Naphthalenes

Polycyclic aromatic hydrocarbon compounds that consist of ten carbon atoms and eight hydrogen atoms fused into two benzene rings; it is the simplest polycyclic aromatic hydrocarbon.

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4,246 – 4,260 of 5,175 results

4,246

eMolecules 312693-21-3 | 4-Methylbenzylzinc chloride, 0.50 M in THF | Synthonix | MFCD01319888 | 205.990 | C8H9ClZn | 0.000 | [Cl-].Cc1ccc(C[Zn+])cc1 | 50ml | 702445949

4-Methylbenzylzinc chloride, 0.50 M in THF | Synthonix | 312693-21-3 | MFCD01319888 | 205.990 | C8H9ClZn | 0.000 | [Cl-].Cc1ccc(C[Zn+])cc1 | 50ml | 702445949

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4,247

eMolecules 58207-97-9 | Tributyl[(1E)-2-(trimethylsilyl)ethenyl]stannane | Synthonix - Stock389.286 | C17H38SiSn | 97.000 | CCCC[Sn](CCCC)(CCCC)\C=C\[Si](C)(C)C | 500mg | 525932270

Tributyl[(1E)-2-(trimethylsilyl)ethenyl]stannane | Synthonix - Stock | 58207-97-9389.286 | C17H38SiSn | 97.000 | CCCC[Sn](CCCC)(CCCC)\C=C\[Si](C)(C)C | 500mg | 525932270

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4,248

eMolecules 1217737-76-2 | (S)-tert-Butyl 3-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate | ChemScene | MFCD09955433 | 257.330 | C13H23NO4 | 97.000 | COC(=O)C[C@@H]1CCCN(C1)C(=O)OC(C)(C)C | 100mg | 687352817

(S)-tert-Butyl 3-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate | ChemScene | 1217737-76-2 | MFCD09955433 | 257.330 | C13H23NO4 | 97.000 | COC(=O)C[C@@H]1CCCN(C1)C(=O)OC(C)(C)C | 100mg | 687352817

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4,249

Medchemexpress LLC Rolapitant hydrochloride hydrate | 914462-92-3 | 98.36% | 554.95 | 100 MG

Rolapitant hydrochloride hydrate is a potent, selective, long-acting, and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. It does not interact with CYP3A4 and shows potent anti-emetic activity in a ferret emesis model.

Potent, selective, long-acting, and orally active neurokinin 1 (NK1) receptor antagonist
Ki of 0.66 nM for human NK1 receptor
Does not interact with CYP3A4
Shows potent anti-emetic activity in a ferret emesis model
High selectivity over human NK2 and NK3 subtypes (more than 1000-fold)
Preferential affinity for human, guinea pig, gerbil, and monkey NK1 receptors over rat, mouse, and rabbit
Inhibits GR-73632 (an NK1 receptor agonist)-induced calcium efflux in a concentration-dependent and competitive manner in CHO cells expressing the human NK1 receptor.

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4,250

Medchemexpress LLC Adrenalone (hydrochloride) | 62-13-5 | 99.9% | 100 MG

Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. It is also an inhibitor of dopamine β oxidase and is chemically similar to known norepinephrine transporter (NET) ligands with an IC50 of 36.9 μM. It is a topical nasal decongestant, hemostatic, and vasoconstrictor, and a keton form of the natural substrate epinephrine. Adrenalone hydrochloride inhibits the activity of dopamine β-oxidase and substrate transport by NET.

Adrenergic agonist
Topical vasoconstrictor and hemostatic
Inhibitor of dopamine β oxidase
Chemically similar to norepinephrine transporter (NET) ligands (IC50 of 36.9 μM)
Topical nasal decongestant
Keton form of natural substrate epinephrine

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4,251

Medchemexpress LLC Cinaciguat (hydrochloride) | 646995-35-9 | 98.90% | C36H40ClNO5 | 10 MM * 1 ML

Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with an EC50 of 15 nM in platelets. It is available as a 10 mM * 1 mL solution in DMSO and is suitable for various laboratory applications including research into cardiovascular disease and related classifications.

Potent soluble guanylate cyclase (GC) activator
EC50 of 15 nM in platelets
Activates apo-sGC
Modulates vasorelaxation and blood pressure

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4,252

Medchemexpress LLC Glesatinib hydrochloride | 2319837-80-2 | 98.0% | 656.17 | 1 ML

Glesatinib hydrochloride is an orally active, potent dual inhibitor of MET and SMO. This tyrosine kinase inhibitor also antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC).

Orally active and potent MET/SMO dual inhibitor.
Tyrosine kinase inhibitor.
Antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC).

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4,253

Medchemexpress LLC Prmt5-in-1 hydrochloride | 99.51% | 455.29 | 1 ML

PRMT5 IN-1 hydrochloride, a hemiaminal, is a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 11 nM for the PRMT5/MEP50 complex. This compound can be converted to aldehydes and reacts with C449 to form covalent adducts under physiological conditions. As a hydrochloride salt, it typically offers enhanced water solubility and stability.

Potent and selective inhibitor of PRMT5.
Exhibits an IC50 of 11 nM for the PRMT5/MEP50 complex.
Inhibits cellular sDMA in Granta-519 cells with an IC50 of 0.012 μM.
Demonstrates antiproliferative activity in Granta-519 cells with an IC50 of 0.06 μM.
Hydrochloride form provides enhanced water solubility and stability.

