Organometallic Compounds
Medchemexpress LLC Azide-PEG5-Boc | 1415800-41-7 | C17H33N3O7 | 500 MG
Azide-PEG5-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. PROTACs are designed to selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Utilizes the intracellular ubiquitin-proteasome system to degrade target proteins
- For research use only
Medchemexpress LLC Ethanamine, 2-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethoxy]- | 1261350-60-0 | 95.0% | 267.79 | 25 MG
NH2-PEG3-C6-Cl is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets a specific protein. This mechanism leverages the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
Medchemexpress LLC Azido-PEG5-alcohol | 86770-68-5 | >97.0% | 263.29 g·mol⁻¹ | C10H21N3O5 | 5 G
Azido-PEG5-alcohol is an azide-terminated polyethylene glycol linker containing five ethylene glycol units and a terminal primary alcohol, used as a water-soluble reagent for bioconjugation and linker synthesis. It is commonly applied in click chemistry and in the construction of antibody-drug conjugates and PROTACs.
- Azide functionality enables CuAAC and SPAAC click reactions.
- Water-soluble PEG5 spacer improves solubility and flexibility.
- Terminal primary alcohol provides a synthetic handle for derivatization.
- Suitable for ADC linker synthesis and PROTAC construction.
- Supplied as a solid with reported purity >97.0%.
Medchemexpress LLC Pomalidomide-PEG3-C2-NH2 TFA | 2414913-97-4 | 99.0% | 50 MG
Pomalidomide-PEG3-C2-NH2 TFA is a synthetic E3 ligase ligand-linker conjugate. It is composed of a Pomalidomide-based cereblon ligand and a 3-unit PEG linker. This compound is suitable for the synthesis of PROTACs. It has a molecular weight of 562.49, a chemical formula of C23H29F3N4O9, and typically appears as a light yellow to yellow solid-liquid mixture. This product is for research use only and not intended for human use.
- Synthetic E3 ligase ligand-linker conjugate
- Pomalidomide-based cereblon ligand
- 3-unit PEG linker
- Suitable for PROTACs synthesis
- Target: Cereblon