Acetylides
![Medchemexpress LLC Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 1,1-dimethylethyl ester | 1807503-80-5 | 95.0% | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 1,1-dimethylethyl ester | 1807503-80-5 | 95.0% | 250 MG
This compound is a polyethylene glycol (PEG)-based PROTAC linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It acts as a click chemistry reagent due to its alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.
- Application: Can be employed in the synthesis of PROTACs.
- Characteristics: It contains an alkyne group and can participate in copper-catalyzed azide-alkyne cycloaddition.
Medchemexpress LLC Propargyl-PEG4-CH2-methyl ester | 1872433-63-0 | 250 MG
Propargyl-PEG4-CH2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Peg-based protac linker
- Click chemistry reagent
- Contains an alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
Medchemexpress LLC Propargyl-PEG7-NHS ester | 2093152-77-1 | 489.51 g/mol | C22H35NO11 | 250 MG
Propargyl-PEG7-NHS ester is an amine-reactive PEG-based linker used for bioconjugation, antibody-drug conjugate (ADC) and PROTAC synthesis, and click-chemistry applications. The reagent contains a terminal propargyl (alkyne) group and an N-hydroxysuccinimide (NHS) ester for coupling to primary amines.
- Amine-reactive NHS ester for efficient coupling to primary amines.
- Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- PEG7 spacer improves solubility and provides flexibility between conjugated moieties.
- Available in small laboratory pack sizes for research use.
eMolecules 4-Fluoro-2-(trifluoromethoxy)-DL-phenylalanine | 1435806-18-0 | MFCD19687192 | 1g
Apollo Scientific | 4-Fluoro-2-(trifluoromethoxy)-DL-phenylalanine | 1g | 562460231 | PC302877 | | 1435806-18-0 | MFCD19687192 | 267.180 | C10H9F4NO3
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STA PHARMACEUTICAL US LLC 2'-propargyl G(iBu) amidite | 1 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 30 mL Glass (20-400)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 47.3 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
Medchemexpress LLC E -Pent-2-enal 10g
(E)-Pent-2-enal has a pungent fruity odor This compound is commonly used in the flavor and fragrance industry because of its strong aroma often described as fresh and green Furthermore (E)-Pent-2-enal can be used as an intermediate in the synthesis of various organic compounds including pharmaceuticals and agrochemicals Its unique chemical properties make it an important ingredient in many commercial products including perfumes air fresheners and cleaners
Medchemexpress LLC 4-pentynoic acid, 2,5-dioxo-1-pyrrolidinyl ester | 132178-37-1 | 99.8% | 195.17 g/mol | C9H9NO4 | 250 MG
Propargyl-C1-NHS ester is an N-hydroxysuccinimide (NHS) ester bearing a propargyl (alkyne) handle used as a non-cleavable linker and click-chemistry reagent for antibody-drug conjugation and general bioconjugation. It couples to primary amines via NHS-ester chemistry and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing partners.
- Alkyne-functional NHS ester for click chemistry
- Suitable for antibody-drug conjugation and bioconjugation workflows
- Reacts with primary amines via NHS ester coupling
- Compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC)
- High purity and available in multiple pack sizes, including 250 mg
- Soluble in DMSO; store sealed, away from moisture and light
Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 1 G
Propargyl-PEG4-acid is a PEG-based PROTAC linker primarily used in the synthesis of BTK-IAP PROTACs. It also functions as a click chemistry reagent, containing an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups. These PROTACs act as stoichiometric degraders, leading to the degradation of BTK protein by recruiting IAP E3 ligases.
- PEG-based PROTAC linker
- Used in the synthesis of BTK-IAP PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group for CuAAc reactions
- Enables degradation of BTK protein
Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 500 MG
Propargyl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of BTK-IAP PROTACs Ibrutinib-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells.
- PEG-based PROTAC linker
- Can be used in the synthesis of BTK-IAP PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
Medchemexpress LLC Propargyl-PEG7-acid | 2093154-00-6 | ≥98.0% | 1 G
Propargyl-PEG7-acid is a PEG-based PROTAC linker and a cleavable ADC linker, making it valuable for synthesizing PROTACs and antibody-drug conjugates. It also functions as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.
- Used in the synthesis of PROTACs
- Cleavable ADC linker
- Utilized in the synthesis of antibody-drug conjugates (ADCs)
- Functions as a click chemistry reagent
- Contains an Alkyne group for copper-catalyzed azide-alkyne cycloaddition
Medchemexpress LLC Propargyl-PEG8-OH | 1351556-81-4 | 1 G
Propargyl-PEG8-OH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Propargyl-PEG6-acid | 1951438-84-8 | 5 G
Propargyl-PEG6-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). This compound is a click chemistry reagent containing an Alkyne group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing Azide groups.
- Peg-based protac linker for protac synthesis.
- Cleavable adc linker for antibody-drug conjugate synthesis.
- Click chemistry reagent containing an alkyne group.
- Enables copper-catalyzed azide-alkyne cycloaddition (cuaac) with azide groups.
Medchemexpress LLC Propargyl-PEG8-Boc | 2055014-96-3 | 1 G
Propargyl-PEG8-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups. This compound is instrumental in developing PROTACs, which are designed to selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Contains an Alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Interacts with Azide groups
- Facilitates selective degradation of target proteins
Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 10 G
Propargyl-PEG4-acid is a PEG-based PROTAC linker. It can be used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and analogue PROTAC 3, which causes BTK degradation. Propargyl-PEG4-acid is also a click chemistry reagent, featuring an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in synthesis of BTK-IAP PROTACs
- PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells
- Click chemistry reagent with Alkyne group
- Can undergo CuAAc with Azide groups
Medchemexpress LLC Propargyl-PEG9-amine | 2093153-98-9 | 97.0% | 50 MG
Propargyl-PEG9-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with molecules containing Azide groups