Biotin and derivatives
Medchemexpress LLC DBCO-PEG3-NHS ester | 2163772-16-3 | 98.5% | 605.64 g/mol | C32H35N3O9 | 10 MG
DBCO-PEG3-NHS ester is a PEG-spaced dibenzocyclooctyne (DBCO) reagent bearing an N-hydroxysuccinimide (NHS) ester. It is designed for copper-free click conjugation of azide-functionalized payloads to primary amines and is commonly used as a linker in bioconjugation workflows such as antibody-drug conjugate synthesis.
- Enables copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing partners.
- Contains an NHS ester reactive toward primary amines for facile conjugation.
- Peg3 spacer improves solubility and reduces steric hindrance at the conjugation site.
- Suitable for bioconjugation workflows, including linker installation for antibody-drug conjugates.
- Provided at high reported purity for reproducible conjugation performance.
Medchemexpress LLC Endo-BCN-NHS carbonate | 1426827-79-3 | MFCD19705416 | 99.5% | 291.30 g/mol | C15H17NO5 | 1 G
endo-BCN-NHS carbonate is an NHS carbonate reagent that installs a bicyclo[6.1.0]non-4-ynyl (BCN) strained alkyne onto primary amines, forming carbamate linkages. The BCN handle enables copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) for efficient bioconjugation of proteins, peptides, and polymers, and is commonly used to functionalize biomolecules for hydrogel cross-linking and cell-encapsulation studies.
- Reacts with primary amines to form stable carbamate linkages.
- Provides a strained alkyne handle for copper-free SPAAC bioconjugation.
- Enables efficient functionalization of proteins, peptides, and polymers.
- Facilitates hydrogel cross-linking and cell encapsulation applications.
- Supplied as a high-purity solid suitable for research use.
Medchemexpress LLC GSPT1 protein, human (biotinylated, Avi tag) | 92.0% | 10UG
Recombinant human GSPT1 protein is expressed in Sf9 insect cells and site-specifically biotinylated via an Avi tag. Supplied as a 0.22 μm filtered solution in 50 mM HEPES, pH 7.5, with 1 mM DTT, 200 mM NaCl, and 20% glycerol, the product is provided frozen and shipped on dry ice for storage at -80°C.
- Human-derived sequence spanning residues D2-D637; approx. 70.8 kDa.
- Site-specific Avi biotinylation for consistent streptavidin-based applications.
- High purity (92.0% by reducing SDS-PAGE) suitable for biochemical assays.
- Formulated with glycerol and reducing agent for enhanced stability.
- Available in small-scale sizes to support assay development and screening.
- Shipped on dry ice; recommended long-term storage at -80°C.
TARGETMOL CHEMICALS INC TCO-NHS ester 5MG
Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. TCO-NHS ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. Purity 99.77%
Sigma Aldrich Fine Chemicals Biosciences Biotin-maleimide >=95% (TLC), powder | 116919-18-7 | 100MG
Biotin-maleimide >=95% (TLC), powder | Purity: >=95% (TLC) | Mol Wt: 451.54 | 116919-18-7 | 100MG
Medchemexpress LLC DBCO-NHS ester 3 250mg | 1393350-27-0 | 416.43 g·mol⁻1 | C24H20N2O5 | 250 MG
DBCO-NHS ester 3 is a dibenzocyclooctyne (DBCO)-N-hydroxysuccinimide (NHS) ester reagent used to functionalize primary amines for copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) bioconjugation. It enables installation of a DBCO handle for subsequent conjugation to azide-labeled partners.
- Installs DBCO onto primary amines for SPAAC (copper-free) click chemistry.
- Suitable for antibody-drug conjugate linker installation, probe labeling, and general bioconjugation.
- High purity, typically 95.6%, provided as a solid white to off-white powder.
- Molecular weight 416.43 g·mol⁻1; formula C24H20N2O5.
- Available in laboratory-scale 250 MG pack size.
Medchemexpress LLC CXADR Mouse Biotin 100ug
CXADR protein is a key component of the epithelial apical junction complex which maintains the integrity of tight junctions and enables leukocyte migration through adhesive interactions with JAML This interaction activates - T cells and promotes tissue repair through cell signaling involving PI3 kinase and MAP kinase CXADR Protein Mouse (Biotinylated HEK293 Avi-His) is the recombinant mouse-derived CXADR protein expressed by HEK293 with C-Avi C-6 His labeled tag
Medchemexpress LLC Acetic acid, 2-(2-cyclooctyn-1-yloxy)-, 2,5-dioxo-1-pyrrolidinyl ester | 1425803-45-7 | MFCD28898688 | 95.0% | 279.29 g/mol | C14H17NO5 | 50 MG
Cyclooctyne-O-NHS ester is a cyclooctyne-containing N-hydroxysuccinimide (NHS) ester used as a cleavable ADC linker and click-chemistry reagent for bioconjugation. It undergoes azide-alkyne cycloaddition to enable antibody-drug conjugate construction, labeling, and related conjugation workflows.
- Cleavable ADC linker for antibody-drug conjugate synthesis.
- Reacts with azide groups via strain-promoted and copper-catalyzed azide-alkyne cycloaddition.
- NHS ester chemistry enables efficient conjugation to primary amines.
- Supplied as a solid in multiple pack sizes suitable for small-scale synthesis.
- Datasheet and safety data sheet available for handling and storage guidance.
Medchemexpress LLC Acetic acid, 2-(2-cyclooctyn-1-yloxy)-, 2,5-dioxo-1-pyrrolidinyl ester | 1425803-45-7 | MFCD28898688 | >95.0% | 279.29 | C14H17NO5 | 5 MG
Cyclooctyne-O-NHS ester is an NHS-activated cyclooctyne reagent used as a cleavable linker and click-chemistry reagent for in vitro bioconjugation and antibody-drug conjugate synthesis. The molecule combines a strained alkyne for azide-alkyne cycloaddition with an activated ester to enable efficient amine coupling.
- Enables azide-alkyne cycloaddition reactions for bioorthogonal conjugation.
- Activated NHS ester facilitates rapid coupling to primary amines.
- Designed for use as a cleavable linker in ADC synthesis and related conjugation workflows.
- Provided in small, laboratory-scale quantities suitable for research use.
- Accompanied by datasheet, certificate of analysis, and safety data sheet for traceability and safety.
Medchemexpress LLC N3-peg3-c2-nhs ester | 1245718-89-1 | MFCD23726613 | 99.9% | 344.32 g/mol | C13H20N4O7 | 10 G
Azide-terminated PEG3 NHS ester linker for bioconjugation and click-chemistry labeling. The reagent contains an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC). It is supplied as a high-purity NHS ester for amine conjugation and includes a three-unit PEG spacer to improve solubility and reduce steric hindrance.
- Azide functional group for click chemistry reactions.
- NHS ester for efficient conjugation to primary amines.
- Three-unit PEG spacer to enhance solubility.
- Noncleavable linker for stable conjugation.
- High purity suitable for research applications.
- Available in laboratory-scale 10 g packaging.