Biotin and derivatives
Medchemexpress LLC N-piperidine Ibrutinib hydrochloride | 2231747-18-3 | 98.1% | 50 MG
N-piperidine Ibrutinib hydrochloride is a reversible Ibrutinib derivative and a potent BTK inhibitor. It can be used as a BTK ligand in the synthesis of various PROTACs.
- Potent BTK inhibitor with IC50s of 51.0 nM for WT BTK and 30.7 nM for C481S BTK.
- Can be used as a BTK ligand in the synthesis of PROTACs.
- Enables synthesis of potent PROTAC BTK degraders.
Medchemexpress LLC Biotin-PEG3-NHS ester | 1253286-56-4 | 98.4% | 50 MG
Biotin-PEG3-NHS ester is a PEG-based PROTAC linker, specifically designed for use in the synthesis of PROTACs. Proteolysis Targeting Chimeras (PROTACs) function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This compound exhibits a high purity of 98.35%, has a molecular weight of 544.62, and the chemical formula C23H36N4O9S. It is presented as a solid, ranging in color from white to light yellow.
- Functions as a PEG-based linker for the synthesis of PROTACs.
- Enables PROTACs to exploit the intracellular ubiquitin-proteasome system for targeted protein degradation.
- Offers a high purity of 98.35%.
- Molecular weight: 544.62; formula: C23H36N4O9S; CAS No.: 1253286-56-4.
- Available as a solid, with a color ranging from white to light yellow.
Medchemexpress LLC Amine-PEG3-Biotin | 359860-27-8 | 99.8% | 418.55 | 50 MG
Amine-PEG3-Biotin is a signal amplification label that contains a biotin group and a terminal primary amine group, intended for research use only.
- Contains a biotin group and a terminal primary amine group.
- Appears as a white to off-white solid.
- Store at -20°C, protected from light. If in solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light.
- Soluble in H2O at 200 mg/mL (477.84 mM) and DMSO at 100 mg/mL (238.92 mM), with sonication required.
Medchemexpress LLC Biotin-PEG8-NHS ester | 2143968-03-8 | MFCD27977502 | 99.9% | C33H56N4O14S | 10MG
Biotin-PEG8-NHS ester is a PEG-based heterobifunctional linker that combines a biotin affinity tag with an N-hydroxysuccinimide (NHS) ester to enable efficient conjugation to primary amines. It is suitable for biotinylation of peptides, proteins, and small molecules, and for use as a linker in targeted protein degradation research and affinity capture workflows.
- Enables efficient conjugation to primary amines via NHS ester chemistry.
- Provides a biotin tag for streptavidin-based capture and detection.
- PEG8 spacer improves solubility and reduces steric hindrance.
- High purity for reproducible conjugation and downstream analysis.
- Suitable for synthesis of linkers and bioconjugates in research applications.
Medchemexpress LLC UV cleavable biotin-PEG2-azide | 1192802-98-4 | MFCD11845531 | 95.6% | C38H51N7O9S | 10MG
UV Cleavable Biotin-PEG2-Azide is a photocleavable biotinylation reagent containing a PEG2 spacer and an azide group. It enables capture of biomolecules via biotin-avidin interactions and controlled release upon UV irradiation, and is compatible with copper-catalyzed and strain-promoted azide-alkyne click chemistry.
- Photocleavable biotin enables UV-triggered release.
- Azide functional group for CuAAC and SPAAC conjugation.
- PEG2 spacer improves solubility and reduces steric hindrance.
- High purity suitable for biochemical applications.
- Available in small milligram-scale packages for research use.
Medchemexpress LLC Fp-biotin | 259270-28-5 | MFCD02094222 | 99.8% | 592.75 g/mol | C27H50FN4O5PS | 5 MG
FP-Biotin is a biotin-labeled organophosphorus activity-based probe for detecting and quantifying serine hydrolase enzymes in biochemical and proteomic assays. Supplied as a solid or as a 10 mM solution in DMSO, it enables enrichment of biotinylated peptides by avidin/streptavidin capture for downstream analysis of FAAH, ABHD6, and MAG-lipase activity.
- High purity (99.8%) suitable for analytical applications.
- Biotin tag enables efficient avidin/streptavidin-based enrichment.
- Detects and quantifies serine hydrolase activity such as FAAH, ABHD6, MAG-lipase.
- Available as solid and ready-to-use DMSO solution formats.
- Compatible with plasma and proteomic workflows for biomarker discovery.
Medchemexpress LLC DBCO-NHS ester 2 250mg | 1384870-47-6 | 250 MG
DBCO-NHS ester 2 is a dibenzocyclooctyne-derived N-hydroxysuccinimide (NHS) ester used as an amine-reactive linker for copper-free click chemistry and antibody-drug conjugate synthesis. The activated NHS ester enables rapid conjugation to primary amines, while the DBCO moiety enables strain-promoted azide-alkyne cycloaddition (SPAAC) without copper catalysts.
- Amine-reactive NHS ester for efficient amide bond formation
- Enables strain-promoted azide-alkyne cycloaddition (SPAAC) for copper-free click chemistry
- High purity (99.69%) suitable for bioconjugation applications
- Molecular weight 430.45 Da; formula C25H22N2O5
- Powder form; store at -20°C for long-term stability
- Packaged as a 250 mg solid for laboratory use