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Synthesized from the 5-carbon precursors isopentenyl diphosphate and dimethylallyl diphosphate; includes the carotenoids, which are precursors of vitamin A and also possess antioxidant effects.
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Ursolic acid acetate (Acetylursolic acid) is a triterpenoid compound and an inhibitor of *Plasmodium falciparum* heat shock protein 90 (PfHsp90) with a KD of 8.16 μM. It is cytotoxic to KB cells, with an IC50 value of 8.4 μM. Ursolic acid acetate can be used in tumor and antimalarial research.
Triterpenoid compound
Inhibitor of Plasmodium falciparum heat shock protein 90 (PfHsp90) (KD = 8.16 μM)
Cytotoxic to KB cells (IC50 = 8.4 μM)
Potential for use in tumor and antimalarial research
Can reduce the ATPase activity of PfHsp90 in a dose-dependent manner (1-5 mM; 4.5 h)
Has an IC50 of 24.93 μM against the P. falciparum FcB1 strain
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Macupatide acetate is a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. It is used in the research of type 2 diabetes by improving insulin secretion responses and insulin sensitivity. Preclinical studies suggest it reduces body weight and fasting blood glucose.
Improves insulin secretion responses
Improves insulin sensitivity
Produces larger insulin sensitivity improvement compared to selective GLP-1 RA dulaglutide
Combination therapy with GLP-1 RA dulaglutide had additive effects on insulin sensitivity
Reduces body weight in patients with type 2 diabetes
Reduces fasting blood glucose in patients with type 2 diabetes
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Antitumor and anti-HIV agent. Induces apoptosis by activating mitochondrial permeability transition (MPT). Inhibits NF-κB activation and NF-κB-regulated gene expression induced by carcinogens and inflammatory stimuli. Decreases expression of Bcl-2 and cyclin D1. Potent proteasome activator. Alternative name: 3beta-Hydroxy-20(29)-lupaene-28-oic acid. Purity: ≥90% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in DMSO. Long Term Storage: +4°C.
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Antioxidant agent-4 (1,3-benzodioxol-5-ol, 7-methoxy-) is a small-molecule antioxidant reported to have antilipid peroxidative activity and is supplied for research use as solids and as a DMSO solution.
Antilipid peroxidative activity.
CAS number 50901-34-3.
Purity 96.0%.
Chemical formula C8H8O4 and molecular weight 168.15 g/mol.
High solubility in DMSO (100 mg/mL; ultrasonic may be required).
Storage: solid at 4°C under nitrogen; in solvent store at -80°C (6 months) or -20°C (1 month).
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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γ-Tocopherol is a chemical compound primarily intended for use as a laboratory chemical and in the manufacture of substances. This product is for research use only and has not been fully validated for medical applications. It is stable under recommended storage conditions.
Intended for laboratory use.
Stable under recommended storage conditions.
Recommended storage at 4°C, protected from light.
For shipping, can be at room temperature if less than 2 weeks.
Keep container tightly sealed in a cool, well-ventilated area.
Keep away from direct sunlight and sources of ignition.
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18α-Glycyrrhizic acid, a derivative of Glycyrrhizic acid, exhibits weak antihepatotoxic and anti-inflammatory activities. This white to off-white solid is supplied for research purposes and has a purity of 99.79%.
Derivative of glycyrrhizic acid
Exhibits weak antihepatotoxic activity
Exhibits weak anti-inflammatory activities
Supplied as a white to off-white solid
Purity of 99.79%
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nor-NOHA (acetate) (CAS 1140844-63-8) is a potent reversible inhibitor of rat liver arginase (Ki 0 5 M) By competitively inhibiting arginase nor-NOHA modulates the cellular balance between the L-arginine-dependent pathways of nitric oxide synthase (NOS) and arginase affecting nitric oxide production and urea cycle metabolism In vitro studies have shown that nor-NOHA suppresses proliferation migration and invasion of HepG2 hepatocellular carcinoma cells induces apoptosis and alters expression of Arg1 MMP-2 P53 and ECD In vivo nor-NOHA improves endothelial function in rat models of inflammation by enhancing NOS activity increasing EDHF and reducing superoxide anion production This compound is widely used to investigate arginase-related mechanisms in cellular and vascular biology
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Abscisic acid (S)-(+)- is a naturally occurring plant hormone supplied as a research-grade analytical standard. It is used to study plant growth regulation, signaling pathways, and stress responses, and is provided as a solid suitable for biochemical assays and metabolic studies.
Research-grade analytical standard for plant biology studies.
High purity: 99.7%.
Molecular formula C15H20O4; molecular weight 264.32 g/mol.
Supplied as a 500 MG solid for laboratory use.
Suitable for biochemical assays and metabolic studies.
Common applications: plant growth and stress-response research.
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