Triterpenoids
Apexbio Technology LLC Glycyrrhizic acid 1405-86-3 20mg
Glycyrrhizic acid (CAS 1405-86-3) is a triterpenoid saponin antagonist targeting high mobility group box 1 (HMGB1) and inhibitor of monoamine oxidase (MAO) as well as cytochrome P450 enzymes (CYP3A4 CYP2C9 CYP2C19) and 11 -hydroxysteroid dehydrogenase type 2 (11 -HSD2) It is designed to antagonize HMGB1-mediated pro-inflammatory responses and oxidative stress inhibit the enzymatic activity of MAO and 11 -HSD2 and modulate cytochrome P450-mediated metabolism Glycyrrhizic acid exerts its biological activity primarily through competitive inhibition of these enzymes It demonstrates MAO inhibition with an IC50 of approximately 0 16 M and competitively inhibits CYP3A4 (IC50 8 2 M) CYP2C9 ( 42 9 M) and CYP2C19 ( 40 3 M) Based on these pharmacological properties glycyrrhizic acid holds research potential in anti-inflammatory pathways enzyme inhibition and glucose metabolic modulation
