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Filtered Search Results
Medchemexpress LLC Bi-78d3 | 883065-90-5 | MFCD12912396 | 99.9% | 379.37 g/mol | C13H9N5O5S2 | 10 MG
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BI-78D3 is a substrate-competitive inhibitor of c-Jun N-terminal kinase (JNK) used as a research tool to probe JNK-mediated signaling. It inhibits JNK kinase activity with an IC50 of approximately 280 nM and is supplied in solid and solution formats for in vitro and cell-based studies. For research use only.
- Substrate-competitive inhibitor of JNK.
- Reported IC50 of 280 nM against JNK.
- High purity (99.85%).
- Available as solid (10 mg) and as 10 mM solution in DMSO.
- Powder storage: -20°C for long-term stability.
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Sigma Aldrich Fine Chemicals Biosciences 8-Aminonaphthalene-1,3,6-trisulfonic acid disodium salt | 5398-34-5 | MFCD00070572 | 500mg
8-Aminonaphthalene-1,3,6-trisulfonic acid disodium salt | 90% | MW: 427.34 | 5398-34-5 | MFCD00070572 | 500mg
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Medchemexpress LLC Bi-D1870 | 501437-28-1 | MFCD11223662 | 99.4% | 391.42 g·mol⁻¹ | C19H23F2N5O2 | 1 ML
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BI-D1870 is a cell-permeable, ATP-competitive inhibitor of p90 ribosomal S6 kinase (RSK) isoforms 1-4 that is used in biochemical and cell-based studies to probe RSK-dependent signaling. It preferentially targets the N-terminal kinase domain and has been reported to be brain penetrant.
- ATP-competitive inhibitor of RSK isoforms (RSK1-4)
- Potent IC50s: RSK1 31 nM; RSK2 24 nM; RSK3 18 nM; RSK4 15 nM
- Cell permeable and reported to be brain penetrant
- Acts at the N-terminal kinase domain of RSK
- Available as solid or as a 10 mM solution in DMSO (1 mL)
- Typical purity approximately 99.4%
- Suitable for biochemical and cell-based studies of RSK signaling
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Aobchem AOBCHEM
5001064056 1 3-DI NAPHTHALEN-2-YL THIOURE
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Aobchem AOBCHEM
5001064068 1 3-DI NAPHTHALEN-2-YL THIOURE
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Aobchem AOBCHEM
5001075960 1 3-DIBROMO-5- 2-PROPEN-1-YL B
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Apexbio Technology LLC BI-847325 1207293-36-4 25mg
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BI-847325 (CAS 1207293-36-4) is a dual inhibitor targeting MEK1/2 and Aurora kinases with reported IC50 values of 25 nM and 4 nM against MEK1 and MEK2 and 3 nM 25 nM and 15 nM against Aurora A B and C respectively By inhibiting these kinases BI-847325 disrupts the MAPK/ERK and cell cycle signaling pathways that regulate cell proliferation and survival In cellular assays it demonstrates nanomolar EC50 values for inhibition of pERK and pHH3 in KRAS- and BRAF-mutant cancer cell lines and potently suppresses proliferation across a wide range of tumor cell models In xenograft studies it fully blocks tumor growth in BRAF- and KRAS-mutant cancer models This compound is utilized in research on kinase-targeted cancer therapies
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Apexbio Technology LLC Adapalene 106685-40-9 100mg
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Adapalene (106685-40-9) is a small-molecule agonist targeting retinoic acid receptor subtypes RAR and RAR with lower affinity for RAR and minimal activity toward RXR It is designed to selectively modulate retinoic acid receptor-mediated gene transcription thereby regulating cellular growth differentiation and apoptosis Adapalene exerts its biological activity primarily through selective activation of RAR and RAR subtypes In experimental models adapalene exhibits agonistic activity with Ki values of 2 3 nM for RAR 9 3 nM for RAR and 22 nM for RAR Based on these pharmacological properties adapalene holds research potential in investigating retinoid signaling pathways cellular proliferation apoptosis and antitumor mechanisms particularly in colorectal cancer models
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Aobchem 2 2 2-Trifluoro-1-(naphthalen-1-yl)ethanone | ≥95% | CAS 6500-37-4 | C12H7F3O | 1g
2 2 2-Trifluoro-1-(naphthalen-1-yl)ethanone | ≥95% | CAS 6500-37-4 | C12H7F3O | 1g
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Aobchem 1-Methoxy-3-(2-propen-1-yl)benzene | ≥95% | CAS 24743-14-4 | C10H12O | 1g
1-Methoxy-3-(2-propen-1-yl)benzene | ≥95% | CAS 24743-14-4 | C10H12O | 1g
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Aobchem 4-Methoxynaphthalene-1-boronic acid | ≥97% | CAS 219834-95-4 | C11H11BO3 | 5g
4-Methoxynaphthalene-1-boronic acid | ≥97% | CAS 219834-95-4 | C11H11BO3 | 5g
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Apexbio Technology LLC Adapalene sodium salt 911110-93-5 10mM (in 1mL DMSO)
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Adapalene sodium salt (CAS 911110-93-5) is a small-molecule agonist targeting retinoic acid receptors (RARs) It is designed to selectively modulate RAR-mediated signaling thereby regulating cellular differentiation and proliferation Adapalene sodium salt exerts its biological activity primarily through specific binding and activation of nuclear RAR subtypes influencing gene transcription It demonstrates agonist activity toward RARs with EC50 values of 2 3 nM 9 3 nM and 22 nM for different RAR subtypes Additionally Adapalene sodium salt noncompetitively inhibits an unspecified enzyme s activity Based on these pharmacological properties Adapalene sodium salt holds research potential in studies of retinoid signaling cellular differentiation mechanisms dermatological disease models and antitumor investigations
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AdipoGen n-Dodecyl-beta-D-maltoside
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Chemical. CAS 69227-93-6. Formula C24H46O11. MW 510.6. Water-soluble non-ionic detergent with a hydrophilic maltose head and a hydrophobic long chain alkyl tail. It is considered a gentle detergent that is more efficient than other detergents. For functional solubilization and purification of membrane proteins. It helps to retain the native conformation and activity of membrane-associated proteins and facilitates the reforming of these proteins after denaturation. For the stabilization and activation of enzymes. The critical micelle concentration of DDM is approx. 0.18 mM in water, decreases in the presence of sodium chloride or sucrose and increases in urea.
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Aobchem AOBCHEM
5001065940 N N-BIS 1-METHYLETHYL -2-THIOP
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Aobchem AOBCHEM
5001066133 1- 3-BROMOPHENYL -2 2-DIFLUORO
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