Organoheterocyclic compounds
Medchemexpress LLC 2-piperidinecarboxylic acid ester linked to SLF and thalidomide-based cereblon ligand | 1799711-22-0 | 98.0% | 1009.11 g/mol | C53H64N6O14 | 10 MG
dFKBP-1 is a PROTAC small molecule designed to induce degradation of FKBP12 by linking an FKBP12-binding SLF ligand to a thalidomide-derived cereblon ligand via a tailored linker. It is supplied as a characterized research reagent for degrader studies.
- Potent PROTAC degrader of FKBP12 for cellular and biochemical studies.
- Contains an SLF-based FKBP12 ligand and a thalidomide-derived cereblon recruiter.
- High purity (98.0%) with 1H NMR and LCMS confirmation.
- Molecular weight ~1009.11 g/mol; formula C53H64N6O14.
- Off-white to light yellow solid; store at 4°C under inert gas; in solution store at -80°C (6 months) or -20°C (1 month).
Cayman Chemical PDM 2 Fatty Acids and Derivati
A resveratrol-based AhR antagonist (Ki = 1.2 nM); selectively binds to the AhR over the estrogen receptor at 100 µM
Cayman Chemical PDM 2 Fatty Acids and Derivati
A resveratrol-based AhR antagonist (Ki = 1.2 nM); selectively binds to the AhR over the estrogen receptor at 100 µM
Cayman Chemical PDM 2 Fatty Acids and Derivati
A resveratrol-based AhR antagonist (Ki = 1.2 nM); selectively binds to the AhR over the estrogen receptor at 100 µM
SPEX CERTIPREP LLC 3P 9-Chlorohexadecafluoro-3-oxanone-1-sulfonic acid potassium salt; 50 µg conj. base/mL in methanol; 1 mL
9-Chlorohexadecafluoro-3-oxanone-1-sulfonic acid potassium salt; 50 µg conj. base/mL in methanol; 1 mL
Sigma Aldrich Aquivion™ D98-25BS
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Apexbio Technology LLC Troxipide 30751-05-4 50mg
Troxipide is a gastric cytoprotective compound It is designed to promote mucus secretion enhance endogenous prostaglandin production and facilitate mucosal barrier repair thereby supporting gastrointestinal mucosal protection and regeneration Troxipide exerts its biological activity primarily through mucosal protective anti-ulcer and anti-inflammatory mechanisms independent of gastric or duodenal pH and without suppressing gastric acid secretion Based on these pharmacological properties Troxipide holds research potential in investigating gastrointestinal mucosal protection mechanisms mucosal regeneration pathways and inflammatory modulation in gastrointestinal disorders including ulcers and inflammatory mucosal injury models
Apexbio Technology LLC Troxipide 30751-05-4 10mM (in 1mL DMSO)
Troxipide is a gastric cytoprotective compound It is designed to promote mucus secretion enhance endogenous prostaglandin production and facilitate mucosal barrier repair thereby supporting gastrointestinal mucosal protection and regeneration Troxipide exerts its biological activity primarily through mucosal protective anti-ulcer and anti-inflammatory mechanisms independent of gastric or duodenal pH and without suppressing gastric acid secretion Based on these pharmacological properties Troxipide holds research potential in investigating gastrointestinal mucosal protection mechanisms mucosal regeneration pathways and inflammatory modulation in gastrointestinal disorders including ulcers and inflammatory mucosal injury models
Apexbio Technology LLC Prodan 70504-01-7 100mg
Prodan (CAS 70504-01-7) is a fluorescent dye utilized as an environment-sensitive probe in bio-membrane studies It enables analysis of membrane dynamics by exhibiting emission spectrum shifts in response to changes in local solvent polarity and membrane micro-environments Prodan exerts its biological activity primarily by functioning as a fluorophore sensitive to solvent orientation polarizability facilitating investigation of lipid organization membrane fluidity and protein interactions Modifications of Prodan have also enabled the synthesis of fluorescent nucleoside analogs for the study of cellular signaling and nucleic acid interactions Based on these properties Prodan holds research potential in cellular biology for elucidating membrane organization and signaling mechanisms
Apexbio Technology LLC Prodan 70504-01-7 25mg
