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Apexbio Technology LLC GDC-0879(Synonyms: AR-00341677, GDC0879, GDC 0879, G-0879, G0879), 5mg, CAS: 905281-76-7.
GDC-0879 (CAS 905281-76-7) is a selective inhibitor of B-Raf kinase targeting the Raf/MEK/ERK signaling cascade implicated in tumorigenesis It specifically inhibits B-Raf harboring the V600E mutation demonstrating IC50 values of 0 13 nM against purified mutant B-Raf and 63 nM for phosphorylated ERK in MALME-3M cells In vitro assays using V600E mutant cell lines (A375 melanoma Colo205 colorectal cancer) illustrate the compound s selectivity towards B-Raf and related C-Raf kinases In mouse xenografts expressing human BRAFV600E tumors GDC-0879 treatment results in sustained ( 90%) inhibition of ERK phosphorylation and reduced tumor progression highlighting its research value in oncology studies involving Raf pathway modulation
