Organic sulfuric acids and derivatives
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Medchemexpress LLC NVP-CGM097 sulfate | 1313367-56-4 | 98.8% | 757.34 | 5 MG
NVP-CGM097 sulfate is a potent and selective MDM2 inhibitor, demonstrating an IC50 of 1.7±0.1 nM for hMDM2. It is more potent than Nutlin-3a and effectively reactivates the p53 pathway in MDM2-amplified tumor models, selectively inhibiting the proliferation of cells expressing wild-type p53.
- Binds to human MDM2 with high selectivity over MDM4.
- More potent than Nutlin-3a.
- Inhibits proliferation of cells expressing wild-type p53.
- Redistributes wild-type p53 into the cell nucleus.
- Reactivates p53 pathway in MDM2-amplified SJSA-1 human tumor models.
- Inhibits SJSA-1 tumor growth in rats.
- Well absorbed after oral dosing.
