Molecular Formula C13H9ClN2O3, Purity ≥98%, Formula Weight 276.7, Synonyms: 2-chloro-5-nitrobenzanilide; The peroxisome proliferator-activated receptor (PPAR) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPAR agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPAR agonists, including 15-deoxy-.DELTA.12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. GW 9662 blocks the PPAR-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 M. It is therefore a much more potent antagonist than BADGE, which is another reported PPAR antagonist.