An Aurora kinase inhibitor inhibits Aurora A and B by 82 and 60 respectively at 1 M in cell free assays selective for Aurora A and B over a panel of 13 kinases at 1 M inhibits growth of various cancer cell lines (GI50s 0 08-1 2 M) induces DNA accumulation and cell cycle arrest at the G2/M phase as well as apoptosis in HCT116 cells increases the accumulation of doxorubicin and rhodamine 123 in MDR KBv200 and MCF-7/adr cells and increases the susceptibility of MDR KBv200 MCF-7/adr S1-M1-80 and HL60/adr cells to cisplatin and doxorubicin reduces tumor growth in an HCT116 mouse xenograft model at 100 mg/kg potentiates the antitumor effects of vincristine in a KBv200 mouse xenograft model
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Also available in 1 mL, 10 mg, 25 mg, 100 mg and bulk. Please contact Fisher for quotes. D-threitol is the D-enantiomer of threitol. It has a role as a human metabolite. It is an enantiomer of a L-threitol. Purity 98%
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More