Prodan (CAS 70504-01-7) is a fluorescent dye utilized as an environment-sensitive probe in bio-membrane studies It enables analysis of membrane dynamics by exhibiting emission spectrum shifts in response to changes in local solvent polarity and membrane micro-environments Prodan exerts its biological activity primarily by functioning as a fluorophore sensitive to solvent orientation polarizability facilitating investigation of lipid organization membrane fluidity and protein interactions Modifications of Prodan have also enabled the synthesis of fluorescent nucleoside analogs for the study of cellular signaling and nucleic acid interactions Based on these properties Prodan holds research potential in cellular biology for elucidating membrane organization and signaling mechanisms
Apexbio Technology LLC Prodan 70504-01-7 50mg
Prodan (CAS 70504-01-7) is a fluorescent dye utilized as an environment-sensitive probe in bio-membrane studies It enables analysis of membrane dynamics by exhibiting emission spectrum shifts in response to changes in local solvent polarity and membrane micro-environments Prodan exerts its biological activity primarily by functioning as a fluorophore sensitive to solvent orientation polarizability facilitating investigation of lipid organization membrane fluidity and protein interactions Modifications of Prodan have also enabled the synthesis of fluorescent nucleoside analogs for the study of cellular signaling and nucleic acid interactions Based on these properties Prodan holds research potential in cellular biology for elucidating membrane organization and signaling mechanisms
Apexbio Technology LLC Omeprazole 73590-58-6 10mM (in 1mL DMSO)
Omeprazole (73590-58-6) is a small-molecule inhibitor targeting H K -ATPase an enzyme essential for gastric acid secretion It is designed to inhibit the proton pump thereby reducing active transport of H ions into the gastric lumen Omeprazole exerts its biological activity primarily through irreversible binding to the H K -ATPase enzyme In in vitro studies Omeprazole demonstrates inhibitory activity with an IC value of approximately 5 8 M against purified H K -ATPase and an IC of 0 16 M in assays evaluating histamine-induced gastric acid production Based on these pharmacological properties Omeprazole holds research potential in the investigation of acid-mediated gastrointestinal conditions and related pathways
Apexbio Technology LLC Omeprazole 73590-58-6 100mg
Omeprazole (73590-58-6) is a small-molecule inhibitor targeting H K -ATPase an enzyme essential for gastric acid secretion It is designed to inhibit the proton pump thereby reducing active transport of H ions into the gastric lumen Omeprazole exerts its biological activity primarily through irreversible binding to the H K -ATPase enzyme In in vitro studies Omeprazole demonstrates inhibitory activity with an IC value of approximately 5 8 M against purified H K -ATPase and an IC of 0 16 M in assays evaluating histamine-induced gastric acid production Based on these pharmacological properties Omeprazole holds research potential in the investigation of acid-mediated gastrointestinal conditions and related pathways
Apexbio Technology LLC Lansoprazole 103577-45-3 10mM (in 1mL DMSO)
Lansoprazole (103577-45-3) is a small-molecule inhibitor targeting gastric H K -ATPase an enzyme responsible for gastric acid secretion via proton pump activity It is designed to inhibit H K -ATPase activity thereby suppressing gastric acid production Lansoprazole exerts its biological activity primarily through selective inhibition of the H K -ATPase enzyme In experimental models lansoprazole demonstrates inhibitory activity with an IC50 value of approximately 6 3 M for enzyme activity and 0 09 M for suppression of histamine-stimulated gastric acid secretion Based on these pharmacological properties lansoprazole holds research potential in studies of gastric acid-related pathophysiology gastroprotective mechanisms and ulcer formation processes
Medchemexpress LLC Cobomarsen | 1848257-52-2 | C148H177N52O77P13S13 | 10MG
Cobomarsen is a locked nucleic acid (LNA)-based antisense oligonucleotide that selectively inhibits microRNA-155 (miR-155). Supplied as a solid (white to off-white) research reagent, it is used in preclinical studies to modulate miR-155-driven signaling and investigate oncology models by affecting pathways such as JAK/STAT, MAPK/ERK, and PI3K/AKT. The sodium salt form offers improved stability; the compound is highly water soluble and requires sealed, moisture-free storage.
- Selective inhibition of miR-155 and related survival pathways
- Suitable for preclinical oncology and lymphoma research
- High aqueous solubility; may require ultrasonication
- Improved stability as the sodium salt compared with the free acid
- Store sealed and protected from moisture; long-term storage in solution at -80 °C