Cycloheptathiophenes
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Medchemexpress LLC 4-Piperidinemethanamine, 1-(3-chloro-4-fluorobenzoyl)-4-fluoro-N-[[5-methyl-6-(methylamino)-2-pyridinyl... | 208109-39-1 | 99.1% | 25 MG
F13714 fumarate is a selective 5-HT1A receptor biased agonist. It exhibits antidepressant-like properties after a single administration in the mouse model of chronic mild stress, primarily by targeting 5-HT1A autoreceptors. This product is intended for research use only and is not sold to patients.
- Normalizes depressive-like behavior in UCMS mice in the forced swim test (FST).
- Rescues cortical and hippocampal deficits in p-ERK1/2 levels.
- Decreases immobility in mice by 30.3% at 2 mg/kg and 19.5% at 4 mg/kg.
- Significantly and dose-dependently decreases rectal body temperature in mice.
- Exhibits antidepressant- and anxiolytic-like properties in naive rats.
