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Filtered Search Results
Medchemexpress LLC Pifusertib (hydrochloride) | 2930090-28-9 | 99.9% | 460.96 | 25 MG
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Pifusertib (hydrochloride) | 2930090-28-9 | 99.9% | 460.96 | 25 MG
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Ambeed AMBEED
5000847977 5 7-DICHLORO-1 6-NAPHTH 250MG
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Medchemexpress LLC Siramesine hydrochloride | 224177-60-0 | >99.69% | C30H32ClFN2O | 25 MG
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Siramesine hydrochloride is a potent sigma-2 receptor agonist, displaying subnanomolar affinity with an IC50 of 0.12 nM. It demonstrates high selectivity for sigma-2 receptors over sigma-1 receptors, with a 140-fold difference in IC50 values (17 nM for sigma-1). This compound induces cell death by destabilizing mitochondria and has shown anti-cancer activity.
- Potent sigma-2 receptor agonist
- High selectivity for sigma-2 over sigma-1 receptors
- Triggers cell death through mitochondrial destabilization
- Exhibits anti-cancer activity
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Medchemexpress LLC Glesatinib hydrochloride | 2319837-80-2 | 98.0% | 656.17 | 1 ML
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Glesatinib hydrochloride is an orally active, potent dual inhibitor of MET and SMO. This tyrosine kinase inhibitor also antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC).
- Orally active and potent MET/SMO dual inhibitor.
- Tyrosine kinase inhibitor.
- Antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC).
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Medchemexpress LLC Amantadine hydrochloride | 665-66-7 | 98.0% | 10 G
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Amantadine hydrochloride is an orally active and potent antiviral agent effective against influenza A viruses. It inhibits various ion channels, including NMDA and M2, and also targets Coronavirus ion channels. This compound also demonstrates anti-orthopoxvirus and anticancer activities, making it suitable for research in Parkinson's disease, postoperative cognitive dysfunction (POCD), and COVID-19.
- Inhibits SARS-CoV-2 replication
- Inhibits proliferation of HepG2 and SMMC-7721 cells
- Arrests cell cycle at G0/G1 phase and induces apoptosis
- Reduces levels of cell cycle-related genes and proteins
- Reduces Bcl-2 and increases Bax protein and mRNA levels
- Inhibits surgery-induced neuroinflammation and learning and memory impairment
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Ambeed AMBEED
5000848715 3- 4-BROMOPHENYL -1-PHE 1G
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AdipoGen 4 4-Dimethyl-2 2-dipyridyl
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Chemical. CAS 1134-35-6. Formula C12H12N2. MW 184.2. Synthetic. Building block and intermediate for synthesis. Used in the synthesis of a series of o-phenanthroline-substituted rutheniumII complexes and luminescent molecules.
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AdipoGen 6-Cl-2-OCH3-9-phenoxyacridine
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Chemical. CAS 7478-26-4. Formula C20H14ClNO2. MW 335.78. Synthetic. Acridine. Halogenated heterocycle used as building block.
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AdipoGen 6-Cl-2-OCH3-9-phenoxyacridine
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Chemical. CAS 7478-26-4. Formula C20H14ClNO2. MW 335.78. Synthetic. Acridine. Halogenated heterocycle used as building block.
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Medchemexpress LLC Stachydrine hydrochloride | 4136-37-2 | MFCD00060174 | 179.64 | 1 ML
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Stachydrine hydrochloride, a major active constituent of Leonurus artemisia, is a potential therapy for cardiovascular diseases. It inhibits the NF-κB signal pathway and demonstrates anti-hypertrophic activities. Research indicates it can suppress p-IκB (ser32) protein and NF-κB (p65) protein, and inhibit MCF-7 and T47D cell proliferation.
- Inhibits NF-κB signal pathway
- Exhibits anti-hypertrophic activities
- Suppresses p-IκB (ser32) protein in cytosol
- Suppresses NF-κB (p65) protein in nucleus
- Inhibits MCF-7 and T47D cell proliferation
- Induces G1 phase cell cycle arrest in cell lines
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AdipoGen trans-2-Decenoic acid
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Chemical. CAS 334-49-6. Formula C10H18O2. MW 170.25. Synthetic. trans-2-Decenoic acid is an unsaturated short chain fatty acid that is secreted by S. mutans. It is a novel interkingdom-signaling molecule from a Gram-positive organism that inhibits hyphal formation of the dimorphic fungus C. albicans by blocking the yeast-to-hyphal morphological transition. It might play a critical role in regulating the disintegration of aerobic granules. As in other parts of the body, Streptococci and Candida coexist in the mouth and compete for the same substrate. In a mixed species environment such as the oral cavity the quantitative and qualitative nature of the bacteria modulates the biofilm formation of C. albicans. trans-2-Decenoic acid is structurally similar to undecylenic acid, the active ingredient of Desenex, a widely used antifungal agent.
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AdipoGen 2 2-Dimethylcyclopentanone
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Chemical. CAS 4541-32-6. Formula C7H12O. MW 112.17. Synthetic. Building block for synthesis.
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AdipoGen cis-2-Dodecenoic acid
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Chemical. CAS 55928-65-9. Formula C12H22O2. MW 198.3. Synthetic. Burkholderia cenocepacia produces a diffusible fatty acid signal molecule, cis-2-dodecenoic acid BDSF, that has been implicated in interspecies and interkingdom communication.
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AdipoGen 3 6-Dichlorotrimellitic acid
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Chemical. CAS 137071-78-4. Formula C9H4Cl2O6. MW 279.03. Synthetic. Key precursor used for preparation of a variety of dichlorinated fluoresceins and rhodamines such as TET and HEX. These chlorinated fluoresceins and rhodamines are widely used for labeling oligos and in DNA sequencing.
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Medchemexpress LLC Tamsulosin (hydrochloride) | 106463-17-6 | 99.8% | 1 ML
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Tamsulosin hydrochloride is an orally active antagonist of the α1-adrenergic receptor. It is used in the research of prostatic hyperplasia and has been shown to induce apoptosis and attenuate abdominal aortic aneurysm growth and inflammation in animal models.
- Exhibits intrinsic activity at human alpha1B adrenergic receptor (EC50 of 0.13 nM).
- Attenuates high glucose-induced injury in human glomerular endothelial cells.
- Influences ECM production and distribution, and cellular metabolism levels in ARPE 19 cells.
- Induces apoptosis and clusterin expression in NRP-152 cells.
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