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4,254

AdipoGen trans-Methyl-2-dodecenoic acid

Chemical. CAS 677354-24-4. Formula C13H24O2. MW 212.3. Synthetic. trans-Delta2-11-methyl-Dodecenoic acid is the conformational isomer of cis-Delta2-11-methyl-dodecenoic acid, a diffusible signal factor DSF in extracellular microbial and fungal communication systems. Both prokaryotes and eukaryotes depend on small signalling molecules for cell-cell communication. In a DSF bioassay, the minimum concentration of cis-Delta2-11-methyl-dodecenoic acid required for induction of a DSF biosensor was about 0.5 µM, which is 200-fold lower than that of trans-Delta2-11-methyl-dodecenoic acid and 20,000-fold lower than that of the corresponding saturated fatty acid 11-methyl-dodecanoic acid.

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4,255

AdipoGen 2-Chlorocyclohepta-trienone

Chemical. CAS 3839-48-3. Formula C7H5ClO. MW 140.57. Synthetic. Building block for synthesis.

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4,256

AdipoGen 6-Cl-2-OCH3-9-phenoxyacridine

Chemical. CAS 7478-26-4. Formula C20H14ClNO2. MW 335.78. Synthetic. Acridine. Halogenated heterocycle used as building block.

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4,257

AdipoGen Loxistatin acid

Chemical. CAS 76684-89-4. Formula C15H26N2O5. Molecular Weight 314.4. E-64c is a potent cell-impermeable epoxysuccinyl peptide inhibitor of calpain and other cysteine proteases, such as papain, cathepsin B, H and L. Does not inhibit the serine proteases trypsin, chymotrypsin or elastase. E-64c is an active metabolite of the protease inhibitor E-64d Prod. No. AG-CR1-3737, and a synthetic analog of E-64 Prod. No. AG-CP3-7006. Studies indicate that E-64c is a more potent inhibitor of cathepsins B and L compared to E-64. E-64c has in vitro antiviral, antiparasitic and immunomodulatory properties. It reduces the autocatalytic activity of the foot-and-mouth-disease virus FMDV leader protease, reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with SARS-CoV spike glycoprotein in a concentration-dependent manner, inhibits human rotavirus replication, and exhibits entry-blocking effects against MERS-CoV.

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4,258

Selleck Chemical LLC BI-D1870 S2843-1g

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays respectively 10- to 100-fold selectivity for RSK than MST2 GSK-3 MARK3 CK1 and Aurora B BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy

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4,259

Enzo Life Sciences Gossypol (100mg). CAS: 303-45-7

Mixture of ~65% (+)- and ~35% (-)-enantiomers. Male antifertility agent with antispermatogenic activity. Shows antitumor, antiviral and antioxidant actions. Small molecule inhibitor of Bcl-2/Bcl-XL. Induces apoptosis. Synergizes with radiation and chemotherapy in vitro. Reversible inhibitor of protein phosphatase 2B (PP2B; calcineurin). Protein kinase C (PKC) inhibitor. Inhibits activities of the mitotic kinesin Eg5 (IC50=10.8µM/L). Inhibits RBL-1, 5-lipoxygenase (IC50=0.3µM) and 12-lipoxygenase (IC50=0.7µM). Inhibits PAF and leukotriene-induced guinea pig parenchyma contractions. Novel direct-acting inhibitor of calcineurin. Alternative name: 2,2'-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]. Purity: ≥90% (HPLC). Solubility: Soluble in 100% ethanol (25mg/ml), dimethylformamide (25mg/ml), acetone or DMSO; sparingly soluble in methanol (2mg/ml); insoluble in water. Long Term Storage: -20°C.

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4,260

Medchemexpress LLC EGFR vIII Human Bi 10ug | 10ug

The EGFRvIII protein is a transmembrane glycoprotein in the protein kinase superfamily that acts as a receptor for epidermal growth factor It acts on the cell surface binds to epidermal growth factor triggers receptor dimerization and tyrosine autophosphorylation and promotes cell proliferation EGFR vIII Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived EGFR vIII protein expressed by HEK293 with C-Avi C-His labeled tag

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Naphthalenes

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Medchemexpress LLC Rolapitant hydrochloride hydrate | 914462-92-3 | 98.36% | 554.95 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Adrenalone (hydrochloride) | 62-13-5 | 99.9% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cinaciguat (hydrochloride) | 646995-35-9 | 98.90% | C36H40ClNO5 | 10 MM * 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Glesatinib hydrochloride | 2319837-80-2 | 98.0% | 656.17 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Prmt5-in-1 hydrochloride | 99.51% | 455.29 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

AdipoGen trans-Methyl-2-dodecenoic acid Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

AdipoGen 2-Chlorocyclohepta-trienone Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

AdipoGen 6-Cl-2-OCH3-9-phenoxyacridine Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

AdipoGen Loxistatin acid Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Selleck Chemical LLC BI-D1870 S2843-1g Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Enzo Life Sciences Gossypol (100mg). CAS: 303-45-7 Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC EGFR vIII Human Bi 10ug | 10ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More