Hydrochlorides
Medchemexpress LLC RS-127445 | 199864-87-4 | C17H16FN3 | 1 ML
RS-127445 is a selective, high affinity, and orally bioavailable 5-HT2B receptor antagonist. It demonstrates a pKi of 9.5 and exhibits over 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites.
- Selective 5-HT2B receptor antagonist
- High affinity (pKi of 9.5)
- Orally bioavailable
- Over 1000-fold selectivity compared to other receptors
- Potently blocks 5-HT evoked increases in intracellular calcium concentrations
Medchemexpress LLC Y-33075 dihydrochloride | 173897-44-4 | 98.8% | 353.25 | 50 MG
Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM. It also inhibits PKC and CaMKII, and has shown effects in extending neurites in retinal ganglion cells and lowering intraocular pressure.
- Potent and selective ROCK inhibitor
- Inhibits PKC and CaMKII
- Extends neurites in retinal ganglion cells
- Lowers intraocular pressure
- Increases regenerating axons
Medchemexpress LLC VU 0240551 | 893990-34-6 | 99.7% | 342.44 | 50 MG
VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) that exhibits selectivity over NKCC1. It also acts as an inhibitor of hERG and L-type Ca2+ channels. This compound reduces GABA-induced hyperpolarization of P cells, leading to a positive shift in the P cell GABA reversal potential and an enhancement of P cell synaptic transmission. It is intended for research use only.
- Potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM)
- Selective against NKCC1
- Inhibits hERG and L-type Ca2+ channels
- Attenuates GABA-induced hyperpolarization of P cells
- Produces a positive shift in the P cell GABA reversal potential
- Enhances P cell synaptic transmission
Medchemexpress LLC Zm323881 hydrochloride | 193000-39-4 | C22H19ClFN3O2 | 25 MG
ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. This anilinoquinazoline potently inhibits VEGFR2 (KDR) tyrosine kinase activity, showing excellent selectivity over other receptor tyrosine kinases. It inhibits VEGF-A-induced endothelial cell proliferation and VEGFR2 tyrosine phosphorylation.
- Potent and selective VEGFR2 inhibitor (IC50 < 2 nM)
- Inhibits VEGFR2 (KDR) tyrosine kinase activity
- Excellent selectivity over other receptor tyrosine kinases
- Inhibits VEGF-A-induced endothelial cell proliferation (IC50 = 8 nM)
- Inhibits VEGFR2 tyrosine phosphorylation
- Blocks activation of VEGFR-2, while sparing VEGFR-1, EGFR, PDGFR, and HGF receptor
- For research use only
Medchemexpress LLC PXS-6302 hydrochloride | 2584947-79-3 | C10H11ClF3NO2S | 1 MG
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor. It demonstrates high permeability across cell monolayers and reduces collagen deposition. This compound has shown significant improvement in scar appearance in porcine models of excisional and burn injury under topical application.
- Irreversible lysyl oxidase inhibitor
- Reduces collagen deposition
- Significantly improves scar appearance
- Readily skin penetrability
eMolecules 1788058-41-2 | (R)-4-AMINOPYRROLIDIN-2-ONE HCL | MFCD20257112 | 1g
Medchem Express | Trametiglue | 5mg | 791206436 | HY-153181 | 2666940-97-0 | 666.470 | C25H24FIN6O5S
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Medchemexpress LLC Drp1i27 (dihydrochloride) | C20H28Cl2N6O | 25 MG
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1 through hydrogen bonds to Gln34 and Asp218. This product targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Potent inhibitor of human Drp1 (dynamin-related protein 1)
- Binds to the GTPase site of Drp1
- Targets Drp1-mediated mitochondrial fission in cell line models
- Protects against simulated ischemia-reperfusion injury
- Increases cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner
Medchemexpress LLC Bay-6672 hydrochloride | 2247520-31-4 | 98.0% | 581.33 | C26H28BrCl2N3O3 | 5 MG
BAY-6672 hydrochloride is a research-grade small molecule antagonist of the human Prostaglandin F (FP) receptor with a reported IC50 of 11 nM. Supplied as the hydrochloride salt and characterized at high purity, it is intended for in vitro pharmacology and biochemical studies and is available as a solid or as a 10 mM solution in DMSO. For research use only; not for human or clinical use.
- Potent FP receptor antagonist (IC50 = 11 nM).
- High purity suitable for pharmacological assays.
