Naphthalenes

Medchemexpress LLC [1,1'-Biphenyl]-3-propanoic acid, a-amino-2'-chloro-5-(phosphonomethyl)-, (aS)- | 174575-17-8 | 98.8% | 25 MG

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SDZ 220-581 is an orally active, potent, competitive NMDA receptor antagonist with a pKi value of 7.7. It has been shown to dose-dependently protect mice against maximal electroshock seizures (MES) upon oral administration, with a rapid onset and long duration of action.

• Potent, competitive NMDA receptor antagonist
• Orally active
• Demonstrated pKi value of 7.7
• Protects against maximal electroshock seizures (MES) in vivo
• Offers rapid onset of action
• Provides long duration of action
• High purity of 98.76%

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Medchemexpress LLC Procaterol (hydrochloride hemihydrate) | 81262-93-3 | 99.8% | 25 MG

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Procaterol hydrochloride hemihydrate is an orally active β2 adrenoreceptor agonist primarily used for asthma research. It demonstrates significant biological activity in both in vitro and in vivo studies, including reducing rhinovirus infection, protecting cells from oxidative stress, and inhibiting inflammatory responses. This compound also alleviates cough in animal models, making it a valuable tool for related scientific investigations.

• Orally active β2 adrenoreceptor agonist
• Utilized for asthma research
• Decreases rhinovirus infection in human tracheal cells
• Inhibits IL-1β- and TNF-α-mediated eosinophil chemotactic activity
• Protects cells from H2O2-induced oxidative stress
• Inhibits histamine-induced airflow obstruction and microvascular leakage
• Abolishes Mch-induced cough in guinea pigs

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Medchemexpress LLC Vabicaserin hydrochloride | 887258-94-8 | MFCD31706226 | 99.5% | 264.79 | 100 MG

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Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT2C) receptor-selective agonist with an EC50 of 8 nM. It acts as a potent agonist, stimulating 5-HT2C receptor-coupled calcium mobilization, and also exhibits 5-HT2A receptor antagonism and 5-HT2B antagonist or partial agonist activity.

• Highly selective for 5-HT2C receptor.
• Potent agonist for 5-HT2C receptor-coupled calcium mobilization.
• Exhibits 5-HT2A receptor antagonism and 5-HT2B antagonist/partial agonist activity.
• Suitable for research use only.
• High purity: 99.47%.
• Documentation available, including Data Sheet, COA, SDS.
• Detailed solubility protocols provided for in vitro and in vivo studies.
• Supported by multiple scientific publications.
• Associated with various compound libraries.
• Investigated in clinical trials (Phase 1 and 2).

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Apexbio Technology LLC BI 6015 93987-29-2 5mg

BI 6015 is a small-molecule antagonist targeting hepatocyte nuclear factor 4 alpha (HNF4 ) a nuclear receptor implicated in transcriptional regulation within liver intestinal and pancreatic -cells It is designed to inhibit HNF4 -mediated transcriptional activation thereby modulating gene expression related to glucose and lipid metabolism BI 6015 exerts its biological activity primarily through direct antagonism of HNF4 leading to reduced transcriptional activation and lowering endogenous HNF4 protein levels In cell-based studies BI 6015 demonstrates inhibition of insulin promoter activity and suppression of endogenous insulin expression in T6PNE cells as well as decreased HNF4 protein in MIN6 and HepG2 cells Based on these pharmacological properties BI 6015 holds research potential in the study of diabetes and hepatic metabolic regulation

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Apexbio Technology LLC BI-D1870 501437-28-1 10mg

BI-D1870 (CAS 501437-28-1) is a cell-permeable small molecule inhibitor that selectively targets the p90 ribosomal S6 kinase (RSK) family comprising RSK1 RSK2 RSK3 and RSK4 It functions as an ATP-competitive inhibitor exhibiting IC50 values of 31 nM 24 nM 18 nM and 15 nM against RSK1 RSK2 RSK3 and RSK4 respectively BI-D1870 demonstrates over 500-fold greater selectivity for RSK isoforms compared to other AGC kinases In cellular assays such as with Rat-2 cells it has been shown to induce phosphorylation of ERK1/ERK2 and subsequent CREB phosphorylation BI-D1870 is widely utilized for investigating RSK-mediated signal transduction and downstream cellular processes in biomedical research

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Aobchem Ethyl 2-(naphthalen-1-yl)benzoate | 95% | CAS 954137-87-2 | C19H16O2 | 250mg

Ethyl 2-(naphthalen-1-yl)benzoate | 95% | CAS 954137-87-2 | C19H16O2 | 250mg

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Aobchem 1-Iodo-4-methoxynaphthalene | ≥97% | CAS 2607-25-2 | C11H9IO | 250mg

1-Iodo-4-methoxynaphthalene | ≥97% | CAS 2607-25-2 | C11H9IO | 250mg

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Medchemexpress LLC Melevodopa hydrochloride | 1421-65-4 | MFCD00038958 | 99.76% | 247.68 | 100 MG

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Melevodopa hydrochloride is an effervescent Levodopa prodrug. Levodopa is an orally active metabolic precursor of neurotransmitters dopamine and has anti-allodynic effects and the potential for Parkinson's disease.

• Effervescent prodrug of Levodopa
• Orally active metabolic precursor of dopamine
• Anti-allodynic effects
• Potential for Parkinson's disease treatment

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Medchemexpress LLC Melevodopa hydrochloride | 1421-65-4 | 99.8% | 247.68 | 500 MG

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Melevodopa hydrochloride is an effervescent Levodopa prodrug. Levodopa is an orally active metabolic precursor of neurotransmitters dopamine and has anti-allodynic effects and the potential for Parkinson's disease.

• Effervescent Levodopa prodrug.
• Orally active metabolic precursor of neurotransmitters dopamine.
• Anti-allodynic effects.
• Potential for Parkinson's disease.

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