Metal Aryls
Medchemexpress LLC ABT-639 | 1235560-28-7 | 99.3% | 455.91 | 5 MG
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. It is for research use only and not sold to patients.
- Novel, peripherally acting, selective T-type Ca2+ channel blocker.
- Blocks recombinant human T-type (Cav3.2) Ca2+ channels (IC50=2 μM).
- Attenuates low voltage-activated (LVA) currents in rat DRG neurons (IC50=8 μM).
- Less active at other Ca2+ channels (e.g., Cav1.2, Cav2.2) (IC50>30 mM).
- High oral bioavailability (%F=73), low protein binding (88.9%), low brain:plasma ratio (0.05:1) in rodents.
- Produces dose-dependent antinociception in rat model of knee joint pain (ED50=2 mg/kg, p.o.).
- Increases tactile allodynia thresholds in multiple models of neuropathic pain (10-100 mg/kg, p.o.).
- Does not attenuate hyperalgesia in inflammatory pain models.
- Does not significantly alter hemodynamic or psychomotor function at higher doses (e.g., 100-300 mg/kg).
Medchemexpress LLC ABT-639 | 1235560-28-7 | 99.3% | 455.91 | 50 MG
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. It is used for research purposes only and not sold to patients. It effectively reduces nociceptive and neuropathic pain in rats.
- Blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion.
- Attenuates low voltage-activated (LVA) currents in rat DRG neurons.
- Significantly less active at other Ca2+ channels (e.g., Cav1.2 and Cav2.2).
- High oral bioavailability (%f=73) in rodents.
- Low protein binding (88.9%) in rodents.
- Low brain:plasma ratio (0.05:1) in rodents.
- Produces dose-dependent antinociception in a rat model of knee joint pain.
- Increases tactile allodynia thresholds in multiple models of neuropathic pain.
- Does not significantly alter hemodynamic or psychomotor function at higher doses.
![Medchemexpress LLC 5-(hexahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-4-chloro-2-fluoro-N-(2-fluorophenyl)benzenesulfonamide | 1235560-28-7 | MFCD29924737 | 99.3% | 457.48 g/mol | C20H20ClF2N3O3S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000294773.png-250.jpg)
Medchemexpress LLC 5-(hexahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-4-chloro-2-fluoro-N-(2-fluorophenyl)benzenesulfonamide | 1235560-28-7 | MFCD29924737 | 99.3% | 457.48 g/mol | C20H20ClF2N3O3S | 10 MG
ABT-639 is a peripherally acting, selective T-type Ca2+ (CaV3.2) calcium channel blocker supplied as a research reagent. It has been investigated for analgesic and antihyperalgesic activity in preclinical and clinical studies and is provided as a high-purity solid for laboratory use.
- Peripherally acting T-type Ca2+ channel blocker.
- Selective for CaV3.2 T-type channels.
- High purity suitable for research applications.
- Supplied as a solid, convenient for formulation and dosing.
- Intended for in vitro and in vivo research use; not for human use.
Frontier Specialty Chemicals 100G 2-(TRIBUTYLSTANNYL)PYRIDI
100g 2-(tributylstannyl)pyridi. 17997-47-6
Sigma Aldrich Fine Chemicals Biosciences Triphenylantimony(V) dichloride 99% | 594-31-0 | MFCD00013598 | 5G
Triphenylantimony(V) dichloride 99% | Purity: 99% | Mol Wt: 423.98 | 594-31-0 | MFCD00013598 | 5G
Strem, An Ascensus Company CAS# 603-36-1. 10g. Triphenylantimony, 97%. MFCD00003000
CAS# 603-36-1. 10g. Triphenylantimony, 97%. MFCD00003000. Molecular Weight: 353.07. Molecular Formula: (C6H5)3Sb. Color/form: off-white xtl. Strem# 51-3000. http://www.strem.com/catalog/v/51-3000/
Medchemexpress LLC Titanocene dichlorid 25g | 1271-19-8 | 25G
Titanocene dichloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research
TARGETMOL CHEMICALS INC ABT-639 10MG
Also available in 1 mg, 2 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. ABT-639 is a potent and selective T-type calcium channel blocker.
Medchemexpress LLC Obidoxime dichloride | 114-90-9 | 96.6% | 359.21 | 10 MG
Obidoxime dichloride is a non-full spectrum oxime agent used as an antidote for organophosphate nerve agent poisoning. It reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces the acute toxicity of sarin. It is for research use only and not sold to patients. In vivo, obidoxime dichloride (intramuscular injection; 10 mg/kg; after 60 mins) exhibits an LD50 of 57.7 mg/kg after administration of sarin, and it reduces the acute toxicity of sarin.
- Used as an antidote for organophosphate nerve agent poisoning
- Reactivates sarin-inhibited acetylcholinesterase (AChE)
- Reduces the acute toxicity of sarin
- Off-white to light yellow solid appearance
- Soluble in water and DMSO
- Ships at room temperature in continental US
- Storage conditions: -20°C, protect from light, stored under nitrogen
Frontier Specialty Chemicals 5G 2-(TRIBUTYLSTANNYL)PYRIDINE
This item has a minimum qty of 3 per supplier requirements.
2-(Tributylstannyl)pyridine; CAS No: 17997-47-6