Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride ReagentPlus(R), >=99% | 407-25-0 | MFCD00000416 | 3KG
Trifluoroacetic anhydride ReagentPlus(R), >=99% | Purity: >=99% | Mol Wt: 210.03 | 407-25-0 | MFCD00000416 | 3KG
Selleck Chemical LLC Z-LEHD-FMK TFA
Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable competitive and irreversible inhibitor of enzyme caspase-9 which helps in cell survival
Medchemexpress LLC ω-Agatoxin IVA TFA | 99.1% | 5316.27 | 5 MG
ω-Agatoxin IVA TFA is a potent and selective blocker of P/Q type Ca2+ (Cav2.1) channels. It exhibits IC50s of 2 nM for P-type and 90 nM for Q-type Ca2+ channels. The compound inhibits glutamate exocytosis and calcium influx, as well as the release of serotonin and norepinephrine, when elicited by high potassium. It does not affect L-type or N-type calcium channels.
- Potent and selective P/Q type Ca2+ (Cav2.1) channel blocker.
- IC50s of 2 nM for P-type and 90 nM for Q-type Ca2+ channels.
- Inhibits glutamate exocytosis and calcium influx.
- Blocks high potassium-induced release of serotonin and norepinephrine.
- Has no effect on L-type or N-type calcium channels.
Medchemexpress LLC Cyclo(Arg-Pro) TFA | 98.6% | 367.32 | 50 MG
Cyclo(Arg-Pro) TFA is identified as a chitinase inhibitor that impacts cell separation and morphological transitions in yeast by hindering chitinase activity. It specifically prevents cell separation in Saccharomyces cerevisiae, leading to the formation of grape-like cell clusters, without impeding cell growth. Furthermore, it blocks the morphological transition of Candida albicans from its yeast form to its hyphal form, also without inhibiting cell growth.
- Chitinase inhibitor
- Disrupts cell separation in yeast by inhibiting chitinase activity
- Prevents cell separation of Saccharomyces cerevisiae without inhibiting cell growth
- Blocks morphological transition of Candida albicans from yeast to hyphal form without inhibiting cell growth
- For research use only
Apexbio Technology LLC 5-hme-CTP 10x100ul (100 mM)
5-hme-CTP (5-hydroxymethylcytidine triphosphate) is a modified cytidine triphosphate bearing a hydroxymethyl group at the 5-position carbon This modification can enhance RNA stability and functionality During in vitro mRNA synthesis 5-hme-CTP can be incorporated into RNA molecules producing RNA containing 5-hydroxymethylcytidine Hydroxymethyl-modified RNA plays an essential role in studying RNA structure function and RNA-protein interactions Additionally 5-hme-CTP significantly improves RNA stability by reducing its intracellular degradation Thus this modified nucleotide has broad applications in gene expression research RNA-based drug development and gene therapy
Medchemexpress LLC Pediocin PA 1 TFA | 95.24% | 4624.12 | 1 MG
Pediocin PA 1 TFA | 95.24% | 4624.12 | 1 MG
Medchemexpress LLC Peptide5 TFA | 98.9% | 1509.60 | 5 MG
Peptide5 TFA is a connexin 43 mimetic peptide that has been shown to reduce animal swelling, astrogliosis, and neuronal cell death following spinal cord injury. It also acts as an anti-inflammatory agent by inhibiting the NLRP3 inflammasome.
- Connexin 43 mimetic peptide
- Reduces swelling, astrogliosis, and neuronal cell death after spinal cord injury
- Inhibits NLRP3 inflammasome
- Acts as an anti-inflammatory agent