Dimethyl Sulfoxide
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Apexbio Technology LLC BMN 673 1207456-01-6 10mM (in 1mL DMSO)
BMN 673 (CAS 1207456-01-6) is a small-molecule inhibitor selectively targeting poly(ADP-ribose) polymerase isoforms PARP1 and PARP2 enzymes crucial for DNA repair pathways BMN 673 demonstrates potent inhibition with reported Ki values of 1 2 nM and 0 9 nM against PARP1 and PARP2 respectively and minimal off-target interactions across diverse receptors ion channels and enzymes In preclinical studies BMN 673 displayed substantial antitumor activity in tumor cells and xenograft models exhibiting homologous recombination repair deficits with enhanced efficacy noted in combination with DNA-damaging agents Currently BMN 673 is under clinical investigation in advanced solid tumors and hematological malignancies
