Acetylides
Medchemexpress LLC Bis-propargyl-PEG4 | 159428-42-9 | 95.6% | 5 G
Bis-propargyl-PEG4 is a PEG-based bifunctional linker featuring terminal propargyl (alkyne) groups, designed for conjugation chemistry and PROTAC construction. It provides a short, flexible spacer for joining two ligands via click chemistry.
- Bifunctional PEG4 linker with terminal alkyne groups.
- Enables copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Useful for PROTAC synthesis and dimer formation.
- Low molecular weight (270.32 g/mol) for compact linker design.
- Stable under recommended storage conditions when kept dry and refrigerated.
Medchemexpress LLC Propargyl-PEG8-acid | 2055014-94-1 | 98.0% | 436.49 g/mol | C20H36O10 | 100 MG
Propargyl-PEG8-acid is a propargyl-functionalized polyethylene glycol (PEG8) carboxylic acid linker designed for bioconjugation and linker chemistry. It provides a PEG8 spacer with a terminal alkyne for click chemistry and a carboxylic acid for coupling reactions; it is supplied as a high-purity solid with defined stability and storage requirements.
- Propargyl terminal alkyne suitable for copper-catalyzed click chemistry.
- Peg8 spacer improves solubility and flexibility in conjugates.
- Carboxylic acid functionality enables amide coupling and derivatization.
- High purity (approximately 98.0%) for reliable synthetic performance.
- Molecular weight 436.49 g/mol, formula C20H36O10.
- Available in small-scale packs (100 mg) and larger sizes for scale-up.
- Store at -20°C under inert atmosphere; in solvent, follow recommended cold storage times.
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | MFCD28334507 | ≥98.0% | 407.50 g/mol | C19H37NO8 | 1 G
Propargyl-PEG8-NH2 is a polyethylene glycol (PEG8) alkyne linker bearing a terminal primary amine. It is used as a non-cleavable linker in conjugation chemistry, including ADC and PROTAC synthesis, and as a click-chemistry building block for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Alkyne functional group for CuAAC click reactions.
- Terminal primary amine for conjugation and linker formation.
- High purity (≥98.0%).
- Molecular weight 407.50 g/mol.
- Chemical formula C19H37NO8.
- Available in multiple package sizes, including 1 G.
Medchemexpress LLC Propargyl-PEG4-CH2CO2-NHS | 2144777-76-2 | 343.33 | 100 MG
Propargyl-PEG4-CH2CO2-NHS (compound P-7) is a PEG derivative containing a propargyl group and an NHS group. It is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also categorized as a click chemistry reagent, possessing an alkyne group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.
- PEG derivative with propargyl and NHS groups.
- Acts as an ADC linker for synthesizing antibody-drug conjugates.
- Functions as a click chemistry reagent.
- Contains an alkyne group, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.
Medchemexpress LLC 3-Butynyl p-toluenesulfonate | 23418-85-1 | MFCD00041687 | >97.0% | 224.28 g/mol | C11H12O3S | 5 G
Propargyl-tos (3-butynyl p-toluenesulfonate) is a propargyl-containing tosylate ester used as a cleavable linker and an alkynyl reagent for click chemistry, bioconjugation, and linker synthesis in medicinal chemistry. It is supplied as a purified solid for synthetic chemistry applications.
- Cleavable ADC linker and click chemistry reagent.
- Used in bioconjugation and linker synthesis.
- High purity (>97.0%) available for synthetic applications.
- Molecular weight 224.28 g/mol and formula C11H12O3S.
- Supplied in small pack sizes suitable for laboratory synthesis.
Medchemexpress LLC 2-((Benzo[d]thiazol-2-ylmethyl)thio)-4,5,6,7-tetrahydro-8H-cyclopenta[d]triazolo[1,5-a]pyrimidin-8 | 3112403-98-9 | 99.9% | 355.44 | 25 MG
WS-917 is a potent and orally active ABCB1 modulator that enhances ABCB1 ATPase activity. It significantly enhances the antitumor effect of paclitaxel when combined with an anti-PD-1 antibody, and also promotes CD8+ T-cell activation. This product is for research use only and has not been fully validated for medical applications.
- Potent and orally active ABCB1 modulator
- Enhances ABCB1 ATPase activity
- Significantly enhances antitumor effect of paclitaxel combined with anti-PD-1 antibody
- Promotes CD8+ T-cell activation
eMolecules Ambeed / N-Boc-Propargylamine / 1g / 552613515 / A171481 / / 92136-39-5 / MFCD07367245 / 155.197 / C8H13NO2
Ambeed / N-Boc-Propargylamine / 1g / 552613515 / A171481 / / 92136-39-5 / MFCD07367245 / 155.197 / C8H13NO2
eMolecules Ambeed / 4-Bromobutyryl chloride / 1g / 570996278 / A708194 / / 927-58-2 / MFCD00000753 / 185.450 / C4H6BrClO
Ambeed / 4-Bromobutyryl chloride / 1g / 570996278 / A708194 / / 927-58-2 / MFCD00000753 / 185.450 / C4H6BrClO
Medchemexpress LLC Propargyl-PEG2-bromi 250mg
Propargyl-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1] Propargyl-PEG2-bromide is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Accela Chembio Inc MF: C10H8O2 | MW: 160.17 | >97% | Flash Point: 92? | BP: 239.4? at 760 mmHg.
MF: C10H8O2 | MW: 160.17 | >97% | Flash Point: 92? | BP: 239.4? at 760 mmHg.
Medchemexpress LLC Propargyl-PEG6-alcohol | 944560-99-0 | 97.0% | 1 G
Propargyl-PEG6-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Used in the synthesis of proteolysis targeting chimeras (PROTACs)
- Contains an alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Propargyl-peg2-oh | 7218-43-1 | 99.66% | 5 G
Propargyl-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of Thalidomide-O-PEG2-propargyl. This compound is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups. It has a molecular weight of 144.17 and a formula of C7H12O3. It appears as a colorless to light yellow liquid with a density of 1.06 g/cm3 and a purity of 99.66%.
- Peg-based protac linker
- Utilized in the synthesis of thalidomide-o-peg2-propargyl
- Click chemistry reagent
- Contains an alkyne group for cuaac reactions
- Intended for research use only
- Soluble in ethanol (≥ 100 mg/ml)
Medchemexpress LLC Propargyl-PEG9-amine | 2093153-98-9 | 97.0% | 250 MG
Propargyl-PEG9-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent that contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Click chemistry reagent
- Alkyne group for reactions
- Used in PROTAC synthesis
- Applicable in cancer research
- Supports cancer targeted therapy
- PROTAC linker
Medchemexpress LLC Propargyl-peg1-acid | 55683-37-9 | 97.0% | 250 MG
Propargyl-PEG1-acid is a PEG-based PROTAC linker. It is utilized in the synthesis of BTK-CRBN PROTACs and functions as a click chemistry reagent. This product incorporates an Alkyne group which can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Utilized in the synthesis of BTK-CRBN PROTACs
- Functions as a click chemistry reagent
- Incorporates an Alkyne group
- Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Propargyl-PEG4-Br | 1308299-09-3 | 5 G
Propargyl-PEG4-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a non-cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).
- Functions as a PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Acts as a non-cleavable ADC linker
- Utilized in the synthesis of antibody-drug conjugates (ADCs)
- Serves as a click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups