Hydrochlorides
Medchemexpress LLC SKF-96365 hydrochlor 10mM 1mL
SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2 entry (SOCE) inhibitor SKF-96365 hydrochloride significantly inhibits hERG hKCNQ1/hKCNE1 hKir2 1 and hKv4 3 current and significantly prolongs the QTc interval in isolated guinea pig hearts SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells1]2]
Medchemexpress LLC PD 128907 hydrochloride | 112960-16-4 | 99.5% | 285.77 g/mol | C14H20ClNO3 | 5 MG
PD 128907 hydrochloride is the hydrochloride salt of a potent, selective dopamine D3 receptor agonist used as a biochemical reagent for pharmacology and dopaminergic signaling research. Supplied as a solid, white to light yellow powder, it has reported purity of 99.51%, molecular formula C14H20ClNO3, and molecular weight 285.77 g/mol.
- Potent D3 receptor agonist with EC50 of 0.64 nM.
- Approximately 53-fold selectivity for D3 over D2 receptors.
- High reported purity suitable for biochemical assays.
- Solid form simplifies storage and handling.
- Stable under recommended sealed storage conditions for short-term and long-term use.
Medchemexpress LLC AQ-13 dihydrochloride | 169815-40-1 | 98.1% | 364.74 | C16H24Cl3N3 | 50 MG
AQ-13 dihydrochloride is an aminoquinoline antimalarial research compound reported to be active against drug-resistant strains of Plasmodium falciparum. It is supplied as a solid for laboratory use and should be handled according to safety protocols; not for human or clinical use.
- Aminoquinoline antimalarial agent active against drug-resistant Plasmodium falciparum.
- Solid form suitable for laboratory handling.
- Reported purity approximately 98.1%.
- Molecular weight 364.74 g/mol.
- CAS number 169815-40-1 for unambiguous identification.
- Store sealed, away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Piperoxan hydrochloride | 135-87-5 | MFCD00079224 | ≥98% | 269.77 g/mol | C14H20ClNO2 | 1 ML
Piperoxan hydrochloride is an α2 adrenoceptor antagonist and first-generation antihistamine supplied as a 10 mM solution in DMSO (1 mL) for research use. It is identified by CAS 135-87-5 and has a molecular weight of 269.77 g/mol. The ready-to-use format is intended for in vitro receptor pharmacology and small-scale assay applications.
- Ready-to-use 10 mM solution in DMSO.
- Suitable for adrenergic receptor and antihistamine research.
- Supplied at 1 mL volume for small-scale assays.
- Molecular weight 269.77 g/mol; CAS 135-87-5.
- Reported high purity (≥98%) in supplier documentation.
Medchemexpress LLC PXS-4787 hydrochloride | 2409964-40-3 | C10H13ClFNO2S | 10 MM * 1 ML
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor that abolishes lysyl oxidase activity. It inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4). This compound also reduces the deposition and crosslinking of collagen I secreted by human fibroblasts. It is for research use only and not sold to patients.
- Specific and effective pan-LOX inhibitor
- Abolishes lysyl oxidase activity
- Inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4)
- Reduces deposition and crosslinking of collagen I secreted by human fibroblasts
- For research use only
Medchemexpress LLC Ly-272015 hydrochloride | 172895-15-7 | 99.5% | 372.89 | C21H25ClN2O2 | 25 MG
LY-272015 hydrochloride is the hydrochloride salt of LY-272015, an orally active and selective 5-HT2B receptor antagonist supplied as a high-purity solid for laboratory research. It is used to probe serotonergic signaling and downstream ERK2 phosphorylation in preclinical studies.
- Orally active, selective 5-HT2B receptor antagonist.
- Useful for research into serotonergic signaling and ERK2 phosphorylation.
- High purity (about 99.5%) for reliable experimental results.
- Off-white to light yellow solid, suitable for analytical handling.
- Stable when stored sealed at 4°C; in solvent: -80°C for 6 months, -20°C for 1 month.
- Available in small research quantities, including 25 MG.
Medchemexpress LLC PXS-6302 hydrochloride | 2584947-79-3 | C10H11ClF3NO2S | 50 MG
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor known for its good skin penetrability, ability to reduce collagen deposition, and significant improvement of scar appearance. This compound is intended for research use only.
- Irreversible lysyl oxidase inhibitor
- Exhibits IC50s for Bovine LOX (3.7 μM), rh LOXL1 (3.4 μM), rh LOXL2 (0.4 μM), rh LOXL3 (1.5 μM), and rh LOXL4 (0.3 μM)
- Reduces collagen deposition and cross-linking in murine models of injury and fibrosis with topical application
- Significantly improves scar appearance in porcine injury models without reducing tissue strength
- Inhibits LOX and reduces crosslinking in porcine models of excisional and burn injury
TARGETMOL CHEMICALS INC Cefotiam Hexetil Hydrochlor
Also available in 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Cefotiam Hexetil Hydrochloride is a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Purity 100%
Apexbio Technology LLC RS 127445 HCl 199864-87-4 10mM (in 1mL DMSO)
RS 127445 HCl (CAS 199864-87-4) is a small-molecule antagonist targeting the serotonin 5-HT2B receptor a member of the G-protein coupled receptor family It is designed to selectively block 5-HT2B receptor activity thereby modulating intracellular signaling pathways such as calcium elevation and inositol phosphate production RS 127445 HCl exerts its biological activity primarily through selective antagonism of the 5-HT2B receptor In isolated tissue preparations such as rat stomach fundus and jugular vein RS 127445 HCl inhibits serotonin-induced contraction Based on these pharmacological properties RS 127445 HCl holds research potential in studies of 5-HT2B receptor function and related physiological processes
Medchemexpress LLC DRP1i27 dihydrochloride | C20H28Cl2N6O | 1 ML
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Directly binds to and inhibits the GTPase activity of human Drp1.
- Increases cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner.
- Has a binding affinity of 286 μM in the SPR assay and a KD value of 190 μM via the MST assay.
Medchemexpress LLC KB-0742 dihydrochloride | 2416874-75-2 | 98.8% | 360.33 | 50 MG
KB-0742 dihydrochloride is a potent, selective, and orally active inhibitor of CDK9/cyclin T1, demonstrating an IC50 of 6 nM. It exhibits over 50-fold selectivity against other CDK kinases and shows significant anti-tumor activity. This compound has been shown to reduce downstream phosphorylation of RNA Pol II at Ser2, Ser7, and Ser5, and to diminish global androgen receptor protein levels in prostate cancer cells. It also displays antiproliferative effects in various cancer cell lines, such as prostate cancer and leukemia.
- Potent and selective CDK9 inhibitor.
- Orally active with significant anti-tumor efficacy.
- Exhibits high selectivity for CDK9/cyclin T1 over other CDK kinases.
- Induces significant reduction of RNA Pol II phosphorylation.
- Demonstrates antiproliferative activity in cancer cell lines.
Apexbio Technology LLC VU 0361737 1161205-04-4 5mg
VU 0361737 (CAS 1161205-04-4) is a selective brain-penetrant positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4) It demonstrates high selectivity for mGluR4 over other mGluR subtypes with EC50 values of 240 nM for human and 110 nM for rat mGluR4 and shows minimal to no activity at mGluR1 mGluR2 mGluR3 mGluR6 and mGluR7 while exhibiting weak activity at mGluR5 and mGluR8 VU 0361737 crosses the blood-brain barrier and achieves significant brain exposure (brain plasma ratio of 4 1) with a short half-life (T1/2 20 min) following administration in rats This compound is utilized in studies exploring the modulation of basal ganglia neurotransmission and the pathophysiology of Parkinson s disease