- Available as solid mg quantities and as a 10 mM DMSO solution.
- Characterized molecular weight and formula for identification.
- Intended for in vitro research use only.
Medchemexpress LLC Verubulin hydrochloride | 917369-31-4 | 98.7% | 10 MG
Verubulin hydrochloride is the hydrochloride salt of verubulin, a blood-brain barrier-permeable microtubule-disrupting agent used in research for studies of tubulin polymerization, microtubule dynamics, and anticancer pharmacology. It is supplied as a high-purity research reagent for in vitro and in vivo studies.
- Blood-brain barrier permeable microtubule disruptor.
- Potent, broad-spectrum cytotoxic and antitumor activity.
- Hydrochloride salt form.
- Available in multiple pack sizes, including 10 mg.
- High purity suitable for research applications.
Medchemexpress LLC Nitrocaramiphen hydrochloride | 98636-73-8 | 99.6% | 370.87 g/mol | C18H27ClN2O4 | 5 MG
Nitrocaramiphen hydrochloride is a selective muscarinic M1 receptor antagonist (Ki: 5.5 nM) that inhibits the hyperpolarizing effect induced by muscarine in muscle fibers. It is supplied as a high-purity solid for in vitro pharmacological and biochemical research.
- Selective M1 receptor antagonist (Ki: 5.5 nM).
- High reported purity (~99.6%).
- Solid form suitable for handling and formulation.
- Soluble in DMSO (10 mg/mL) and water with heating and sonication.
- Recommended storage: sealed, away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
![Medchemexpress LLC N-[3-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide | 1135243-19-4 | MFCD18086889 | 99.8% | 432.52 | C18H20N6O3S2 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000241984.png-250.jpg)
Medchemexpress LLC N-[3-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide | 1135243-19-4 | MFCD18086889 | 99.8% | 432.52 | C18H20N6O3S2 | 100 MG
VU 0255035 is a selective and competitive M1 muscarinic acetylcholine receptor (M1 mAChR) antagonist used as a research tool to probe M1 signaling and neuronal excitability in central nervous system disease models.
- Selective, competitive M1 muscarinic receptor antagonist.
- Brain-penetrant compound suitable for CNS studies.
- High purity, approximately 99.8%.
- Molecular weight 432.52 g/mol; chemical formula C18H20N6O3S2.
- Appearance: solid, light yellow to brown; supplied as 100 MG quantities.
- Used in research related to epilepsy, Parkinson's disease, and dystonia.
Med Vet International Terbinafine Hcl (Lamisil) 250mg Tablet White Round 30 Tablets
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Terbinafine HCL (Lamisil) 250mg Tablet White Round 30 Tablets.
Medchemexpress LLC IACS-9571 hydrochloride | 2319611-93-1 | 98.3% | 679.22 g/mol | C32H43ClN4O8S | 1 ML
IACS-9571 hydrochloride is a potent, selective small-molecule inhibitor of the bromodomain proteins TRIM24 and BRPF1. It is used in biochemical and cellular research to probe bromodomain function, assess target engagement, and study downstream epigenetic regulation in vitro and in cells.
- Potent TRIM24 inhibition (IC50 = 8 nM) and strong BRPF1 binding (Kd = 14 nM).
- Demonstrates cellular activity (EC50 ≈ 50 nM).
- High purity suitable for research applications (>98% reported by supplier).
- Available as a 10 mM solution in DMSO (1 mL) and as solid quantities for custom preparation.
- Molecular formula C32H43ClN4O8S; molecular weight 679.22 g/mol.
Medchemexpress LLC CCT365623 hydrochloride | 2126136-98-7 | 98.1% | 443.99 | C18H18ClNO4S3 | 10MM 1ML
CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor supplied as a high-purity research reagent. It is available as solids and as a 10 mM solution in DMSO for use in biochemical and cellular assays, with molecular weight 443.99 g/mol and chemical formula C18H18ClNO4S3. Typical applications include LOX inhibition studies, signaling pathway research, and preclinical investigations.
- High purity, 98.1%.
- Available as 10 mM solution in DMSO (1 mL) and as solids (5-100 mg).
- Soluble in DMSO; ultrasonic agitation may improve dissolution.
- Molecular weight 443.99 g/mol.
- Suitable for biochemical and cellular LOX inhibition assays.
- Provided with certificate of analysis for batch verification.
- CAS number 2126136-98-7 for unambiguous identification.