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Losartan Potassium (DuP 753 CAS 124750-99-8) is a small molecule antagonist selective toward angiotensin AT receptors By competitively blocking AT receptors it inhibits angiotensin II-mediated vasoconstriction demonstrated by antagonism of contractile responses in isolated rabbit aortic and jugular vein tissues (pA 8 27) As an orally bioavailable agent losartan potassium is frequently utilized in cardiovascular research notably in studies investigating hypertension and associated mechanisms of angiotensin II signaling
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