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Filtered Search Results
Apexbio Technology LLC BI-D1870 501437-28-1 10mg
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BI-D1870 (CAS 501437-28-1) is a cell-permeable small molecule inhibitor that selectively targets the p90 ribosomal S6 kinase (RSK) family comprising RSK1 RSK2 RSK3 and RSK4 It functions as an ATP-competitive inhibitor exhibiting IC50 values of 31 nM 24 nM 18 nM and 15 nM against RSK1 RSK2 RSK3 and RSK4 respectively BI-D1870 demonstrates over 500-fold greater selectivity for RSK isoforms compared to other AGC kinases In cellular assays such as with Rat-2 cells it has been shown to induce phosphorylation of ERK1/ERK2 and subsequent CREB phosphorylation BI-D1870 is widely utilized for investigating RSK-mediated signal transduction and downstream cellular processes in biomedical research
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(CCCC)c1ccnc(SC)n1 | 500mg | 525920338](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502439938.PNG-250.jpg)
eMolecules 123061-49-4 | 2-(Methylthio)-4-(tributylstannyl)pyrimidine | Synthonix - Stock | MFCD01319026 | 415.230 | C17H32N2SSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1ccnc(SC)n1 | 500mg | 525920338
2-(Methylthio)-4-(tributylstannyl)pyrimidine | Synthonix - Stock | 123061-49-4 | MFCD01319026 | 415.230 | C17H32N2SSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1ccnc(SC)n1 | 500mg | 525920338
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000427809 ANCITABINE HYDROCHL 10MM 1ML
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000702363 NAPHTHOL AS-OL 100G
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Aobchem AOBCHEM
5000861573 N-METHOXY-N-METHYL-1-NAPHTHALE
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eMolecules 569-42-6 | NAPHTHALENE-1,8-DIOL | AstaTech | MFCD00042701 | 160.172 | C10H8O2 | 95.000 | Oc1cccc2cccc(O)c12 | 1g | 233625920
NAPHTHALENE-1,8-DIOL | AstaTech | 569-42-6 | MFCD00042701 | 160.172 | C10H8O2 | 95.000 | Oc1cccc2cccc(O)c12 | 1g | 233625920
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Medchemexpress LLC Umifenovir (hydrochloride) | 131707-23-8 | 99.86% | 513.88 | 1 ML
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Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral agent effective against various enveloped and non-enveloped viruses. It is utilized as an anti-influenza virus agent and can inhibit the fusion of viruses with host cells. Additionally, it has shown to be an efficient inhibitor of SARS-CoV-2 in vitro and possesses anti-inflammatory activity.
- Potent, orally active broad-spectrum antiviral
- Activity against a number of enveloped and non-enveloped viruses
- Used as an anti-influenza virus agent
- Effectively inhibits the fusion of virus with host cells
- Efficient inhibitor of SARS-CoV-2 in vitro
- Anti-inflammatory activity
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Medchemexpress LLC BI-2865 | 2937327-93-8 | C23H27N7O2S | 25 MG
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BI-2865 is a non-covalent pan-KRAS inhibitor that binds to wild-type and various mutant KRAS proteins. It effectively inhibits the proliferation of KRAS-expressing cells, making it suitable for research into KRAS-driven cancers and related pathways.
- Non-covalent pan-KRAS inhibitor
- Binds to WT, G12C, G12D, G12V, and G13D mutant KRAS
- Inhibits proliferation of G12C, G12D, or G12V mutant KRAS expressing BaF3 cells
- High purity (99.65%)
- Molecular weight: 465.57
- Derivative with a prolinol substituent and a pyrimidine linker
- Exhibits direct ionic interaction with E62
- Forms a water-mediated hydrogen bond network with R68 and Q61
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Medchemexpress LLC 2,4(1H,3H)-Pyrimidinedione, 1-[[5-(2,4-difluoro-3-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]methyl]-3-ethyl-5-methyl- | 2894848-07-6 | 99.8% | 380.37 | 100 MG
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BI-3231 is a chemical probe that acts as a potent and selective inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). With IC50 values of 1 nM for hHSD17B13 and 13 nM for mHSD17B13, it is being researched for its potential use in nonalcoholic steatohepatitis (NASH) and other liver diseases. This product is intended for research use only.
- Potent and selective HSD17B13 inhibitor
- Researched for nonalcoholic steatohepatitis (NASH) treatment
- High metabolic stability in liver microsomes
- Considerable hepatic exposure maintained over 48 hours in vivo
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eMolecules 135-13-7 | 2-(CARBOXYMETHYLTHIO)BENZOIC ACID | AstaTech | MFCD00021761 | 212.220 | C9H8O4S | 95.000 | OC(=O)CSc1ccccc1C(O)=O | 1g | 722710283
2-(CARBOXYMETHYLTHIO)BENZOIC ACID | AstaTech | 135-13-7 | MFCD00021761 | 212.220 | C9H8O4S | 95.000 | OC(=O)CSc1ccccc1C(O)=O | 1g | 722710283
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eMolecules 82-75-7 | 8-Amino-1-naphthalenesulfonic acid | Apollo Scientific | MFCD00035730 | 223.250 | C10H9NO3S | 95.000 | Nc1cccc2cccc(c12)S(O)(=O)=O | 5g | 591806787
8-Amino-1-naphthalenesulfonic acid | Apollo Scientific | 82-75-7 | MFCD00035730 | 223.250 | C10H9NO3S | 95.000 | Nc1cccc2cccc(c12)S(O)(=O)=O | 5g | 591806787
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TARGETMOL CHEMICALS INC BI-69A11 25MG
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Also available in 1 mL, 1 mg, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt. Purity 96.97%
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Medchemexpress LLC BI-3231 | 2894848-07-6 | 99.8% | 380.37 | 50 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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BI-3231 is a potent and selective chemical probe that inhibits hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), with IC50 values of 1 nM for hHSD17B13 and 13 nM for mHSD17B13. It is being researched for its potential in treating nonalcoholic steatohepatitis (NASH) and other liver diseases.
- Potent and selective hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) inhibitor
- Demonstrates high metabolic stability in liver microsomes
- Moderate metabolic stability in hepatocytes
- Significant hepatic exposure maintained over 48 hours
- Potential for research into nonalcoholic steatohepatitis (NASH) and other liver diseases
- Powder storage: -20°C for 3 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Solubility in DMSO: 125 mg/mL (328.63 mM)
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Aobchem AOBCHEM
5000863702 4-METHOXYNAPHTHALENE-1-BORONIC
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Aobchem AOBCHEM
5000863701 4-METHOXYNAPHTHALENE-1-BORONIC
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