Vinylogous acids
Medchemexpress LLC PQ-10 | 927691-21-2 | 99.77% | 403.43 | 5 MG
PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC50 and ED50 of 4.6 nM and 13 mg/kg, respectively. It induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia.
- Potent inhibitor of Phosphodiesterase 10A (PDE10A)
- Induces patterns of brain glucose metabolism, potentially serving as a translational biomarker
- Potential for researching psychiatric disorders like schizophrenia
- Shows region-specific increases in 2-DG uptake in the globus pallidus and the lateral habenula in mice
Medchemexpress LLC 4-chloro-1-piperidin-4-yl-N-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyrazole-3-carboxamide | 1817698-21-7 | MFCD28386213 | >98.0% | 371.8 g/mol | C17H18ClN7O | 50MG
BDP5290 is a small-molecule kinase inhibitor selective for Rho-associated kinases (ROCK) and myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK). It is used as a research reagent in biochemical and cell-based assays to probe pathways controlling myosin light chain phosphorylation, cell motility, and tumor cell invasion.
- Potent inhibition of ROCK1 (IC50 5 nM), ROCK2 (IC50 50 nM), MRCKα (IC50 10 nM), and MRCKβ (IC50 100 nM).
- High reported purity: >98.0%.
- Molecular formula C17H18ClN7O and molecular weight 371.8 g/mol.
- Suitable for in vitro and cell-based research applications investigating cytoskeletal regulation.
Sigma Aldrich Fine Chemicals Biosciences 4-Hydroxy-2,5-dimethyl-3(2H)-furanone | 3658-77-3 | MFCD00010706 | Sample
4-Hydroxy-2,5-dimethyl-3(2H)-furanone | Purity: ≥98% | Mol Wt: 128.13 | 3658-77-3 | MFCD00010706 | Sample
Sigma Aldrich Fine Chemicals Biosciences 2,5-Dimethyl-4-methoxy-3(2H)-furanone >=97%, FG | 4077-47-8 | MFCD00209504 | 1KG
2,5-Dimethyl-4-methoxy-3(2H)-furanone >=97%, FG | Purity: >=97% | Mol Wt: 142.15 | 4077-47-8 | MFCD00209504 | 1KG
Selleck Chemical LLC 4-Hydroxy-2.5-dimethyl-3(2H)furanone S5178-25mg
4-Hydroxy-2 5-dimethyl-3(2H)furanone (furaneol HDMF) is a naturally occurring substance found in a variety of fruits and has been shown to have antimicrobial activity
eMolecules 1193397-42-0 | 1-(prop-2-en-1-yl)cyclobutane-1-carboxylic acid | MFCD19229282 | 1g
ChemScene | 5-Bromo-8-fluoro-34-dihydronaphthalen-1(2H)-one | 100mg | 632326122 | CS-0162485 | 1260010-73-8 | 243.075 | C10H8BrFO
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Medchemexpress LLC Ensitrelvir fumarate | 2757470-18-9 | 100.0% | C26H21ClF3N9O6 | 50 MG
Ensitrelvir fumarate, also known as S-217622 fumarate, is the first orally active, non-covalent, and non-peptidic SARS-CoV-2 3CL protease inhibitor with an IC50 of 13 nM. It demonstrates significant antiviral activity against various SARS-CoV-2 variants, SARS-CoV, and MERS-CoV.
- First orally active, non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor
- Inhibits SARS-CoV-2 3CL protease with an IC50 of 13 nM
- Effective against wild-type SARS-CoV-2 and Alpha, Beta, Gamma, and Delta variants with EC50 values around 0.4 μM
- Shows EC50 values of 0.21 μM for SARS-CoV and 1.4 μM for MERS-CoV
- Dose-dependently inhibits intrapulmonary replication of SARS-CoV-2 in mice
Matrix Scientific 3-ETHOXYACRYLOYL CHLORIDE3-E-1
3-ethoxyacryloyl Chloride Mf C5h7clo2 Mw 134.56 Cas 6191-99-7
Medchemexpress LLC Revumenib | 2169919-21-3 | 99.99% | 630.82 | 50 MG
Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell-based IC50 of 10-20 nM. It can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).
