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Aromatic organic heterocyclic compounds that consist of benzene fused with a thiazine; thiazines are six-membered rings that contain four carbon atoms, one nitrogen atom, and one sulfur atom.
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PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. It demonstrates antiangiogenic and antiviral activity in vitro.
Potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1)
Exhibits antiangiogenic activity in vitro
Exhibits antiviral activity in vitro
Inhibits HIV-1 in seminal plasma
Low toxicity toward several human cell lines, freshly activated PBMCs, primary CD4+ T lymphocytes, macrophages, dendritic cells, and lactobacilli
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