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Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties. It has potential for treating major depressive disorder and is currently in phase II clinical development as an adjunctive therapy for this condition. Studies have shown that Rapastinel Trifluoroacetate produces an antidepressant-like effect and an anxiolytic effect in animal models, without altering locomotor activity.
NMDA receptor modulator with glycine-site partial agonist properties
Potential for treating major depressive disorder
Phase II clinical development as an adjunctive therapy
Produces antidepressant-like and anxiolytic effects in animal models
Does not alter locomotor activity
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
TL13-112 is a proteolysis targeting chimera (PROTAC) designed to selectively induce degradation of anaplastic lymphoma kinase (ALK) in cellular models. It is supplied as a solid and as a 10 mM solution in DMSO for use in preclinical degradation studies, mechanistic assays, and target validation workflows.
Selective ALK degradation in cellular assays.
High purity suitable for biological studies.
Available as solid or 10 mM DMSO solution for convenient dosing.
Recommended storage conditions for powder and solvent preparations.
Applicable to mechanistic studies and preclinical target validation.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
SPI-112 is a small-molecule, selective and competitive inhibitor of SHP2 (PTPN11) used for biochemical and cellular research. It inhibits SHP2 and related protein tyrosine phosphatases and is supplied as a solid with guidance for storage and preparation of solution stocks.
Selective and competitive inhibition of SHP2 for pathway studies.
Reported IC50 values support biochemical assay characterization.
High purity solid suitable for preparation of DMSO stocks.
Available in small milligram quantities and as a prepared solution for convenience.
Storage recommendations provided to preserve compound stability.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More