Organometallic Compounds
Medchemexpress LLC N3-PEG3-CH2CH2-Boc | 252881-73-5 | ≥98.0% | 303.35 g·mol⁻¹ | C13H25N3O5 | 250 MG
N3-PEG3-CH2CH2-Boc is a Boc-protected, azide-terminated PEG3 linker used in conjugation chemistry for synthesizing PROTACs and antibody-drug conjugates. It contains a three-unit polyethylene glycol spacer with an azide functional group that enables click chemistry reactions such as copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC).
- Boc-protected azide terminus for selective conjugation.
- Three-unit PEG spacer provides flexibility and improves solubility.
- Compatible with CuAAC and SPAAC click reaction methodologies.
- High purity suitable for synthetic applications (≥98.0%).
- Available in multiple pack sizes, including 250 MG.
Medchemexpress LLC Azido-PEG5-acid | 1425973-16-5 | >98.0% | 335.35 g/mol | C13H25N3O7 | 250 MG
Azido-PEG5-acid is an azide-functional, five-unit polyethylene glycol (PEG5) linker used for conjugation chemistry, including PROTAC and antibody-drug conjugate synthesis, and for click-chemistry applications. Supplied for research use only.
- Peg5 linker with azide functionality for click chemistry.
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Compatible with strain-promoted azide-alkyne cycloaddition (SPAAC) using DBCO or BCN reagents.
- Purity ≥98.0%.
- Appearance: colorless to light yellow liquid.
- Storage: pure form stable at -20°C for 3 years and 4°C for 2 years.
Medchemexpress LLC BM-PEG3 | 86099-06-1 | 98.0% | 100 MG
BM-PEG3 is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) are compounds that utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They function by connecting two different ligands, one for an E3 ubiquitin ligase and another for the target protein, enabling targeted degradation.
- PEG-based PROTAC linker
- For research use only
- Purity: 98.0%
- Molecular weight: 352.34
- Molecular formula: C16H20N2O7
- Appearance: White to light yellow solid
- Storage as powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Solubility in DMSO: 100 mg/mL (in vitro)
- Solubility in 10% DMSO, 90% corn oil: ≥ 2.5 mg/mL (in vivo)
Medchemexpress LLC Ph-PEG3 1g
Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC Bis-PEG5-acid 1g | 439114-13-3 | 338.35 g/mol | C14H26O9 | 1 G
Bis-PEG5-acid is a polyethylene glycol (PEG) linker bearing two terminal carboxylic acid groups, used as a hydrophilic spacer in PROTAC construction and bioconjugation chemistry. It facilitates coupling reactions and improves aqueous solubility for assembled molecules.
- Two terminal carboxylic acid groups enable standard amide coupling reactions.
- PEG5 spacer provides hydrophilicity and conformational flexibility.
- Molecular weight 338.35 g/mol and formula C14H26O9 for precise stoichiometry.
- Suitable for PROTAC synthesis and general linker applications in medicinal chemistry.
- Offered in research quantities including 1 g for small-scale synthesis.
Medchemexpress LLC Azido-peg3-dykddddk tfa | 1242.20 | 5 MG
Azido-PEG3-DYKDDDDK (azide-PEG3-FLAG) TFA is a multifunctional fusion tag used for the purification of recombinant proteins. This click chemistry reagent contains an azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Multifunctional fusion tag for the purification of recombinant proteins
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing alkyne groups
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
Medchemexpress LLC Aminooxy-PEG3-acid | 1807540-79-9 | 95.0% | 237.25 | 50 MG
Aminooxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC N-(Boc-PEG3)-N-bis(PEG2-alcohol) | 2055042-60-7 | C25H52N2O11 | 250 MG
N-(Boc-PEG3)-N-bis(PEG2-alcohol) is a PEG-based PROTAC linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). PROTACs are designed to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables targeted protein degradation via the ubiquitin-proteasome system
- Facilitates connection between an E3 ubiquitin ligase ligand and a target protein ligand
Medchemexpress LLC Bromoacetamido-PEG3-C2-Boc | 1807537-33-2 | C15H28BrNO6 | 1 G
Bromoacetamido-PEG3-C2-Boc is a PEG-based PROTAC linker that is utilized in the synthesis of PROTACs. PROTACs themselves are small molecules composed of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a protein of interest. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Application: used in the synthesis of PROTACs.
- Mechanism: facilitates the degradation of target proteins via the ubiquitin-proteasome system when incorporated into PROTACs.
- Research use: for research purposes only; not intended for sale to patients.
- Form: liquid (density: 1.252 g/cm3), colorless to light yellow.
Medchemexpress LLC Ms-PEG5-t-butyl ester | 870487-48-2 | C16H32O9S | 25 MG
Ms-PEG5-t-butyl ester is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are molecules that contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for a target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PROTAC linker
- PEG-based structure
- Target PROTACs
- Pathway PROTAC
- Used in the synthesis of PROTACs
Medchemexpress LLC N-(Azido-PEG3)-N-bis(PEG4-acid) | 2112731-54-9 | 98.0% | C30H58N4O15 | 50 MG
N-(Azido-PEG3)-N-bis(PEG4-acid) is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This compound acts as a click chemistry reagent, featuring an Azide group. It can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions when combined with Alkyne groups. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne groups
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Medchemexpress LLC Tos-PEG3 | 77544-68-4 | 97.0% | 304.36 | 1 G
Tos-PEG3 is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. It can also be used for the synthesis of 3'-aminooxy oligonucleotides solid supports.
- Can be used in the synthesis of PROTACs
- Can be utilized for the synthesis of 3'-aminooxy oligonucleotides solid supports
Medchemexpress LLC Dbco-nhco-peg3-fmoc | 00-00-0 | 96.9% | C42H43N3O7 | 10MG
DBCO-NHCO-PEG3-Fmoc is a DBCO-functionalized PEG3 linker with an Fmoc-protected amine designed for use as a click-chemistry reagent in PROTAC synthesis and bioconjugation. It participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing partners, offering modular attachment and improved handling for linker assembly.
- Click-reactive DBCO group enables strain-promoted alkyne-azide cycloaddition (SPAAC).
- Peg3 spacer improves solubility and reduces steric hindrance.
- Fmoc-protected amine allows compatibility with solid-phase and solution-phase synthesis workflows.
- High purity suitable for research applications.
- Stable as powder at -20°C for extended storage and recommended cold storage in solution.
Medchemexpress LLC N-(acid-PEG3)-N-bis(PEG3-azide) | 2182602-17-9 | 98.07% | C25H49N7O11 | 250 MG
N-(acid-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules that contain Alkyne groups, or in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Composed of two different ligands connected by a linker
- One ligand targets an E3 ubiquitin ligase
- The other targets the protein of interest
- Operates by harnessing the intracellular ubiquitin-proteasome system
- Facilitates the selective degradation of target proteins
- Intended for research use only
Medchemexpress LLC 5,8,11-Trioxa-2,14-diazahexadecanoic acid, 16-bromo-15-oxo-, 1,1-dimethylethyl ester | 1421933-39-2 | ≥98.0% | C15H29BrN2O6 | 500 MG
Bromoacetamido-PEG3-NH-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to selectively degrade target proteins by utilizing the ubiquitin-proteasome system, connecting ligands for an E3 ubiquitin ligase and the target protein via a linker.
- Suitable for PROTAC synthesis
- Utilizes PEG-based linker technology
- Facilitates targeted protein degradation