Organoiodides

Medchemexpress LLC Ethyl 4-(5-acrylamido-2-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate | 1918238-72-8 | 99.8% | 354.34 g/mol | C18H15FN4O3 | 1 MG

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JAK 3i is a selective, covalent inhibitor of Janus kinase 3 (JAK3) used as a research tool to study JAK/STAT signaling and immune biology. It potently inhibits JAK3 (IC50: 0.43 nM), forms a covalent bond with a cysteine residue in JAK3, and abolishes IL-2-driven T-cell proliferation in vivo.

• Potent JAK3 inhibition (IC50: 0.43 nM).
• Covalent mechanism targeting a cysteine residue in JAK3.
• High selectivity versus related kinases.
• Suitable for immunology and autoimmune disease research.
• High purity for biochemical assays (HPLC 99.8%).
• Available in small research quantities.