Acrylic acids and derivatives
Medchemexpress LLC Vicriviroc maleate | 599179-03-0 | MFCD09833218 | >99.91% | 649.70 | 50 MG
Vicriviroc maleate is a potent, selective, oral bioavailable, and central nervous system (CNS) penetrated antagonist of CCR5, with a Ki of 2.5 nM. It also inhibits HIV-1 in peripheral blood mononuclear cells (PBMC).
- Potent and selective CCR5 antagonist.
- Oral bioavailable and CNS penetrated.
- Inhibits HIV-1 in PBMC cells.
- Shows mean IC50 of 0.45 nM and IC90 of 4 nM for a panel of HIV isolates.
- Exhibits weak activity against hERG (IC50, 5.8 μM).
- Inhibits chemotactic response to MIP-1α with IC50 values below 1 nM.
- Suppresses RANTES-induced signaling with a mean IC50 of 4.2 ± 1.3 nM.
- Potently suppresses tested viral isolates with geometric mean EC50s of 0.04-2.3 nM and IC90s of 0.45-18 nM.
- Demonstrates good oral availability in rats and monkeys, with no acute CNS or GI effects at 10 mg/kg dose.
Sigma Aldrich Fine Chemicals Biosciences WAY-100635 maleate salt powder | 634908-75-1 | MFCD01321056 | 5MG
WAY-100635 maleate salt powder | Mol Wt: 538.64 | 634908-75-1 | MFCD01321056 | 5MG
Medchemexpress LLC Tbopp | 1996629-79-8 | 99.6% | 490.49 g·mol⁻¹ | C24H21F3N2O4S | 5MG
TBOPP is a selective small-molecule inhibitor of DOCK1 that binds the DOCK1 DHR-2 domain and inhibits DOCK1-mediated Rac activation. It is used in preclinical research to probe DOCK1 signaling and evaluate anti-tumor effects in cell and animal studies.
- Selective DOCK1 inhibitor with IC50 8.4 μM.
- High-affinity binding to the DHR-2 domain (Kd 7.1 μM).
- Molecular formula C24H21F3N2O4S; molecular weight 490.49 g·mol⁻¹.
- High purity (99.55%).
- Soluble in DMSO (100 mg/mL) and compatible with common in vivo formulations.
- Powder stable at -20°C for extended storage.
Medchemexpress LLC HY-19749 5mg Medchemexpress, PD 151746 CAS:179461-52-0 Purity:>98%
Medchemexpress, HY-19749 5mg PD 151746 CAS:179461-52-0 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Poly(acrylic acid) (MW 10000~60000) | 9003-01-4 | ≥95.0% | 10000-60000 | 100 MG
Poly(acrylic acid) (MW 10000-60000) is a polyacrylic acid with a molecular weight of 10000-60000. It is an anionic polymer. It can be used as a corrosion-mitigating and surface-stabilizing agent.
- Anionic polymer
- Can be used as a corrosion-mitigating agent
- Can be used as a surface-stabilizing agent
Selleck Chemical LLC WAY-100635 Maleate-10mg
WAY-100635 Maleate is a potent and selective 5-HT receptor antagonist with IC50 of 0.95 nM.
Medchemexpress LLC Rosiglitazone (maleate) | 155141-29-0 | 99.73% | C22H23N3O7S | 200 MG
Rosiglitazone maleate (BRL 49653C) is a potent and selective activator of PPARγ with EC50s of 30 nM (PPARγ1), 100 nM (PPARγ2), and 60 nM (PPARγ). It also acts as a modulator of TRP channels, inhibiting TRPM2 and TRPM3, and activating TRPC5. This product is for research use only.
- Potent and selective PPARγ activator (EC50s: 30 nM for PPARγ1, 100 nM for PPARγ2, 60 nM for PPARγ).
- Modulates TRP channels, inhibiting TRPM2 (~22.5 μM) and TRPM3 (9.5 and 4.6 μM), and activating TRPC5 (~30 μM).
- Promotes adipocyte differentiation of C3H10T1/2 stem cells.
