Organo-Metalloid Compounds
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Filtered Search Results
Medchemexpress LLC PS-1145 | 431898-65-6 | 99.67% | 322.75 | 100 MG
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PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM, functioning to block TNFα-induced NF-κB activation by inhibiting IκBα phosphorylation in multiple myeloma (MM) cells. This inhibition is observed in a dose- and time-dependent manner. It also enhances the blockade of NF-κB activation when combined with Dexamethasone, and can inhibit the protective effect of IL-6 against Dexamethasone-induced apoptosis.
- Potent inhibitor of IKK activity.
- Blocks phosphorylation of IκBα.
- Inhibits TNFα-induced NF-κB activation.
- Reduces TNFα-induced intracellular adhesion molecule (ICAM)-1 expression.
- Demonstrates antiproliferative activity against certain human cells.
- Decreases serum levels of specific cytokines in vivo.
- Can block inflammation-induced weight gain during high-fat feeding.
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Medchemexpress LLC AK-778-XXMU | 1227045-76-2 | 99.9% | C22H17ClN2O3 | 1 ML
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AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. It can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and exhibits significant cancer-suppressing potency. The compound acts by inhibiting the ID2-KDR signaling axis, leading to the down-regulation of angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), and the up-regulation of the tumor suppressor factor (PTEN). It is suitable for the study of glioma.
- Potent ID2 antagonist with a KD of 129 nM
- Inhibits cell migration and invasion in glioma cell lines
- Induces apoptosis
- Exhibits significant cancer-suppressing potency
- Down-regulates angiogenic factors (VEGFA)
- Down-regulates invasion-related proteins (MMP2/9)
- Up-regulates tumor suppressor factor (PTEN)
- Inhibits tumor growth in U87 glioma xenograft mice model
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Medchemexpress LLC AK-778-XXMU | 1227045-76-2 | 99.9% | C22H17ClN2O3 | 25 MG
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AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. It inhibits the ID2-KDR signaling axis, leading to the down-regulation of downstream angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), while up-regulating the tumor suppressor factor (PTEN). It can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and demonstrates significant cancer-suppressing potency. This compound is used for the study of glioma.
- Potent DNA binding inhibitor 2 (ID2) antagonist
- Inhibits cell migration and invasion of glioma cell lines
- Induces apoptosis
- Demonstrates significant cancer-suppressing potency
- Inhibits ID2-KDR signaling axis
- Down-regulates angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9)
- Up-regulates tumor suppressor factor (PTEN)
- Suitable for the study of glioma
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![eMolecules 280752-78-5 | (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol | MFCD10699559 | 250mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502138417.JPG-250.jpg)
eMolecules 280752-78-5 | (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol | MFCD10699559 | 250mg
Medchem Express | Delphinidin 3-glucoside (chloride) | 1mg | 632433155 | HY-108052 | 6906-38-3 | MFCD01762899 | 500.840 | C21H21ClO12
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Apexbio Technology LLC PS-1145 431898-65-6 25mg
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PS-1145 (CAS 431898-65-6) is a selective inhibitor of I B kinase (IKK) with an IC50 of 88 nM IKK is a critical component of the upstream NF- B signaling pathway regulating cellular responses to inflammation In vitro studies have demonstrated that PS-1145 blocks TNF -induced NF- B activation in multiple myeloma (MM) cells in a dose- and time-dependent manner increases I B protein levels suppresses IL-6-mediated anti-apoptotic effects and inhibits expression of ICAM-1 Additionally PS-1145 reduces IL-6 secretion from bone marrow stromal cells (BMSCs) and partially limits MM cell proliferation In vivo PS-1145 has been shown to induce apoptosis in DMBA-induced skin tumors in rats by inhibiting NF- B and VEGF activity The compound remains in the preclinical research stage
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eMolecules 5-TRIMETHYLSILANYLTHIAZOLE | 79265-36-4 | 5G | Purity: 97%
AstaTech | 5-TRIMETHYLSILANYLTHIAZOLE | 5G | 79265-36-4 | MFCD00191506
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![Medchemexpress LLC 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-methanol | 1374639-77-6 | 99.0% | 251.72 | 100 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000404382-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-methanol | 1374639-77-6 | 99.0% | 251.72 | 100 G
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2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-methanol is a drug intermediate used in the synthesis of various active compounds. This product is intended for research purposes only and is not suitable for patient use.
- Drug intermediate for synthesis of various active compounds.
- Intended for research use only.
- Available in multiple quantities.
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eMolecules EMOLECULES INC
5000191411 TERT-BUTYL-2-IODOETHOXY 500MG
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eMolecules 2-DICHLOROMETHYL-4 4 5 5 25G
5000217339 2-DICHLOROMETHYL-4 4 5 5 25G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000403744 2-CHLORO-7-CYCLOPENT 50G
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Medchemexpress LLC 3-METHYL-2-CYCLOPENT 25G | 25G
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3-METHYL-2-CYCLOPENT 25G | 25G
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eMolecules EMOLECULES INC
5000493341 2-DICHLOROMETHYL-4 4 5 5 10G
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Medchemexpress LLC N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride | 35141-36-7 | MFCD00054225 | 50% in methanol (solution) | C9H24ClNO3Si | 500 MG
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N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride, supplied as a 50% solution in methanol, is a biochemical reagent. It is suitable for use as a biological material or organic compound in life science research and is intended for research use only.
- Suitable for life science research
- Supplied as a 50% solution in methanol
- Liquid appearance, colorless to light yellow
- Store at -20°C, protected from light
- Stable for 2 years when stored correctly
- For research use only
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules (Bromodifluoromethyl)triphenylphosphonium bromide | 58201-66-4 | MFCD00191843 | 1g
Combi-Blocks | (Bromodifluoromethyl)triphenylphosphonium bromide | 1g | 495746774 | QH-4540 | 95.000 | 58201-66-4 | MFCD00191843 | 472.108 | C19H15Br2F2P
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eMolecules Building Block Tool
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules 2-(Bromodifluoromethyl)-1,3-benzoxazole | 186828-50-2 | MFCD11035866 | 1g
Apollo Scientific | 2-(Bromodifluoromethyl)-1,3-benzoxazole | 1g | 562460132 | PC32712 | | 186828-50-2 | MFCD11035866 | 248.027 | C8H4BrF2NO
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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