Steroids and derivatives
Medchemexpress LLC Alpha-estradiol | 57-91-0 | MFCD00064144 | 99.9% | 272.39 | C18H24O2 | 10 MG
Alpha-estradiol (analytical standard) is a reference material intended for analytical testing and method development. It is a weak estrogen and a 5α-reductase inhibitor supplied as a high-purity solid suitable for calibration, qualitative analyses, and quantitative assays in research and laboratory workflows.
- Analytical reference standard for research and method validation.
- High stated purity for accurate calibration (99.93%).
- Supplied as a solid for convenient handling and storage.
- Available in small pack sizes appropriate for analytical use (10 mg).
- Applicable to studies of estrogenic activity and 5α-reductase inhibition.
Cambridge Isotope Laboratories Estradiol (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
Estradiol (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
Medchemexpress LLC β-estradiol-6-CMO-PEG3-biotin | 2938875-38-6 | 97.8% | 759.95 g·mol⁻¹ | C38H57N5O9S | 1 MG
β-Estradiol-6-CMO-PEG3-biotin is a biotinylated estradiol derivative used as a cleavable three-unit polyethylene glycol (PEG3) linker for antibody-drug conjugate (ADC) synthesis. It provides a hydrophilic spacer and a biotin handle to facilitate conjugation, affinity capture, and detection in downstream assays.
- Cleavable three-unit PEG linker providing hydrophilicity and spacing.
- Biotin tag enables affinity capture and detection.
- High purity (97.82%) suitable for research applications.
- Soluble in DMSO at ≥ 50 mg/mL; use freshly opened DMSO.
- Stable as a powder at -20°C for up to 3 years; limited stability in solvent as specified by manufacturer.
Cayman Chemical 2-bromo 17-EstradIol 25mg
A synthetic steroid and inhibitor of estrogen 2-hydroxylase; inhibits estrogen 2-hydroxylase in rat liver microsomes at 50 and 100 µM; prevents estrogen-induced inhibition of apomorphine-induced climbing behavior in mice at 5 mg/kg
Medchemexpress LLC Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-sulfamate | 172377-52-5 | MFCD00947822 | 351.46 | 25 MG
Estradiol 3-sulfamate, also identified as BLE 00084, E2MATE, or ES-J 995, is characterized as a potent, long-acting, and orally active inhibitor of steroid sulfatase.
- Potent steroid sulfatase inhibitor
- Long-acting steroid sulfatase inhibitor
- Orally active steroid sulfatase inhibitor
- Inhibits estrone sulfatase with an IC50 of 251 nM
- Inhibits estrone sulfatase with a Ki of 133 nM
Sigma Aldrich Fine Chemicals Biosciences beta-Estradiol 17-beta-D-g10MG
BETA7 beta-Estradiol 17-beta-D-g10MG
Medchemexpress LLC Estradiol 3-methyl ether | 1035-77-4 | 99.9% | 286.41 | 10 MG
Estradiol 3-methyl ether is a synthetic estrogen that can disrupt microtubule networks in V79 cells with an EC50 of 9 μM and inhibit cell proliferation. Additionally, it decreases serum cholesterol levels and increases body weight loss, showing feminizing activity in an HFD murine model.
- Synthetic estrogen
- Disrupts microtubule networks
- Inhibits cell proliferation
- Decreases serum cholesterol levels
- Increases body weight loss
- Useful for biochemical assays
- Potential for research into microtubule modulation and cell proliferation
- Applicable in studies related to cholesterol regulation and weight management in relevant models
Medchemexpress LLC Estradiol dipropionate | 113-38-2 | 99.5% | 50 MG
Estradiol dipropionate is a combined estrogen-progesterone that acts as an estrogen and progesterone agonist. It is for research use only and not sold to patients.
- Acts as an estrogen and progesterone agonist.
- Suitable for in vivo studies.
- Used in research for metabolic or endocrine disease.
Sigma Aldrich Fine Chemicals Biosciences beta-Estradiol 6-O-carboxy5MG
BETA beta-Estradiol 6-O-carboxy5MG
Medchemexpress LLC Estradiol-d3 | 79037-37-9 | 98.6% | 5 MG
Estradiol-d3 is a deuterium-labeled form of Estradiol, a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. It upregulates IL-6 expression via the estrogen receptor β (ERβ) pathway and is intended for research use only. This compound serves as a tracer and internal standard for quantitative analysis, leveraging the potential of deuteration to influence pharmacokinetic and metabolic profiles.
- Used as a tracer
- Used as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Deuteration influences drug pharmacokinetic and metabolic profiles
- Appears as a white to off-white solid
- Molecular weight: 275.40
- Chemical formula: C18H21D3O2
- Powder storage: -20°C for 3 years or 4°C for 2 years
- Solvent storage: -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO (50 mg/mL) and ethanol (20 mg/mL)
Medchemexpress LLC Estradiol 3-glucuronide sodium | 14982-12-8 | 1 MG
Estradiol 3-glucuronide sodium is an estrogen metabolite, a glucuronide conjugate formed in tissues like the liver from Estradiol. It is a potent substrate of Mrp2, achieving hepatobiliary transport in hepatocytes via basolateral uptake through OATP1B1, OATP1B3, and OATP2B1, and apical efflux via MRP2 and BCRP. For research use only.
- Substrate for OATP1B1, OATP1B3, and OATP2B1 in HEK293T cells.
- Uptake inhibited by OATP substrates and inhibitors.
- Inhibits OATP1B3- and OATP2B1-mediated estrone-3-sulfate uptake.
- Inhibits OATP1B1-, OATP1B3-, OATP2B1-mediated Rosuvastatin uptake.
- Substrate of rat Mrp2 in Sf9 cell membrane vesicles.
- Competitively inhibits rat Mrp2-mediated Estradiol 17-glucuronide transport.
- Used to produce high-affinity antiserum for radioimmunoassay in urine samples.
Sigma Aldrich Fine Chemicals Biosciences Estradiol hemihydrate European Pharmacopoeia (EP) Reference Standard | 35380-71-3 | MFCD23102821 |
Estradiol hemihydrate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 281.39 | 35380-71-3 | MFCD23102821 |
Cayman Chemical 17-EstradIol-d3 10mg
An internal standard for the quantification of 17β-estradiol by GC- or LC-MS
Selleck Chemical LLC Ethinyl Estradiol S1625-1g
Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills
Selleck Chemical LLC Alpha-Estradiol
Alpha-Estradiol ( -Estradiol 17 alpha-Estradiol Alfatradiol Epiestradiol Epiestrol Alora 17 -E2) a natural non-feminizing stereoisomer a hormonally almost inactive isomer of physiological 17 beta-estradiol (17 -E2) is a weak inhibitor of estrogen