Aryl iodides
Apexbio Technology LLC 4-iodo-SAHA 1219807-87-0 250mg
4-iodo-SAHA (CAS 1219807-87-0) is a hydrophobic analog of suberoylanilide hydroxamic acid (SAHA) that functions as a histone deacetylase (HDAC) inhibitor targeting both class I and II HDACs By blocking HDAC activity 4-iodo-SAHA modulates the reversible acetylation of lysine residues on histone and non-histone proteins affecting transcriptional regulation In cellular assays 4-iodo-SAHA demonstrated antiproliferative effects with EC50 values of 1 1 M in SKBR3 breast cancer cells and 0 95 0 12 0 24 0 85 and 1 3 M in HT29 U937 JA16 HL60 and K562 tumor cell lines respectively Notably it exhibited greater potency than SAHA in inhibiting proliferation of U937 leukemia cells These properties make 4-iodo-SAHA valuable for investigating HDAC-related cellular processes and cancer models
Medchemexpress LLC 5-iodo-A-85380 dihydrochloride | 1217837-17-6 | 99.0% | 363.02 | C9H13Cl2IN2O | 100 MG
5-Iodo-A-85380 dihydrochloride is a high-affinity, selective ligand for neuronal nicotinic acetylcholine receptors, with pronounced activity at the α4β2 subtype. Supplied as the dihydrochloride salt, it is intended for receptor binding, pharmacological profiling, and preclinical research applications. Reported binding affinities are 12 pM (rat) and 14 pM (human).
- High affinity for α4β2 nAChR (Kd 12 pM rat, 14 pM human).
- Provided as a dihydrochloride salt for stability in assays.
- Purity approximately 99.0% (HPLC).
- Molecular weight 363.02 and formula C9H13Cl2IN2O.
- Intended for receptor binding and pharmacological characterization in preclinical studies.
Medchemexpress LLC 6-Chloro-7-iodo-7-deazapurine | 123148-78-7 | 99.99% | C6H3ClIN3 | 5 G
6-Chloro-7-iodo-7-deazapurine is a biochemical reagent used in life science research. It serves as a biological material or organic compound and is also utilized as a pharmaceutical intermediate.
- Biochemical reagent
- Suitable for life science related research
- Used as a pharmaceutical intermediate
Medchemexpress LLC 3,5-Dimethylisoxazole-4-boronic acid pinacol ester | 832114-00-8 | 99.1% | C11H18BNO3 | 1 G
3,5-Dimethylisoxazole-4-boronic acid pinacol ester is a drug intermediate used for the synthesis of bromodomain inhibitors. This product has been tested and complies with given specifications, though it is intended for research use only.
- Drug intermediate for synthesis of bromodomain inhibitors
- Purity of 99.1% (HPLC)
- Appears as an off-white to light yellow solid
- Chemical formula C11H18BNO3
- Molecular weight 223.08
- 1H NMR spectrum consistent with structure