Dimethyl Sulfoxide
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Apexbio Technology LLC (+)-Apogossypol 66389-74-0 10mM (in 1mL DMSO)
( )-Apogossypol (CAS 66389-74-0) is a pan-BCL-2 family protein antagonist exhibiting activity against anti-apoptotic proteins including Bcl-2 Bcl-xL and Mcl-1 By binding directly to these targets it inhibits their anti-apoptotic functions thereby promoting apoptosis Reported EC50 values for binding to Mcl-1 Bcl-2 and Bcl-xL are 2 6 M 2 8 M and 3 69 M respectively This compound is utilized in research focused on apoptosis signaling pathways and cancer drug screening involving the BCL-2 protein family
