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Organometallic compounds contain direct bonds between carbon atoms and metal atoms/ions and play roles as homogeneous catalysts and stoichiometric reagents in reactions; available in various chemical compositions, quantities, purities, and reagent grades.
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Br-PEG3-MS is a brominated, PEG-based PROTAC linker (methanesulfonate) designed for use in chemical synthesis of PROTACs and other bifunctional molecules. It provides a short PEG3 spacer with a reactive leaving group for conjugation chemistry, enabling efficient formation of linkages between ligands under standard organic conditions. For research use only.
PEG3 spacer with a terminal bromide and methanesulfonate leaving group.
Suitable for linker synthesis and nucleophilic substitution reactions.
High purity (95.0% by NMR) for reliable synthetic performance.
Low molecular weight facilitates handling in small-scale reactions.
Available in multiple small pack sizes to support medicinal chemistry workflows.
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OSI-930 (CAS 728033-96-3) is a small molecule inhibitor targeting multiple receptor tyrosine kinases including Flt1 (IC 8 nM) KDR/VEGFR2 (IC 9 nM) CSF-1R (IC 15 nM) Lck c-Raf and Kit (IC 80 nM) In cellular studies OSI-930 inhibits proliferation and induces apoptosis in HMC-1 cells whose survival is dependent on Kit signaling while exhibiting minimal effects on COLO-205 cells under standard conditions Additionally OSI-930 inactivates cytochrome P450 3A4 in a time- and concentration-dependent manner and alters its spectral properties These characteristics make OSI-930 a valuable tool compound for investigating receptor tyrosine kinase signaling pathways and related cellular processes in cancer research
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