Hydrochlorides
Medchemexpress LLC T-3775440 hydrochloride | 1422535-52-1 | 99.1% | 346.85 g/mol | C18H23ClN4O | 50 MG
T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase 1 (LSD1) with low-nanomolar potency. It is provided as a high-purity research reagent for biochemical and cellular studies of epigenetic regulation.
- Irreversible LSD1 inhibition with an IC50 of ~2.1 nM.
- High chemical purity suitable for research use.
- Available in small-scale quantities for screening and mechanistic studies.
- Useful for biochemical assays and cellular models of epigenetic regulation.
- Provided as a hydrochloride salt to improve stability and solubility.
Medchemexpress LLC 2-(benzofuran-2-yl)-2-imidazoline hydrochloride | 89196-95-2 | MFCD00672666 | >=98.0% | 222.67 g/mol | C11H11ClN2O | 25 MG
RX 801077 hydrochloride (2-BFI) is a research compound that acts as a selective imidazoline I2 receptor (I2R) agonist. It is used in preclinical studies for its reported anti-inflammatory and neuroprotective effects and is suitable for investigations into traumatic brain injury and related neurobiology.
- Selective imidazoline I2 receptor agonist with a reported Ki of ≈70.1 nM.
- Demonstrates anti-inflammatory and neuroprotective activity in preclinical models.
- Supplied as a hydrochloride salt for improved stability and handling.
- High purity suitable for analytical and exploratory studies (≥98%).
- Well-characterized chemical data: C11H11ClN2O, molecular weight 222.67 g/mol, CAS 89196-95-2.
- Available in small-scale quantities appropriate for laboratory research.
Medchemexpress LLC H-hyp-ome hydrochloride | 40216-83-9 | 98.0% | 181.62 g/mol | C6H12ClNO3 | 500 G
H-Hyp-OMe hydrochloride is the hydrochloride salt of the methyl ester of trans-4-hydroxy-L-proline, used as a non-cleavable ADC linker, a PROTAC linker building block, and a synthetic intermediate in medicinal chemistry.
- Hydrochloride salt form suitable for conjugation chemistry.
- Molecular weight 181.62 g/mol; formula C6H12ClNO3.
- Purity 98.0%.
- Available in bulk 500 g pack.
- SDS and COA PDFs available for handling and quality data.
Sigma Aldrich Fine Chemicals Biosciences Procaine hydrochloride >=97% | 51-05-8 | MFCD00013000 | 50G
Procaine hydrochloride >=97% | Purity: >=97% | Mol Wt: 272.77 | 51-05-8 | MFCD00013000 | 50G
Medchemexpress LLC Roxindole hydrochloride | 108050-82-4 | 99.5% | 382.93 g·mol⁻1 | C23H27ClN2O | 50 MG
Roxindole hydrochloride is a research-grade small molecule used as a pharmacological tool to study serotonin and dopamine receptor activity. It functions as a 5-HT1A agonist and dopaminergic modulator and is provided as a hydrochloride salt for use in in vitro and biochemical assays.
- Used to probe 5-HT1A and dopamine receptor pharmacology
- High purity suitable for research assays (HPLC)
- Molecular weight 382.93 g·mol⁻1
- Chemical formula C23H27ClN2O; CAS 108050-82-4
- Available in small solid quantities for laboratory experiments
- Store solid at -20°C and protect from light
eMolecules Broadpharm / 2-Iminothiolane HCl salt / 500mg / 686681063 / BP-27870 / 95.000 / 4781-83-3 / MFCD00216010 / 101.170 / C4H7NS
Broadpharm / 2-Iminothiolane HCl salt / 500mg / 686681063 / BP-27870 / 95.000 / 4781-83-3 / MFCD00216010 / 101.170 / C4H7NS
Medchemexpress LLC PXS-4787 hydrochloride | 2409964-40-3 | C10H13ClFNO2S | 100 MG
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor that abolishes lysyl oxidase activity.
- Inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4).
- Reduces the deposition and crosslinking of collagen I secreted by human fibroblasts.
