Anthracenes

Medchemexpress LLC 1-Piperazinecarboxylic acid, 4-[[4-(4-chlorophenoxy)-3,5-difluorophenyl]sulfonyl]-3-[(hydroxyamino)carbonyl]-, 2-methoxyethyl ester, magnesium salt (2:1) | 1224964-36-6 | 98.25% | 548.92 | 25 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

XL-784 is a selective matrix metalloproteinases (MMP) inhibitor. It exhibits IC50s of approximately 1900, 0.81, 120, 10.8, 18, and 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, and MMP-13, respectively. It is a highly potent, low-molecular-weight inhibitor of MMPs with very limited aqueous solubility. It potently inhibits MMP-2, MMP-13, and ADAM10 [TNF-α-converting enzyme (TACE)] activity in vitro, with IC50 values in the range of 1-2 nM. It also inhibits MMP-9 (IC50 ~20 nM) and ADAM17 (IC50 ~70 nM) activity. However, it shows low potency for inhibiting MMP-1 (IC50 ~2,000 nM).

• Selective matrix metalloproteinases (MMP) inhibitor.
• Potently inhibits MMP-2, MMP-13, ADAM10, MMP-9, and ADAM17 activities.
• Used for research purposes only.
• Available in solid and solution forms.

Medchemexpress LLC 1-Piperazinecarboxylic acid, 4-[[4-(4-chlorophenoxy)-3,5-difluorophenyl]sulfonyl]-3-[(hydroxyamino)carbonyl]-, 2-methoxyethyl ester, magnesium salt (2:1) | 1224964-36-6 | 98.3% | 548.92 | 1 ML

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

XL-784 is a selective matrix metalloproteinases (MMP) inhibitor. It potently inhibits MMP-2, MMP-13, and ADAM10 [TNF-α-converting enzyme (TACE)] activity in vitro, with IC50 values in the range of 1-2 nM. It also inhibits MMP-9 and ADAM17 activity, but exhibits low potency for inhibition of MMP-1.

• Selective matrix metalloproteinases (MMP) inhibitor.
• Potently inhibits MMP-2, MMP-13, and ADAM10 in vitro.
• Inhibits MMP-9 and ADAM17 activity.
• Demonstrated effectiveness in inhibiting aortic dilatation in mice.