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A monoterpene lactone with diverse biological activities scavenges DPPH and peroxide radicals in cell-free assays from 62 5-250 UM reduces peroxide-induced apoptosis in Vero cells inhibits LPS-induced proliferation of isolated mouse T and B cells at 10 Ug/ml reduces HCV infectivity in Huh7 5 cells (EC50 2 48 UM) inhibits HCV binding to Huh7 5 cells at 10 and 50 UM
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A DPP-4 inhibitor (IC50 18 nM) selective for DPP-4 over DPP-8 (IC50 48 UM) as well as several other peptidases improves glucose tolerance in insulin-resistant Zucker fatty and high-fat diet fed rats as well as ob/ob and high-fat diet fed mice reduces hyperglycemia in mice fed a high-fat diet with streptozotocin-induced diabetes
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Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 M and also inhibits the influx of 22Na into rat brain synaptosomes with IC50 about 100 M
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