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Filtered Search Results
Medchemexpress LLC Ms-PEG5-t-butyl ester | 870487-48-2 | C16H32O9S | 50 MG
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Ms-PEG5-t-butyl ester is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase, and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system.
- Used to selectively degrade target proteins.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC 3,6,9,12,15-Pentaoxaheptadecane, 1,17-diazido- | 356046-26-9 | 100.0% | 332.36 | 250 MG
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Azido-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Azide group. It can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. This product is intended for research use only.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Reacts with alkyne-containing molecules
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Reacts with molecules containing DBCO or BCN groups
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Medchemexpress LLC N-Boc-C1-PEG3-C3-NH2 | 194920-62-2 | 320.42 | 10 G
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N-Boc-C1-PEG3-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC N-Boc-PEG5-bromide | 1392499-32-9 | MFCD31536756 | 98.0% | 400.31 g/mol | C15H30BrNO6 | 1 G
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N-Boc-PEG5-bromide is a Boc-protected polyethylene glycol (PEG5) bromide linker reagent used in organic synthesis for assembling antibody-drug conjugate (ADC) and proteolysis-targeting chimera (PROTAC) linkers. It supplies a protected amine and a reactive terminal bromide for nucleophilic substitution and coupling reactions, and is provided at high purity for research use.
- Provides a Boc-protected amine for temporary protection during synthesis.
- Offers a terminal bromide suitable for nucleophilic substitution and coupling reactions.
- PEG5 spacer increases solubility and flexibility in linker constructs.
- High purity appropriate for research and linker assembly.
- Stable under recommended storage conditions for extended shelf life.
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eMolecules 139115-92-7 | Boc-NH-PEG3 | Ambeed | MFCD07357496 | 249.307 | C11H23NO5 | 97.000 | CC(C)(C)OC(=O)NCCOCCOCCO | 5g | 552604531
Boc-NH-PEG3 | Ambeed | 139115-92-7 | MFCD07357496 | 249.307 | C11H23NO5 | 97.000 | CC(C)(C)OC(=O)NCCOCCOCCO | 5g | 552604531
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Medchemexpress LLC Azide-PEG5-Boc | 1415800-41-7 | C17H33N3O7 | 500 MG
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Azide-PEG5-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. PROTACs are designed to selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Utilizes the intracellular ubiquitin-proteasome system to degrade target proteins
- For research use only
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Ethanamine, 2-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethoxy]- | 1261350-60-0 | 95.0% | 267.79 | 25 MG
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NH2-PEG3-C6-Cl is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets a specific protein. This mechanism leverages the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC M-PEG3-OMs | 74654-05-0 | >98% | C8H18O6S | 250 MG
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This product is m-PEG3-OMs, a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Azido-PEG5-acid | 1425973-16-5 | >98.0% | 335.35 | C13H25N3O7 | 10 G
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Azido-PEG5-acid is an azide-terminated five-unit polyethylene glycol (PEG5) acid linker used for bioconjugation and linker synthesis. It functions as a click-chemistry reagent capable of undergoing azide-alkyne cycloaddition reactions and is commonly used in PROTAC and antibody-drug conjugate assembly.
- Azide functional group enables copper-catalyzed and strain-promoted click reactions.
- Five-unit PEG spacer provides solubility and flexibility for conjugation.
- High purity supports synthetic and bioconjugation applications.
- Available in multiple pack sizes for scalable workflows.
- Stable under recommended storage conditions to preserve reactivity.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC m-PEG3-succinimidyl carbonate | 477775-77-2 | 99.4% | C12H19NO8 | 100 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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m-PEG3-succinimidyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase
- The other ligand for the target protein
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC m-PEG3-azide | 74654-06-1 | MFCD00020141 | >98% | C7H15N3O3 | 250 MG
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m-PEG3-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, enabling it to participate in various cycloaddition reactions.
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne groups.
- Can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
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Medchemexpress LLC Tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate | 252881-73-5 | 303.3547 g/mol | C13H25N3O5 | 50 MG
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N3-PEG3-CH2CH2-Boc is an azido-terminated PEG3 linker with a tert-butyl (Boc) protected carboxylic acid end, used as a cleavable PEG-based linker in antibody-drug conjugate and PROTAC synthesis, and as an azide reagent for click chemistry.
- Azide-terminated PEG3 linker suitable for click chemistry.
- tert-Butyl (Boc) protected carboxyl end for orthogonal deprotection.
- Used in ADC and PROTAC linker assembly.
- Available as a small pre-weighed laboratory pack for synthetic use.
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Medchemexpress LLC (S)-17-(4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-14-oxo-4,7,10-trioxa-13-azaoctadecane-1,18-dioic acid | 97.6% | C28H36N8O10 | 5 MG
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Folate-PEG3-C2-acid is an acid fragment and PEG-type PROTAC linker used in the synthesis of Proteolysis-targeting Chimeras. It has a molecular weight of 644.63 and a purity of 97.56%.
- Stable under recommended storage conditions
- Consistent with structure based on 1H NMR Spectrum and LCMS
- Solid appearance
- For research use only
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Medchemexpress LLC 2-(2-(2-bromoethoxy)ethoxy)ethyl methanesulfonate | 2702323-73-5 | 95.0% | C7H15BrO5S | 10MG
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A PEG-based bifunctional linker with a bromide and a methanesulfonate functional group, designed for use in the synthesis and assembly of PROTAC molecules. It provides a short, flexible PEG3 spacer to connect ligands while enabling nucleophilic substitution chemistry.
- Provides a short PEG3 spacer for flexibility and solubility.
- Contains terminal bromide and methanesulfonate groups that act as leaving groups for conjugation.
- Suitable for linker assembly and PROTAC synthesis via nucleophilic substitution.
- High research-grade purity for consistent performance.
- Available in small research sizes and supplied as a liquid for ease of handling.
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Medchemexpress LLC Azido-PEG3-alcohol | 86520-52-7 | MFCD09753542 | 98.2% | 175.19 g/mol | C6H13N3O3 | 500 MG
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Azido-PEG3-alcohol is a PEG-based linker bearing a terminal azide and a terminal hydroxyl group. It is used as a click-chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and as a flexible spacer in PROTACs and bioconjugation workflows.
- Terminal azide enables copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Terminal hydroxyl allows further functionalization and conjugation.
- PEG3 spacer imparts hydrophilicity and flexible linkage between molecules.
- High purity suitable for synthetic and bioconjugation applications.
- Stable when stored at -20°C in pure form; solution stability is limited.
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