC and SPAAC.
- Bifunctional aminooxy and azide groups for oxime ligation and click chemistry.
- Non-cleavable three-unit PEG spacer suitable for ADC and PROTAC linker installation.
- Purity 95.0% and molecular weight 234.25 g/mol.
- Appearance colorless to light yellow liquid for easy handling.
- Storage: pure form -20°C (stable 3 years); in solvent -80°C (6 months) or -20°C (1 month).
- Available in small pack sizes, including 10 mg for small-scale synthesis.
Medchemexpress LLC PEG3-C4-OBn | 2381196-79-6 | 99.3% | 100 MG
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. It can be used in the synthesis of the PROTAC SGK3 degrader-1, which is a potent SKG3 degrader.
- Polyethylene glycol (PEG)-based PROTAC linker
- Used in the synthesis of PROTAC SGK3 degrader-1
- High solubility in DMSO (≥ 100 mg/mL)
- Long-term stability in pure form at -20°C (3 years) and 4°C (2 years)
- Extended stability in solvent at -80°C (6 months) and -20°C (1 month)
Medchemexpress LLC Bis-PEG5-PFP ester | 1334177-78-4 | 100 MG
Bis-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Contains two different ligands connected by a linker.
- One ligand targets an E3 ubiquitin ligase; the other targets the protein.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
Medchemexpress LLC Tos-PEG5-Boc | 581065-94-3 | ≥97.0% | 250 MG
Tos-PEG5-Boc is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase and a ligand for the target protein. It has a molecular weight of 476.58 and a chemical formula of C22H36O9S. Its appearance is a viscous liquid, colorless to light yellow.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
- Viscous liquid, colorless to light yellow appearance
- For research use only
Medchemexpress LLC (S,R,S)-AHPC-C2-PEG3-BCN | 2876198-36-4 | 99.2% | 810.01 g·mol⁻¹ | C42H59N5O9S | 10 MG
(S,R,S)-AHPC-C2-PEG3-BCN (Compound 16b) is a VHL E3 ligase ligand-linker conjugate used as a building block in the synthesis of PROTACs and other conjugates. It features a PEG3 spacer and a bicyclononyne (BCN) functional group to facilitate bioorthogonal conjugation and assembly of bifunctional molecules for targeted protein degradation research.
- VHL E3 ligase ligand for targeted protein degradation applications.
- PEG3 linker provides a flexible spacer for molecular conjugation.
- BCN functional group enables strain-promoted bioorthogonal click conjugation.
- Reported high purity suitable for synthetic chemistry use.
- Intended as a small-molecule building block for PROTAC assembly and conjugation workflows.
Medchemexpress LLC Azido-PEG5-acid | 1425973-16-5 | >98.0% | 335.35 | C13H25N3O7 | 10 G
Azido-PEG5-acid is an azide-terminated five-unit polyethylene glycol (PEG5) acid linker used for bioconjugation and linker synthesis. It functions as a click-chemistry reagent capable of undergoing azide-alkyne cycloaddition reactions and is commonly used in PROTAC and antibody-drug conjugate assembly.
- Azide functional group enables copper-catalyzed and strain-promoted click reactions.
- Five-unit PEG spacer provides solubility and flexibility for conjugation.
- High purity supports synthetic and bioconjugation applications.
- Available in multiple pack sizes for scalable workflows.
- Stable under recommended storage conditions to preserve reactivity.
eMolecules Ambeed / tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate / 100mg / 506388578 / A154148 / / 252881-74-6 / MFCD06201017 / 277.361 / C13H27NO5
Ambeed / tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate / 100mg / 506388578 / A154148 / / 252881-74-6 / MFCD06201017 / 277.361 / C13H27NO5
Medchemexpress LLC Mal-PEG3-NH2 TFA | 2830214-77-0 | 99.1% | 386.32 g/mol | C14H21F3N2O7 | 25 MG
Mal-PEG3-NH2 TFA is a linear heterobifunctional polyethylene glycol crosslinker supplied as the trifluoroacetic acid (TFA) salt. It features a maleimide group for selective thiol conjugation and a primary amine for subsequent modification, making it useful as a non-degradable PROTAC linker and general bioconjugation reagent for research applications.
- Maleimide and primary amine functional groups for orthogonal conjugation.
- Supplied as TFA salt for enhanced stability and handling.
- High purity suitable for research-scale bioconjugation (≈99.1%).
- Available in small mg packaging for precision experiments.
- Non-degradable (non-cleavable) linker for stable conjugates.
Medchemexpress LLC 2-(2-(2-((6-chlorohexyl)oxy)ethoxy)ethoxy)ethan-1-ol | 1355955-95-1 | MFCD32705069 | 268.78 g·mol^-1 | C12H25ClO4 | 100 MG
HO-PEG3-(CH2)6-Cl (2-(2-(2-((6-chlorohexyl)oxy)ethoxy)ethoxy)ethan-1-ol) is a hydroxy-terminated PEG3 linker bearing a 6-chlorohexyl reactive handle. It is used as a flexible, hydrophilic spacer in the synthesis of PROTACs and Halo-tag targeting conjugates, enabling attachment between target-binding ligands and recruitment motifs.
- Hydroxy-terminated PEG3 spacer with a 6-chlorohexyl functional group.
- Molecular formula C12H25ClO4; molecular weight 268.78 g·mol^-1.
- Designed for use in PROTAC and Halo-tag conjugate synthesis.
- Available in multiple pack sizes including 100 MG.
- Analytical documentation available on request (CoA, H NMR, SDS).
Medchemexpress LLC (S,R,S)-AHPC-PEG3-NH2 hydrochloride | 2097971-11-2 | MFCD31656714 | 99.0% | 656.23 g/mol | C30H46ClN5O7S | 500 MG
(S,R,S)-AHPC-PEG3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that combines an (S,R,S)-AHPC-based VHL ligand with a three-unit polyethylene glycol (PEG3) linker terminating in a primary amine. It is supplied as the hydrochloride salt and is used as a building block in PROTAC synthesis and other chemical biology applications.
- E3 ligase VHL ligand-linker conjugate for targeted protein degradation research.
- PEG3 linker with terminal primary amine suitable for conjugation.
- Hydrochloride salt form for improved stability and handling.
- High purity (≈99%) suitable for synthetic applications.
- Available in multiple preweighed sizes including 500 MG.
eMolecules Chem-Impex Tetraisopropyl orthotitanate 5kg 686070058 41289 0 000 546-68-9 MFCD00008871 284 219 C12H28O4Ti
Chem-Impex Tetraisopropyl orthotitanate 5kg 686070058 41289 0 000 546-68-9 MFCD00008871 284 219 C12H28O4Ti