Azetidines
Medchemexpress LLC NSC319726 (ZMC1) | 71555-25-4 | 99.6% | 234.32 | 100 MG
NSC319726 (ZMC1) is a mutant p53R175 reactivator. It inhibits the growth of fibroblasts expressing the p53R175 mutation with an IC50 of 8 nM, showing no inhibition for p53 wild-type cells. This compound has demonstrated significant inhibition of tumor growth in TOV112D (p53R175H) xenografts in vivo, providing evidence for allele-specific p53 mutant reactivation.
- Mutant p53R175 reactivator with IC50 of 8 nM against p53R175 mutation
- No inhibition for p53 wild-type cells
- High sensitivity for MEF-p53R172H/R172H cell line
- Inhibits tumor growth in TOV112D (p53R175H) xenografts in vivo
- Provides in vivo evidence for allele-specific p53 mutant reactivation
- CC50 < 0.02 μM for Caco-2 cell toxicity
- IC50 < 0.02 μM for Caco-2 cell SARS-CoV-2 cytotoxicity inhibition
- EC50 0.005 μM for TOV112D cell growth inhibition
Medchemexpress LLC L-azetidine-2-carboxylic acid | 2133-34-8 | 99.9% | 101.10 g/mol | C4H7NO2 | 1 ML
L-azetidine-2-carboxylic acid is a proline analog research reagent used to study protein folding, endoplasmic reticulum (ER) stress, autophagy, and apoptosis pathways. It is supplied as a solid and as a 10 mM solution in water and has reported high chemical purity.
- Proline analog that perturbs protein synthesis and folding
- Induces ER stress and protein misfolding
- Upregulates LC3-II via PERK activation (autophagy marker)
- Increases pro-apoptotic BAX and induces ATF6 cleavage
- Available as solid and as a 10 mM, 1 mL aqueous solution
- High purity, reported at 99.85%
- CAS number 2133-34-8; formula C4H7NO2; molecular weight 101.10 g/mol
Medchemexpress LLC 1-Boc-L-azetidine-2-carboxylic acid | 51077-14-6 | 201.22 | 1 G
(S)-1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid is a biochemical reagent. It can be utilized as a biological material or organic compound for life science related research.
- Can be used as a biological material
- Can be used as an organic compound
- Suitable for life science related research
Medchemexpress LLC 1-Boc-D-azetidine-2-carboxylic acid | 228857-58-7 | MFCD01320888 | >=97.0% | 201.22 g·mol⁻¹ | C9H15NO4 | 250 MG
1-Boc-D-azetidine-2-carboxylic acid is a Boc-protected D-azetidine amino acid derivative used as a chemical intermediate in medicinal chemistry and organic synthesis. It serves as a protected building block for introducing an azetidine unit into peptides and small molecules; intended for research use only.
- Boc-protected azetidine scaffold for synthetic incorporation.
- Suitable for peptide and small-molecule synthesis.
- Available in multiple pack sizes for scale flexibility.
- Typical purity ≥97% as supplied.
- Molecular formula C9H15NO4; molecular weight 201.22 g·mol⁻¹.
eMolecules 3-(4-Fluoro-phenoxy)-azetidine hydrochloride | 63843-78-7 | MFCD05664839 | 5g
J & W PharmLab, LLC | 3-(4-Fluoro-phenoxy)-azetidine hydrochloride | 5g | 249977612 | 25R0023S | 96.000 | 63843-78-7 | MFCD05664839 | 203.640 | C9H11ClFNO
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Teknova Carbenicillin Disodium Salt. 100g.
Premade antibiotic solutions are ready-to-use as a supplement for your tissue culture, bacteria media or other specific needs. Antibiotics are often used in cell culture to prevent contamination, maintain aseptic conditions, or select for cells containing genetic modifications.
Medchemexpress LLC Methyl 1-Boc-azetidi | 10g
Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
Medchemexpress LLC Selpercatinib 25mg | 2152628-33-4 | 25 MG
Selpercatinib analytical standard for research and analytical applications. It is intended as a reference standard for qualitative and quantitative assays, including HPLC, GC, and MS. CAS 2152628-33-4; molecular formula C29H31N7O3; molecular weight 525.60 g·mol^-1.
- Analytical standard suitable for HPLC, GC, and MS
- Potent, selective RET kinase inhibitor used in research
- Available in multiple pack sizes, including 25 MG
- Intended for qualitative and quantitative reference assays