- Purity of 99.71%.
- Appears as a white to off-white solid.
- Molecular weight of 265.73.
Medchemexpress LLC VU 0364439 | 1246086-78-1 | C18H13Cl2N3O3S | 100 MG
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. While it exhibits less than ideal PK properties for in vivo use, it demonstrates better stability in HLM (63% remaining) compared to RLM (2% remaining).
- mGlu4 positive allosteric modulator
- Exhibits an EC50 of 19.8 nM
- Shows improved stability in HLM (63% remaining) compared to RLM (2% remaining)
- Soluble in DMSO (50 mg/mL)
- Targets mGluR in GPCR/G Protein and neuronal signaling pathways
Medchemexpress LLC RS-127445 | 199864-87-4 | C17H16FN3 | 1 ML
RS-127445 is a selective, high affinity, and orally bioavailable 5-HT2B receptor antagonist. It demonstrates a pKi of 9.5 and exhibits over 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites.
- Selective 5-HT2B receptor antagonist
- High affinity (pKi of 9.5)
- Orally bioavailable
- Over 1000-fold selectivity compared to other receptors
- Potently blocks 5-HT evoked increases in intracellular calcium concentrations
Chemscene ChemScene | 4-Tert-Butylpiperidine hydrochloride | 250MG | CS-0139146 | 0.97 | 69682-13-9| MFCD05865119 | 177.71
ChemScene | 4-Tert-Butylpiperidine hydrochloride | 250MG | CS-0139146 | 0.97 | 69682-13-9| MFCD05865119 | 177.71
Apexbio Technology LLC Terbinafine HCl 78628-80-5 10mM (in 1mL DMSO)
Terbinafine hydrochloride (CAS 78628-80-5) is a small-molecule inhibitor targeting squalene epoxidase It is designed to selectively inhibit this key enzyme within the fungal sterol biosynthesis pathway thereby disrupting cell membrane integrity Terbinafine hydrochloride exerts its biological activity primarily through non-competitive inhibition of squalene epoxidase In experimental studies Terbinafine hydrochloride demonstrates potent antifungal activity with reported IC50 values against fungal squalene epoxidase in the nanomolar range Based on these pharmacological properties Terbinafine hydrochloride holds research potential in antifungal drug mechanism studies fungal sterol metabolism and therapeutic strategies against fungal pathogens in experimental models
Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.9% | 1088.21 | 25 MG
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively, and induces apoptosis.
- Antagonist of inhibitor of apoptosis proteins (IAPs)
- Binds to BIR3 domains of cIAP1, cIAP2, and XIAP
- Induces apoptosis
- Inhibits cell viability in H1975 NSCLC cells in cooperation with IFNγ or viral double-stranded RNA (dsRNA)
- Downregulates cIAP-1, activates RIPK1, and triggers activation of extrinsic and intrinsic apoptosis pathways in H1975 NSCLC cells
- Involves in apoptosis in HCC827 NSCLC cells due to induction of cell death and active caspase-3/8 activities by AZD5582 and IFNγ co-treatment
- Causes degradation of cIAP1 and caspase 3 cleavage in tumor cells in MDA-MB-231 xenograft-bearing mice
Sigma Aldrich Fine Chemicals Biosciences 3-Pyridylacetic acid hydrochloride 98% | 6419-36-9 | MFCD00012819 | 25G
3-Pyridylacetic acid hydrochloride 98% | Purity: 98% | Mol Wt: 173.6 | 6419-36-9 | MFCD00012819 | 25G
Sigma Aldrich Fine Chemicals Biosciences Doxepin hydrochloride ~85% E-isomer basis, >=98% (GC), 15% Z-isomer basis, powder | 1229-29-4 | MFCD00079135 | 1G
Doxepin hydrochloride ~85% E-isomer basis, >=98% (GC), 15% Z-isomer basis, powder | Purity: >=98% (GC); 15% Z-isomer basis; ~85% E-isomer basis | Mol Wt: 315.84 | 1229-29-4 | MFCD00079135 | 1G