Dimethyl Sulfoxide
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Apexbio Technology LLC SAG(Synonyms: Smoothened Agonist, SAG dihydrochloride, Hh-Smo agonist, SAG hydrochloride), 10mM (in 1mL DMSO), CAS: 912545-86-9.
SAG (CAS 912545-86-9) is a synthetic small-molecule agonist targeting the Smoothened (SMO) receptor a GPCR-like protein central to the Hedgehog (Hh) signaling pathway It activates SMO with an EC50 of approximately 3 nM thus stimulating downstream Gli transcription factor activity involved in embryonic development and adult tissue homeostasis At concentrations above 1 M SAG exhibits inhibitory effects on pathway signaling It binds directly to SMO forming an interaction with a reported dissociation constant (K D) around 59 nM SAG is employed in biomedical research notably to mitigate glucocorticoid-induced cerebellar injury in primary mouse neuronal cell cultures
