Dimethyl Sulfoxide
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Apexbio Technology LLC Ro 3306 872573-93-8 10mM (in 1mL DMSO)
Ro 3306 (CAS 872573-93-8) is an ATP-competitive inhibitor targeting cyclin-dependent kinase 1 (CDK1) It selectively inhibits CDK1/cyclin B1 and CDK1/cyclin A complexes (Ki values of 35 nM and 110 nM respectively) thereby interfering with mitotic entry In DU145 cells Ro 3306 at 1 M diminishes BRCA1 localization at DNA double-strand breaks and suppresses RAD51 foci formation sensitizing these cells to DNA-damaging agents such as AZ12253801 Hence Ro 3306 is useful in studying cell cycle regulation DNA repair mechanisms and sensitization of cancer cells to targeted therapies
