Halohydrins
eMolecules 92920-33-7 | 3,6-dichloro-4-fluoropyridazine | Pharmablock | MFCD21648467 | 166.960 | C4HCl2FN2 | 97.000 | Fc1cc(Cl)nnc1Cl | 500mg | 551218809
3,6-dichloro-4-fluoropyridazine | Pharmablock | 92920-33-7 | MFCD21648467 | 166.960 | C4HCl2FN2 | 97.000 | Fc1cc(Cl)nnc1Cl | 500mg | 551218809
Apexbio Technology LLC YH239-EE 1364488-67-4 50mg
YH239-EE (CAS 1364488-67-4) is a small molecule antagonist of the p53-MDM2 interaction By disrupting the binding between p53 a tumor suppressor transcription factor and its negative regulator MDM2 YH239-EE reactivates p53 signaling pathways In acute myeloid leukemia (AML) cell models such as OCI-AML-3 MOLM-13 and NB4 YH239-EE inhibits cell proliferation and induces cell cycle arrest accompanied by significant accumulation of sub-G1 populations It promotes apoptosis with rates observed up to 13 1-fold over control in NB4 cells and activates caspase 3/7 in MOLM-13 cells Enantiomers display distinct biological activity with EC50 values of 7 5 M and 25 2 M YH239-EE serves as a valuable tool for studying p53-MDM2 modulation in cancer research
Medchemexpress LLC HY-103349 5mg Medchemexpress, PETCM CAS:10129-56-3 Purity:>98%
Medchemexpress, HY-103349 5mg PETCM CAS:10129-56-3 PETCM is an activator of caspase-3. PETCM can induces cell apoptosis and stimulate apoptosome formation in HeLa cell cytosols. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![Medchemexpress LLC Ethyl 3-[(tert-butylcarbamoyl)(N-[(4-chlorophenyl)methyl]formamido)methyl]-6-chloro-1H-indole-2-carboxylate | 1364488-67-4 | 98.3% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232395.png-250.jpg)
Medchemexpress LLC Ethyl 3-[(tert-butylcarbamoyl)(N-[(4-chlorophenyl)methyl]formamido)methyl]-6-chloro-1H-indole-2-carboxylate | 1364488-67-4 | 98.3% | 50 MG
YH239-EE is the ethyl ester of a small-molecule MDM2/p53 antagonist used in vitro to disrupt the p53-MDM2 interaction, inducing cell-cycle arrest and apoptosis in p53 wild-type acute myeloid leukemia (AML) cell lines. Supplied as a high-purity solid and available in multiple sizes and solution formats for cellular and biochemical assays.
- Antagonizes the p53-MDM2 interaction in vitro.
- Induces cell-cycle arrest and apoptosis in p53 wild-type AML cells.
- High purity (98.3%) solid, white to off-white, suitable for research assays.
- Available in multiple quantities and as a 10 mM solution in DMSO for cell-based studies.
- Molecular weight 504.41 g/mol; formula C25H27Cl2N3O4.
Medchemexpress LLC 2,3-dichloro-1-propanol-d5 | 1189730-34-4 | 98.0% | 134.02 g/mol | C3HD5Cl2O | 5 MG
2,3-Dichloro-1-propanol-d5 is a deuterium-labeled analogue of 2,3-dichloro-1-propanol supplied for research use. It functions as a tracer and internal standard for quantitative analyses and is characterized with a certificate of analysis and safety data sheet.
- Deuterium-labeled tracer for analytical studies.
- Suitable as an internal standard for NMR, GC-MS, and LC-MS.
- Purity 98.0%.
- Available in small quantities, including 5 mg.
- Store pure material at -20 °C; in solvent store at -80 °C or -20 °C.
eMolecules 627-18-9 | 3-Bromo-1-propanol | Chem-Impex | MFCD00002942 | 138.992 | C3H7BrO | 95.000 | OCCCBr | 25g | 112760345
3-Bromo-1-propanol | Chem-Impex | 627-18-9 | MFCD00002942 | 138.992 | C3H7BrO | 95.000 | OCCCBr | 25g | 112760345
Medchemexpress LLC 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine | 145783-15-9 | 99.99% | 238.14 | 500 G
4,6-Dichloro-2-(propylthio)pyrimidin-5-amine is a drug intermediate for the synthesis of various active compounds. It is for research use only and not for sale to patients.
- Used in the synthesis of various active compounds.
- Suitable for research applications.
- Not intended for human use.
eMolecules 540-51-2 | 2-Bromoethanol | Oakwood Chemical | MFCD00002827 | 124.965 | C2H5BrO | 97.000 | OCCBr | 5g | 537711492
2-Bromoethanol | Oakwood Chemical | 540-51-2 | MFCD00002827 | 124.965 | C2H5BrO | 97.000 | OCCBr | 5g | 537711492
Medchemexpress LLC Bronopol | 52-51-7 | 98.0% | 100 G
Bronopol is an antibacterial agent effective against Gram-negative bacteria. It functions by oxidizing protein thiols, inhibiting enzymatic activity, and acting as a formaldehyde releaser. In vitro, it activates THP-1 cells, increases CD86 expression, induces IL-8 secretion, and promotes early expression of HMOX1 and HSPA6 genes. In vivo, it can induce chemical peritonitis and transitory pain aggressive behavior in Sprague-Dawley rat models.
- Antibacterial agent with low toxicity to mammals
- Effective against Gram-negative bacteria
- Oxidizes protein thiols and inhibits enzymatic activity
- Acts as a formaldehyde releaser
- Activates THP-1 cells and increases CD86 expression in vitro
- Induces IL-8 secretion and promotes gene expression in vitro
- Can induce chemical peritonitis and pain in Sprague-Dawley rat models in vivo