Dimethyl Sulfoxide
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Apexbio Technology LLC RG7388 1229705-06-9 10mM (in 1mL DMSO)
RG7388 (CAS 1229705-06-9) is a second-generation selective inhibitor of the MDM2-p53 interaction It functions by blocking the binding between MDM2 and wild-type p53 thereby stabilizing and activating the p53 tumor-suppressor pathway In human cancer cell lines RG7388 shows high potency with reported IC50 values of 6 nM (MDM2 binding assay) and 0 03 M (MTT assay) Preclinical studies demonstrate cell-cycle arrest and apoptosis selectively in wild-type p53-expressing cells and tumor regression in xenograft mouse models including sarcoma and neuroblastoma RG7388 is currently under clinical evaluation for multiple solid and hematologic malignancies
