Biotin and derivatives
Medchemexpress LLC Bis-PEG25-NHS ester | 2221948-96-3 | 99.8% | 1413.55 g/mol | C62H112N2O33 | 250 MG
Bis-PEG25-NHS ester is a homobifunctional polyethylene glycol (PEG) linker bearing two N-hydroxysuccinimide (NHS) ester groups, used for amine-directed bioconjugation in PROTAC and ADC synthesis. It provides a hydrophilic spacer to improve solubility and facilitates cleavable linker chemistry.
- High purity (99.8%).
- Homobifunctional PEG linker with two NHS ester groups.
- Molecular weight 1413.55 g/mol and formula C62H112N2O33.
- Suitable for PROTAC and ADC linker chemistry and general amine-directed conjugation.
- Available in multiple pack sizes including 25 mg, 50 mg, 100 mg, 250 mg, 500 mg, and 1 g.
- Store sealed, away from moisture at -20°C; in solvent store at -80°C (up to 6 months) or -20°C (up to 1 month).
![Medchemexpress LLC N-(4-aminobutyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | 151294-96-1 | MFCD28397129 | 97.0% | 314.45 g/mol | C14H26N4O2S | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203872.png-250.jpg)
Medchemexpress LLC N-(4-aminobutyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | 151294-96-1 | MFCD28397129 | 97.0% | 314.45 g/mol | C14H26N4O2S | 50 MG
Biotin-C4-amide-C5-NH2 is a cleavable antibody-drug conjugate (ADC) linker bearing a biotin tag and a primary amine for affinity capture and conjugation during ADC synthesis and analysis. Intended for research use only.
- Cleavable ADC linker with biotin tag for affinity-based capture.
- Primary amine enables conjugation to payloads or linkers.
- High purity: 97.0% (typical).
- Molecular weight 314.45 g/mol; formula C14H26N4O2S.
- Storage: store at 4°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month).
- For research use only; not for human therapeutic use.
Medchemexpress LLC Biotin-SLC | 1864003-57-5 | ≥97.0% | 100 MG
Biotin-SLC is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other for the target protein. They function by utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl chain-based PROTAC linker
- Used for PROTAC synthesis
- Exploits the intracellular ubiquitin-proteasome system for selective protein degradation
- Molecular weight: 427.60
- Molecular formula: C₂₁H₃₇N₃O₄S
- Purity: ≥97.0%
- Appearance: Solid, white to off-white
- Storage at 4°C under nitrogen; in solvent: -80°C for 6 months or -20°C for 1 month under nitrogen
Medchemexpress LLC Mal-PEG8-NHS ester | 2055033-05-9 | 99.0% | 50 MG
Mal-PEG8-NHS ester is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. It appears as a colorless to light yellow viscous liquid, intended solely for research applications.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Appearance: viscous liquid
- Color: colorless to light yellow
- Molecular formula: C27H42N2O14
- Molecular weight: 618.63
- Solubility in DMSO: ≥ 100 mg/mL
Medchemexpress LLC Biotin-PEG8-NHS ester | 2143968-03-8 | 99.89% | C33H56N4O14S | 100 MG
Biotin-PEG8-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins by linking a ligand for an E3 ubiquitin ligase and a ligand for the target protein.
- For research use only
- Available in various quantities
- Multiple documentation types available
- White to off-white solid appearance
Sigma Aldrich Fine Chemicals Biosciences (+)-Biotin N-hydroxysuccinimide ester >=98% (HPLC), powder | 35013-72-0 | MFCD00078531 | 25MG
(+)-Biotin N-hydroxysuccinimide ester >=98% (HPLC), powder | Purity: >=98% (HPLC) | Mol Wt: 341.38 | 35013-72-0 | MFCD00078531 | 25MG
Medchemexpress LLC Azido-PEG3-O-NHS ester | 2110448-98-9 | 95% | C13H20N4O8 | 100 MG
Azido-PEG3-O-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent features an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN group-containing molecules.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Medchemexpress LLC Biotin-PEG4-OH | 1217609-84-1 | 98.0% | 25 MG
Biotin-PEG4-OH is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, with one ligand binding to an E3 ubiquitin ligase and the other to the target protein. These molecules leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. It has a molecular weight of 419.54 and an appearance of a white to off-white solid. This product is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Molecular weight: 419.54
- Appearance: white to off-white solid
- For research use only
eMolecules Hydroxy-PEG11-t-butyl ester | BroadpharmMFCD29049421 | 630.769 | C29H58O14 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 490840967
Hydroxy-PEG11-t-butyl ester | BroadpharmMFCD29049421 | 630.769 | C29H58O14 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 490840967
Medchemexpress LLC Dota-NHS-ester TFA | 95.0% | 25 MG
DOTA-NHS-ester (TFA) is a versatile linker for affibody molecules, essential in various imaging techniques such as small animal positron emission tomography (PET), single photon emission computed tomography (SPECT), and CT scanning. It is also used for labeling radiotracers or imaging probes, particularly for tumor detection research.
- Used as a linker for affibody molecules
- Applicable in small animal PET, SPECT, and CT scanning
- Labels radiotracers or imaging probes for tumor detection
- For research use only
- Supplied as a solid, white to off-white in color
- Molecular weight: 615.51
- Formula: C22H32F3N5O12
- Storage: -20°C, sealed, away from moisture
- Solubility (in vitro): DMSO at 125 mg/mL (203.08 mM), requires ultrasonic
Medchemexpress LLC BHQ-2 NHS | 916753-62-3 | 97.7% | 603.58 | 5 MG
BHQ-2 NHS is a dark quencher lacking native emission, attributed to its polyaromatic-azo backbone and a terminal NHS ester. It features a broad and intense quenching range from 560-670 nm, making it suitable for fluorescence resonance energy transfer (FRET) applications when used with orange to far-red emitting dyes. The NHS ester allows for labeling of primary amines (-NH2) on proteins, amine-modified oligonucleotides, and other amine-containing molecules.
- Dark quencher with no native emission.
- Polyaromatic-azo backbone and a terminal NHS ester.
- Wide and intense quenching range from 560-670 nm.
- Useful as an acceptor in FRET applications.
- Can label primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
- For research use only.
Medchemexpress LLC m-PEG-NHS ester (MW 10000) | 92451-01-9 | 98.0% | Poly(oxy-1,2-ethanediyl), α-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-ω-methoxy- | 1 G
m-PEG-NHS ester (MW 10000) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules feature two distinct ligands joined by a linker: one targeting an E3 ubiquitin ligase and the other binding to a specific target protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system to degrade target proteins
- Solid, white to off-white appearance
- For research use only
Medchemexpress LLC Sulfo-Cy3-NHS disodium | 865.90 g/mol | C36H41N3Na2O13S3 | 10 MG
Sulfo-Cy3-NHS disodium is a water-soluble Cyanine3 (Cy3) derivative bearing an NHS ester for amine-reactive conjugation. The sulfonate groups increase aqueous solubility, making this reagent suitable for labeling proteins, peptides, and antibodies for fluorescence detection and imaging.
- Water-soluble NHS ester for efficient labeling of primary amines.
- Improved aqueous solubility due to sulfonate groups.
- Suitable for conjugation to proteins, antibodies, and peptides.
- Enables fluorescence detection and imaging applications.
- Stable solid form for routine laboratory handling and storage per manufacturer instructions.