Hydrochlorides
Medchemexpress LLC ARC 239 dihydrochloride | 55974-42-0 | 99.2% | 25 MG
ARC 239 dihydrochloride is a selective α2B/2C adrenoceptor antagonist, intended for research use only.
- Selective α2B/2C adrenoceptor antagonist
- Exhibits pKd values of 5.95 at α2A, 7.41 at α2B, and 7.56 at α2C receptors
- Binds to CHO cell membranes expressing human recombinant a2A-, a2B- or a2C-adrenoceptor subtypes
- IC50 & Target includes Alpha-2B adrenergic receptor and 5-HT1A Receptor
Medchemexpress LLC KHK-IN-1 hydrochloride | 1303470-48-5 | 98.0% | 50 MG
KHK-IN-1 hydrochloride is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor. It effectively inhibits the production of F1P in HepG2 cell lysates, demonstrating an IC50 value of 400 nM. This compound holds potential for research related to diabetes and obesity, offering a valuable tool for scientific investigation.
- Demonstrates selectivity as a ketohexokinase inhibitor.
- Is cell membrane permeable, allowing intracellular action.
- Inhibits F1P production in HepG2 cell lysates.
- Possesses potential for studying diabetes and obesity.
- Stable in human and rat liver microsome preparations.
- Does not significantly inhibit cytochrome P450s.
Medchemexpress LLC Rs-127445 hydrochloride | 199864-86-3 | 99.8% | 317.79 g·mol⁻¹ | C17H17ClFN3 | 10 MG
RS-127445 hydrochloride is a selective, high-affinity 5-HT2B receptor antagonist (pKi ≈ 9.5) provided as a research-grade chemical. It shows approximately 1,000-fold selectivity versus other receptors and is supplied as a solid (powder) or as a ready-to-use 10 mM solution in DMSO. Intended for research use only.
Medchemexpress LLC Dopamine hydrochloride | 62-31-7 | 99.8% | 50 MG
Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. It plays important roles in the brain and body by acting through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis. This product is intended for research use only.
- Catecholamine neurotransmitter
- Acts through D2 dopamine receptors
- Induces endocytosis of VEGFR2
- Critical for promoting angiogenesis
- Inhibits VPF/VEGF-induced HUVEC proliferation
- Selectively inhibits vascular permeabilizing and angiogenic activities of VPF/VEGF
Medchemexpress LLC MK2-IN-1 (hydrochloride) | 1314118-94-9 | 98.4% | 1 ML
MK2-IN-1 hydrochloride (compound 1) is a potent and selective MAPKAPK2 (MK2) inhibitor with an IC50 of 0.11 μM for MK2 and an EC50 of 0.35 μM for pHSP27. It impairs the phosphorylation level of serine residues in the Tfcp2l1 protein. This product is for research use only and not sold to patients.
- Potent and selective MAPKAPK2 (MK2) inhibitor
- Gradually increases Tfcp2l1 protein level without a change in transcript level within 2 hours
- Induces more alkaline phosphatase (AP)-positive colonies
- Molecular weight of 509.43
- Chemical formula C27H26Cl2N4O2
- Appears as a light yellow to pink solid
- Highly soluble in H2O and DMSO
Matrix Scientific O-Methylhydroxylamine hydrochloride, 593-56-6, MFCD00012951, 25g
Molecular Formula CH6ClNO, Purity 95+%, Molecular Weight 83.52, Melting Point ca 148 dec.°
Medchemexpress LLC Dopamine (hydrochloride) | 62-31-7 | MFCD00012898 | 99.8% | 100 MG
Dopamine hydrochloride is a catecholamine neurotransmitter produced in the brain's substantia nigra, ventral tegmental area, and hypothalamus. It plays important roles in the brain and body. This compound acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
- Catecholamine neurotransmitter
- Produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain
- Plays several important roles in the brain and body
- Acts through D2 dopamine receptors
- Induces endocytosis of VEGFR2
- Critical for promoting angiogenesis
Medchemexpress LLC Aldoxorubicin hydrochloride | 480998-12-7 | 98.0% | 787.21 g/mol | C37H43ClN4O13 | 10 MG
MC-DOXHZN hydrochloride ((E/Z)-Aldoxorubicin) hydrochloride is an albumin-binding prodrug of doxorubicin that releases the active anthracycline under acidic conditions. It acts as a DNA topoisomerase II inhibitor and is commonly used as a research reagent and as an intermediate for constructing drug-antibody conjugates.
- Albumin-binding prodrug with acid-sensitive release
- Functions as a DNA topoisomerase II inhibitor
- Suitable as an intermediate for drug-antibody conjugates
- Supplied as a solid with high stated purity
- Small pack sizes available for research applications
Sigma Aldrich Fine Chemicals Biosciences Olopatadine hydrochloride United States Pharmacopeia (USP) Reference Standard | 140462-76-6 | MFCD00875716 | 150MG
Olopatadine hydrochloride United States Pharmacopeia (USP) Reference Standard | Mol Wt: 373.87 | 140462-76-6 | MFCD00875716 | 150MG
Medchemexpress LLC PND-1186 hydrochloride | 1356154-94-3 | 99.9% | 537.96 | 25 MG
PND-1186 hydrochloride is a potent, highly-specific, and reversible inhibitor of FAK with an IC50 of 1.5 nM. It selectively promotes tumor cell apoptosis.
- Potent, highly-specific, and reversible inhibitor of FAK
- Selectively promotes tumor cell apoptosis
- Inhibits FAK Tyr-397 phosphorylation
- Elevates total FAK protein levels
- Inhibits 4T1 subcutaneous tumor growth
- Induces apoptosis in BALB/c mice
Medchemexpress LLC Cyclopentanecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[2-(2,3,5,6-tetrafluorophenoxy)acetyl]bu | 2097865-47-7 | 97.2% | 25 MG
Kgp-IN-1 hydrochloride is an arginine-specific gingipain (Rgp) inhibitor, identified as compound 13-R from patent WO2017201322A1. This product is intended for research use only.
- Arginine-specific gingipain (Rgp) inhibitor
- Targets cathepsin
- Pathway: metabolic enzyme/protease
- White to off-white solid
- Store at 4°C, sealed, away from moisture
![Medchemexpress LLC Acetamide, N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- | 893990-34-6 | MFCD05957363 | 99.7% | 342.44 | C16H14N4OS2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000289016.png-250.jpg)
Medchemexpress LLC Acetamide, N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- | 893990-34-6 | MFCD05957363 | 99.7% | 342.44 | C16H14N4OS2 | 10 MG
VU 0240551 is a small-molecule research compound that acts as a potent neuronal K+-Cl- cotransporter 2 (KCC2) inhibitor and is used in in vitro pharmacology and preclinical studies. It shows submicromolar activity at KCC2 and selectivity versus NKCC1.
- Potent KCC2 inhibitor (IC50 ≈ 560 nM).
- Selective versus NKCC1 (IC50 > 50 μM).
- High purity (99.7%).
- Molecular weight 342.44; formula C16H14N4OS2.
- White to off-white solid with high solubility in DMSO (≥ 50 mg/mL).
- Recommended storage: powder -20 °C (long-term) or 4 °C (shorter term); solvent storage at -80 °C.
- Supplied in small pack sizes suitable for research (5 mg-100 mg).