- Neuroprotective via PPARγ activation, protecting Neuro2A and hippocampal neurons from oxidative stress.
- Antidiabetic potential, reducing serum glucose, IL-6, TNF-α, and VCAM-1 levels in diabetic rats.
Medchemexpress LLC 2-propenoic acid, homopolymer | 9003-01-4 | MFCD00084394 | 3,000,000 (average) | (C3H4O2)x | 50 G
Poly(acrylic acid) (average Mw 3,000,000) is a high-molecular-weight anionic polymer supplied as a white to off-white solid for research and materials applications. It is used in formulations, coatings, and studies requiring polyelectrolytes or corrosion inhibition, and is provided in laboratory-scale pack sizes for ease of use.
- High molecular weight (average Mw 3,000,000).
- White to off-white solid powder.
- Anionic polymer useful as a corrosion inhibitor and surface stabilizer.
- Chemical formula: (C3H4O2)x; CAS number: 9003-01-4.
- Available in multiple pack sizes for lab use.
- Store at room temperature; solution storage recommended at lower temperatures.
eMolecules Ambeed 3-Bromo-4-chloropyridin-2-amine 250mg 552600702 A160126 0 000 221297-82-1 MFCD15143381 207 460 C5H4BrClN2
Ambeed 3-Bromo-4-chloropyridin-2-amine 250mg 552600702 A160126 0 000 221297-82-1 MFCD15143381 207 460 C5H4BrClN2
Medchemexpress LLC Quetiapine-d4 hemifumarate | 1217310-65-0 | 99.8% | 445.57 | C21H21D4N3O2 · 1/2C4H4O4 | 10 MG
Quetiapine-d4 hemifumarate is the deuterium-labeled form of quetiapine supplied as a hemifumarate salt for analytical and research use, primarily as an internal standard for LC-MS quantitation and method development.
- Deuterium-labeled quetiapine for use as an analytical internal standard.
- High purity suitable for quantitative analysis (99.8%).
- Supplied as the hemifumarate salt to improve stability and handling.
- Molecular weight 445.57 and CAS number 1217310-65-0 for precise identification.
- Available in small measured sizes for assay development, including 10 MG packages.
Medchemexpress LLC HY-B0107 200mg Medchemexpress, Acitretin CAS:55079-83-9 Purity:>98%
Medchemexpress, HY-B0107 200mg Acitretin CAS:55079-83-9 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-12432A 5mg Medchemexpress, Gilteritinib hemifumarate CAS:1254053-84-3 Purity:>98%
Medchemexpress, HY-12432A 5mg Gilteritinib hemifumarate CAS:1254053-84-3 Gilteritinib hemifumarate is a potent FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC (-)-Dizocilpine (maleate) | 121917-57-5 | C20H19NO4 | 100 MG
(-)-Dizocilpine maleate is a less active (-)-enantiomer of Dizocilpine. It functions as a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with a Ki of 211.7 nM and exhibits antidepressant effects.
- Less active (-)-enantiomer of Dizocilpine.
- Functions as a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with a Ki of 211.7 nM.
- Exhibits antidepressant effects.
- Significantly inhibits the uptake of norepinephrine, dopamine, and serotonin monoamine transporters in HEK cells in a dose-dependent manner.
- Induces rapid antidepressant effects in the social defeat stress model in male adult C57BL/6 mice at a dosage of 0.1 mg/kg via intraperitoneal injection.
eMolecules Ambeed / Dimethyl 3-aminopentanedioate hydrochloride / 1g / 491615496 / A127385 / / 77313-10-1 / MFCD14705045 / 211.640 / C7H14ClNO4
Ambeed / Dimethyl 3-aminopentanedioate hydrochloride / 1g / 491615496 / A127385 / / 77313-10-1 / MFCD14705045 / 211.640 / C7H14ClNO4
Selleck Chemical LLC 3-Aminopropionitrile fumarate S5340-100mg
3-Aminopropionitrile fumarate (Beta-Aminopropionitrile fumarate) is an organic compound and antirheumatic agent used in veterinary medicine