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Silver sulfadiazine (AgSD) is a sulfonamide antibiotic that exerts a dual inhibitory action on bacterial growth. Its sulfa moiety (SD-SDZ) prevents bacterial folate absorption and subsequent DNA synthesis. Additionally, the silver released from Silver sulfadiazine binds and disrupts the DNA structure, thereby precluding bacterial DNA replication.
Sulfonamide antibiotic
Exerts dual inhibitory action on bacterial growth
Prevents bacterial folate absorption and DNA synthesis
Disrupts bacterial DNA structure
Precludes bacterial DNA replication
Used in the research of bacterial infection in burns
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