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Vevorisertib trihydrochloride is a selective, allosteric inhibitor targeting pan-AKT and the AKT1-E17K mutant. It potently inhibits the phosphorylation of AKT, making it a valuable compound for cancer research applications.
Potently inhibits phosphorylation of AKT
Selective pan-AKT and AKT1-E17K mutant inhibitor
Exhibits anti-proliferative effects in various cancer cell lines
Induces cell cycle arrest and increased cell death when combined with imatinib mesylate
Demonstrates tumor growth inhibition in mouse xenograft models
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