- Potent and specific Menin-MLL inhibitor
- Applicable for research into MLL-rearranged acute leukemias (ALL and AML)
- Shows in vivo plasma IC50 of 53 nM
- Provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts in vivo
Medchemexpress LLC Sparfosic acid | 51321-79-0 | 99.3% | 255.12 g/mol | C6H10NO8P | 5 MG
Sparfosic acid is N-phosphonacetyl-L-aspartic acid, a DNA antimetabolite and potent inhibitor of aspartate transcarbamoyl transferase (ATCase). It is used in biochemical and cell-based research to disrupt de novo pyrimidine biosynthesis and has been reported to increase the cytotoxic effect of 5-fluorouracil combined with interferon-alpha in cancer cell models.
- Inhibits aspartate transcarbamoyl transferase (ATCase).
- Acts as a DNA antimetabolite affecting pyrimidine biosynthesis.
- Reported to enhance cytotoxicity of 5-fluorouracil plus interferon-alpha.
- High purity (99.3%) suitable for biochemical studies.
- Available in small research pack sizes (1 mg-100 mg).
- Molecular formula C6H10NO8P; molecular weight 255.12 g/mol.
Medchemexpress LLC Ro60-0175 fumarate | 169675-09-6 | MFCD06798313 | 99.5% | 342.75 | C15H16ClFN2O4 | 5 MG
Ro60-0175 fumarate is a research-grade small molecule agonist selective for the serotonin 5-HT2C receptor, used in pharmacology and neuroscience studies to probe 5-HT2C-mediated signaling in cellular and in vivo models.
- Selective 5-HT2C receptor agonist for pharmacology research.
- Reported purity 99.47% by HPLC.
- Molecular weight 342.75 g/mol.
- Chemical formula C15H16ClFN2O4.
- Available as solid 5 MG and as a 10 mM solution in DMSO (1 ML).
- Soluble in DMSO for solution preparation and dosing in assays.
Medchemexpress LLC IACS-8803 disodium | 2243079-36-7 | 98.8% | 736.50 g·mol⁻¹ | C20H21FN10Na2O9P2S2 | 5 MG
IACS-8803 disodium is a potent cyclic dinucleotide STING agonist provided as the disodium salt for preclinical research. It activates STING signaling to stimulate interferon responses and has demonstrated robust systemic antitumor efficacy in mouse models. The compound is a white to off-white solid with high reported purity and is supplied in small solid quantities or as a DMSO solution.
- Activates STING pathway in vitro and in vivo.
- Demonstrates robust systemic antitumor efficacy in preclinical models.
- High purity suitable for research applications.
- Soluble in DMSO and moderately soluble in water; vehicle protocols available for in vivo use.
- Store under nitrogen, away from moisture; follow cold storage recommendations.
- Available in small-mass solid quantities and as a prepared solution for convenience.
![Medchemexpress LLC Quinazoline, 6,7-dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]- | 927691-21-2 | 99.8% | 403.43 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386990-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Quinazoline, 6,7-dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]- | 927691-21-2 | 99.8% | 403.43 | 50 MG
PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC50 and ED50 values of 4.6 nM and 13 mg/kg, respectively. It induces patterns of brain glucose metabolism, which can serve as a potential translational biomarker. It has the potential for researching psychiatric disorders like schizophrenia.
- Potent inhibitor of Phosphodiesterase 10A (PDE10A)
- IC50 of 4.6 nM
- ED50 of 13 mg/kg
- Induces patterns of brain glucose metabolism
- Potential translational biomarker
- Potential for researching psychiatric disorders like schizophrenia
eMolecules 1001-26-9 | Ethyl 3-ethoxyprop-2-enoate | Combi-Blocks144.170 | C7H12O3 | 95.000 | CCOC=CC(=O)OCC | 25g | 205384295
Ethyl 3-ethoxyprop-2-enoate | Combi-Blocks | 1001-26-9144.170 | C7H12O3 | 95.000 | CCOC=CC(=O)OCC | 25g | 205384295
Sigma Aldrich Fine Chemicals Biosciences 2,5-Dimethyl-4-methoxy-3(2H)-furanone natural, >=98%, FG | 4077-47-8 | MFCD00209504 | 1KG
2,5-Dimethyl-4-methoxy-3(2H)-furanone natural, >=98%, FG | Purity: >=98% | Mol Wt: 142.15 | 4077-47-8 | MFCD00209504 | 1KG