Benzothiadiazoles

Organic heterocyclic compounds that consist of a benzene fused with a thiadiazole ring; thiadiazoles have a five-membered ring that contains two nitrogen atoms, one sulfur atoms, and two double bonds.

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Medchemexpress LLC FAUC 213 | 337972-47-1 | 99.9% | C18H19ClN4 | 50 MG

FAUC 213 is an orally active and highly selective dopamine D4 receptor complete antagonist with a Ki of 2.2 nM for hD4.4. It shows less activity on D2 and D3 receptors, with Kis of 3.4 μM and 5.3 μM respectively. This compound can cross the blood-brain barrier (BBB) and exhibits atypical antipsychotic characteristics.

Highly selective dopamine D4 receptor complete antagonist
Orally active
Crosses the blood-brain barrier (BBB)
Exhibits atypical antipsychotic characteristics
Inhibits p5-HT1 (Ki=1.2 μM), p5-HT2 (Ki=0.52 μM), and pα1 (Ki=0.27 μM)
Significantly reduces amphetamine-induced locomotor hyperactivity at 30 mg/kg
Restores prepulse inhibition reduction caused by apomorphine treatment at 30 mg/kg